CN118401665A - 具有高稳定性和基因沉默活性的小干扰rna分子的修饰模式 - Google Patents

具有高稳定性和基因沉默活性的小干扰rna分子的修饰模式 Download PDF

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CN118401665A
CN118401665A CN202280080053.1A CN202280080053A CN118401665A CN 118401665 A CN118401665 A CN 118401665A CN 202280080053 A CN202280080053 A CN 202280080053A CN 118401665 A CN118401665 A CN 118401665A
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modified
positions
sirna
sense strand
antisense strand
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Chinese (zh)
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张翼中
杨奇凡
陈慧瑜
陈怡芬
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Zhongtian Shanghai Biotechnology Co ltd
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Zhongtian Shanghai Biotechnology Co ltd
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CN202280080053.1A 2021-12-03 2022-12-02 具有高稳定性和基因沉默活性的小干扰rna分子的修饰模式 Pending CN118401665A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/135465 2021-12-03
CN2021135465 2021-12-03
PCT/CN2022/136350 WO2023098908A1 (en) 2021-12-03 2022-12-02 Modification patterns for small interfering rna molecules with high stability and gene silencing activities

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CN118401665A true CN118401665A (zh) 2024-07-26

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CN202280080053.1A Pending CN118401665A (zh) 2021-12-03 2022-12-02 具有高稳定性和基因沉默活性的小干扰rna分子的修饰模式

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US (1) US20250101428A1 (https=)
EP (1) EP4441221A1 (https=)
JP (1) JP2024543963A (https=)
KR (1) KR20240130091A (https=)
CN (1) CN118401665A (https=)
AU (1) AU2022400971A1 (https=)
IL (1) IL313116A (https=)
TW (1) TW202342747A (https=)
WO (1) WO2023098908A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN118001297B (zh) * 2024-02-01 2025-01-28 中国人民解放军军事科学院军事医学研究院 一种治疗SARS-CoV-2及其变体感染的多功能组合物及其制备方法
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物
CN118976041A (zh) * 2024-07-23 2024-11-19 安徽医科大学 一种靶向抑制lncRNA Gm26917基因表达的siRNA在制备治疗脓毒症的急性肺损伤药物中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104975020A (zh) * 2008-02-11 2015-10-14 阿克赛医药公司 经修饰的RNAi多核苷酸及其用途
WO2017022650A1 (ja) * 2015-07-31 2017-02-09 株式会社ジーンケア研究所 修飾ｓｉＲＮＡ及びそれを含む医薬組成物
WO2018185253A1 (en) * 2017-04-05 2018-10-11 Silence Therapeutics Gmbh Ligand modified double-stranded nucleic acids
WO2019105419A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112423795A (zh) * 2018-12-28 2021-02-26 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7610268B2 (ja) * 2019-05-22 2025-01-08 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、薬物組成物及び複合体ならびに調製方法と使用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104975020A (zh) * 2008-02-11 2015-10-14 阿克赛医药公司 经修饰的RNAi多核苷酸及其用途
WO2017022650A1 (ja) * 2015-07-31 2017-02-09 株式会社ジーンケア研究所 修飾ｓｉＲＮＡ及びそれを含む医薬組成物
WO2018185253A1 (en) * 2017-04-05 2018-10-11 Silence Therapeutics Gmbh Ligand modified double-stranded nucleic acids
WO2019105419A1 (zh) * 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FOSTER, D.J.等: "Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates", MOLECULAR THERAPY, vol. 26, no. 3, 31 March 2018 (2018-03-31), pages 708 - 717 *
PAVLOVA, A.S.等: "An Influence of Modification with Phosphoryl Guanidine Combined with a 2\'-O-Methyl or 2\'-Fluoro Group on the Small-Interfering-RNA Effect", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE, vol. 22, 10 September 2021 (2021-09-10), pages 9784 *

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IL313116A (en) 2024-07-01
EP4441221A1 (en) 2024-10-09
US20250101428A1 (en) 2025-03-27
KR20240130091A (ko) 2024-08-28
AU2022400971A1 (en) 2024-06-13
TW202342747A (zh) 2023-11-01
WO2023098908A1 (en) 2023-06-08
JP2024543963A (ja) 2024-11-26

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