JPWO2023039005A5 - - Google Patents

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Publication number
JPWO2023039005A5
JPWO2023039005A5 JP2024515376A JP2024515376A JPWO2023039005A5 JP WO2023039005 A5 JPWO2023039005 A5 JP WO2023039005A5 JP 2024515376 A JP2024515376 A JP 2024515376A JP 2024515376 A JP2024515376 A JP 2024515376A JP WO2023039005 A5 JPWO2023039005 A5 JP WO2023039005A5
Authority
JP
Japan
Prior art keywords
formula
nucleotides
nucleotide
sina
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024515376A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024533371A (ja
JP2024533371A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/042808 external-priority patent/WO2023039005A2/en
Publication of JP2024533371A publication Critical patent/JP2024533371A/ja
Publication of JPWO2023039005A5 publication Critical patent/JPWO2023039005A5/ja
Publication of JP2024533371A5 publication Critical patent/JP2024533371A5/ja
Pending legal-status Critical Current

Links

JP2024515376A 2021-09-08 2022-09-07 修飾された短い干渉核酸（ｓｉＮＡ）分子及びそれらの使用 Pending JP2024533371A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163241935P 2021-09-08 2021-09-08
US63/241,935 2021-09-08
PCT/US2022/042808 WO2023039005A2 (en) 2021-09-08 2022-09-07 Modified short interfering nucleic acid (sina) molecules and uses thereof

Publications (3)

Publication Number Publication Date
JP2024533371A JP2024533371A (ja) 2024-09-12
JPWO2023039005A5 true JPWO2023039005A5 (https=) 2025-09-16
JP2024533371A5 JP2024533371A5 (https=) 2025-09-16

Family

ID=83506451

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024515376A Pending JP2024533371A (ja) 2021-09-08 2022-09-07 修飾された短い干渉核酸（ｓｉＮＡ）分子及びそれらの使用

Country Status (9)

Country Link
US (2) US12454691B2 (https=)
EP (1) EP4399217A2 (https=)
JP (1) JP2024533371A (https=)
KR (1) KR20240099159A (https=)
CN (1) CN118201942A (https=)
AU (1) AU2022344131A1 (https=)
CA (1) CA3231695A1 (https=)
TW (1) TW202320809A (https=)
WO (1) WO2023039005A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118271378A (zh) * 2022-12-29 2024-07-02 中国科学院深圳先进技术研究院 一种糖环修饰的核苷亚磷酰胺单体及其制备方法和应用
CN119836430A (zh) * 2023-05-12 2025-04-15 北京炫景瑞医药科技有限公司 修饰的核苷类似物及其用途与含核苷酸类似物的双链寡核苷酸及其用途
WO2025029913A2 (en) * 2023-07-31 2025-02-06 Basecure Therapeutics Llc Conjugates of n-acetyl-galactosamine (galnac) and oligonucleotides and uses thereof
CN117534717A (zh) * 2024-01-09 2024-02-09 凯莱英生命科学技术(天津)有限公司 5′-(e)-乙烯基磷酸酯的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
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AU2008306455C1 (en) * 2007-10-03 2014-04-17 Quark Pharmaceuticals, Inc. Novel siRNA structures
WO2011094953A1 (en) 2010-02-08 2011-08-11 F. Hoffmann-La Roche Ag Compounds for the treatment and prevention of influenza
KR101869570B1 (ko) 2010-04-28 2018-06-20 아이오니스 파마수티컬즈, 인코포레이티드 변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
WO2011139699A2 (en) * 2010-04-28 2011-11-10 Isis Pharmaceuticals, Inc. 5' modified nucleosides and oligomeric compounds prepared therefrom
HK1224229A1 (zh) 2013-06-26 2017-08-18 Alios Biopharma, Inc. 取代的核苷，核苷酸及其类似物
IL291323B2 (en) 2016-07-15 2023-09-01 Am Chemicals Llc Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
KR102350647B1 (ko) 2016-09-02 2022-01-14 다이서나 파마수이티컬, 인크. 4'-포스페이트 유사체 및 이를 포함하는 올리고뉴클레오타이드
MX2018009853A (es) 2016-09-02 2018-11-09 Arrowhead Pharmaceuticals Inc Ligandos de direccion.
MA51583A (fr) * 2018-01-04 2020-11-11 Avidity Biosciences Inc Molécules d'acide nucléique hétéroduplex et leurs utilisations
WO2019217397A2 (en) 2018-05-07 2019-11-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for improving strand biased
PE20211783A1 (es) 2018-11-08 2021-09-08 Aligos Therapeutics Inc Polimeros oligonucleotidos que inhiben el transporte de antigenos y metodos
US11033556B2 (en) 2019-02-14 2021-06-15 Aligos Therapeutics, Inc. Bicyclic sulfonamides
CN121108187A (zh) 2019-04-03 2025-12-12 阿里戈斯治疗公司 吡咯化合物
KR102641566B1 (ko) 2019-04-17 2024-02-28 알리고스 테라퓨틱스 인코포레이티드 바이사이클릭 및 트라이사이클릭 화합물
US20240352464A1 (en) * 2023-03-07 2024-10-24 Aligos Therapeutics, Inc. Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof

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