TW202342747A - 具有高穩定性和基因沉默活性的小干擾rna分子的修飾模式 - Google Patents

具有高穩定性和基因沉默活性的小干擾rna分子的修飾模式 Download PDF

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TW202342747A
TW202342747A TW111146424A TW111146424A TW202342747A TW 202342747 A TW202342747 A TW 202342747A TW 111146424 A TW111146424 A TW 111146424A TW 111146424 A TW111146424 A TW 111146424A TW 202342747 A TW202342747 A TW 202342747A
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modified
sirna
positions
sense strand
antisense strand
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TW111146424A
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Chinese (zh)
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張翼中
楊奇凡
陳慧瑜
陳怡芬
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大陸商中天（上海）生物科技有限公司
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Publication of TW202342747A publication Critical patent/TW202342747A/zh

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TW111146424A 2021-12-03 2022-12-02 具有高穩定性和基因沉默活性的小干擾rna分子的修飾模式 TW202342747A (zh)

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WOPCT/CN2021/135465 2021-12-03
CN2021135465 2021-12-03

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TW202342747A true TW202342747A (zh) 2023-11-01

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US (1) US20250101428A1 (https=)
EP (1) EP4441221A1 (https=)
JP (1) JP2024543963A (https=)
KR (1) KR20240130091A (https=)
CN (1) CN118401665A (https=)
AU (1) AU2022400971A1 (https=)
IL (1) IL313116A (https=)
TW (1) TW202342747A (https=)
WO (1) WO2023098908A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118001297A (zh) * 2024-02-01 2024-05-10 中国人民解放军军事科学院军事医学研究院 一种治疗SARS-CoV-2及其变体感染的多功能组合物及其制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物
CN118976041A (zh) * 2024-07-23 2024-11-19 安徽医科大学 一种靶向抑制lncRNA Gm26917基因表达的siRNA在制备治疗脓毒症的急性肺损伤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131904B2 (en) * 2008-02-11 2018-11-20 Rxi Pharmaceuticals Corporation Modified RNAi polynucleotides and uses thereof
CN107709561B (zh) * 2015-07-31 2021-04-23 佳康尔研究所股份有限公司 修饰的siRNA及含有该修饰的siRNA的药物组合物
WO2018185253A1 (en) * 2017-04-05 2018-10-11 Silence Therapeutics Gmbh Ligand modified double-stranded nucleic acids
JP7365052B2 (ja) * 2017-12-01 2023-10-19 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
CN112423795A (zh) * 2018-12-28 2021-02-26 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
JP7610268B2 (ja) * 2019-05-22 2025-01-08 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、薬物組成物及び複合体ならびに調製方法と使用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118001297A (zh) * 2024-02-01 2024-05-10 中国人民解放军军事科学院军事医学研究院 一种治疗SARS-CoV-2及其变体感染的多功能组合物及其制备方法

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IL313116A (en) 2024-07-01
EP4441221A1 (en) 2024-10-09
US20250101428A1 (en) 2025-03-27
KR20240130091A (ko) 2024-08-28
AU2022400971A1 (en) 2024-06-13
WO2023098908A1 (en) 2023-06-08
CN118401665A (zh) 2024-07-26
JP2024543963A (ja) 2024-11-26

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