JPWO2023098908A5 - - Google Patents
Info
- Publication number
- JPWO2023098908A5 JPWO2023098908A5 JP2024532428A JP2024532428A JPWO2023098908A5 JP WO2023098908 A5 JPWO2023098908 A5 JP WO2023098908A5 JP 2024532428 A JP2024532428 A JP 2024532428A JP 2024532428 A JP2024532428 A JP 2024532428A JP WO2023098908 A5 JPWO2023098908 A5 JP WO2023098908A5
- Authority
- JP
- Japan
- Prior art keywords
- modified
- positions
- sirna
- sense strand
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2021/135465 | 2021-12-03 | ||
| CN2021135465 | 2021-12-03 | ||
| PCT/CN2022/136350 WO2023098908A1 (en) | 2021-12-03 | 2022-12-02 | Modification patterns for small interfering rna molecules with high stability and gene silencing activities |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024543963A JP2024543963A (ja) | 2024-11-26 |
| JPWO2023098908A5 true JPWO2023098908A5 (https=) | 2025-12-09 |
| JP2024543963A5 JP2024543963A5 (https=) | 2025-12-09 |
Family
ID=86611568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024532428A Pending JP2024543963A (ja) | 2021-12-03 | 2022-12-02 | 高い安定性及び遺伝子サイレンシング活性を有する低分子干渉ｒｎａ分子のための修飾パターン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250101428A1 (https=) |
| EP (1) | EP4441221A1 (https=) |
| JP (1) | JP2024543963A (https=) |
| KR (1) | KR20240130091A (https=) |
| CN (1) | CN118401665A (https=) |
| AU (1) | AU2022400971A1 (https=) |
| IL (1) | IL313116A (https=) |
| TW (1) | TW202342747A (https=) |
| WO (1) | WO2023098908A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118001297B (zh) * | 2024-02-01 | 2025-01-28 | 中国人民解放军军事科学院军事医学研究院 | 一种治疗SARS-CoV-2及其变体感染的多功能组合物及其制备方法 |
| WO2026002138A1 (zh) * | 2024-06-27 | 2026-01-02 | 成都新泽利医药科技有限公司 | 特定修饰的双链寡核苷酸及其组合物 |
| CN118976041A (zh) * | 2024-07-23 | 2024-11-19 | 安徽医科大学 | 一种靶向抑制lncRNA Gm26917基因表达的siRNA在制备治疗脓毒症的急性肺损伤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10131904B2 (en) * | 2008-02-11 | 2018-11-20 | Rxi Pharmaceuticals Corporation | Modified RNAi polynucleotides and uses thereof |
| CN107709561B (zh) * | 2015-07-31 | 2021-04-23 | 佳康尔研究所股份有限公司 | 修饰的siRNA及含有该修饰的siRNA的药物组合物 |
| WO2018185253A1 (en) * | 2017-04-05 | 2018-10-11 | Silence Therapeutics Gmbh | Ligand modified double-stranded nucleic acids |
| JP7365052B2 (ja) * | 2017-12-01 | 2023-10-19 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| CN112423795A (zh) * | 2018-12-28 | 2021-02-26 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| JP7610268B2 (ja) * | 2019-05-22 | 2025-01-08 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
-
2022
- 2022-12-02 JP JP2024532428A patent/JP2024543963A/ja active Pending
- 2022-12-02 KR KR1020247022063A patent/KR20240130091A/ko active Pending
- 2022-12-02 CN CN202280080053.1A patent/CN118401665A/zh active Pending
- 2022-12-02 US US18/715,175 patent/US20250101428A1/en active Pending
- 2022-12-02 AU AU2022400971A patent/AU2022400971A1/en active Pending
- 2022-12-02 EP EP22900712.5A patent/EP4441221A1/en active Pending
- 2022-12-02 IL IL313116A patent/IL313116A/en unknown
- 2022-12-02 WO PCT/CN2022/136350 patent/WO2023098908A1/en not_active Ceased
- 2022-12-02 TW TW111146424A patent/TW202342747A/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009532044A5 (https=) | ||
| Herdewijn | Nucleic acids with a six‐membered ‘carbohydrate’mimic in the backbone | |
| JP2005500025A5 (https=) | ||
| JP2009532392A5 (https=) | ||
| CA2453301A1 (en) | Synthetic double-stranded oligonucleotides for specific inhibition of gene expression | |
| CN114891053A (zh) | 包含可逆修饰的寡核苷酸的组合物及其用途 | |
| JPH09510714A (ja) | オリゴヌクレオチドｎ３’→ｐ５’ホスホルアミデート：合成および化合物；ハイブリダイゼーションおよびヌクレアーゼ耐性特性 | |
| JP2023068035A5 (https=) | ||
| JPH06511492A (ja) | キラルリン結合を有するオリゴヌクレオチド | |
| US6348583B1 (en) | Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids | |
| CN121079412A (zh) | 经修饰的指导rna | |
| KR20210040060A (ko) | 포스포로트리티오에이트 뉴클레오시드간 연쇄를 포함하는 올리고뉴클레오티드 | |
| JPH10504022A (ja) | 相補的ｄｎａ及びトキシン | |
| WO1994006811A1 (en) | Siloxy oligonucleotide analogs | |
| JPWO2023098908A5 (https=) | ||
| Yang et al. | Synthesis and duplex stabilization of oligonucleotides consisting of isonucleosides | |
| JPWO2021152146A5 (https=) | ||
| JPWO2023041508A5 (https=) | ||
| JP2021513851A5 (https=) | ||
| KR20210128410A (ko) | 포스포노아세트산 갭머 올리고뉴클레오티드 | |
| Yang et al. | Synthesis and enzymatic stability of oligo-nucleotides consisting of isonucleosides | |
| JPWO2023116607A5 (https=) | ||
| WO2021002359A1 (ja) | 核酸医薬とその使用 | |
| JPWO2021072395A5 (https=) | ||
| JP2021510295A (ja) | Ｇｓｋ３ｂ発現を調節するためのオリゴヌクレオチド |