JPWO2022150540A5 - - Google Patents
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- Publication number
- JPWO2022150540A5 JPWO2022150540A5 JP2023541507A JP2023541507A JPWO2022150540A5 JP WO2022150540 A5 JPWO2022150540 A5 JP WO2022150540A5 JP 2023541507 A JP2023541507 A JP 2023541507A JP 2023541507 A JP2023541507 A JP 2023541507A JP WO2022150540 A5 JPWO2022150540 A5 JP WO2022150540A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- seizure
- diazepam
- administration
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 32
- 206010010904 Convulsion Diseases 0.000 claims description 14
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 14
- 229960003529 diazepam Drugs 0.000 claims description 12
- 206010015037 epilepsy Diseases 0.000 claims description 3
- 206010071350 Seizure cluster Diseases 0.000 claims 9
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- 239000007921 spray Substances 0.000 claims 6
- 210000002850 nasal mucosa Anatomy 0.000 claims 5
- NLEBIOOXCVAHBD-QKMCSOCLSA-N dodecyl beta-D-maltoside Chemical compound O[C@@H]1[C@@H](O)[C@H](OCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NLEBIOOXCVAHBD-QKMCSOCLSA-N 0.000 claims 4
- 235000019441 ethanol Nutrition 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 150000001298 alcohols Chemical class 0.000 claims 3
- 230000000306 recurrent effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 235000019445 benzyl alcohol Nutrition 0.000 claims 2
- 239000003186 pharmaceutical solution Substances 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- 125000002640 tocopherol group Chemical class 0.000 claims 2
- 235000019149 tocopherols Nutrition 0.000 claims 2
- 229930003802 tocotrienol Natural products 0.000 claims 2
- 239000011731 tocotrienol Substances 0.000 claims 2
- 229940068778 tocotrienols Drugs 0.000 claims 2
- 235000019148 tocotrienols Nutrition 0.000 claims 2
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 claims 1
- 229930003427 Vitamin E Natural products 0.000 claims 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 235000019165 vitamin E Nutrition 0.000 claims 1
- 239000011709 vitamin E Substances 0.000 claims 1
- 229940046009 vitamin E Drugs 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 3
- 229940049706 benzodiazepine Drugs 0.000 description 3
- 201000009010 Frontal lobe epilepsy Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 230000002109 interictal effect Effects 0.000 description 1
- 239000007922 nasal spray Substances 0.000 description 1
- 229940097496 nasal spray Drugs 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163135291P | 2021-01-08 | 2021-01-08 | |
| US63/135,291 | 2021-01-08 | ||
| US202163276761P | 2021-11-08 | 2021-11-08 | |
| US202163276760P | 2021-11-08 | 2021-11-08 | |
| US63/276,761 | 2021-11-08 | ||
| US63/276,760 | 2021-11-08 | ||
| US202163284033P | 2021-11-30 | 2021-11-30 | |
| US63/284,033 | 2021-11-30 | ||
| PCT/US2022/011538 WO2022150540A1 (en) | 2021-01-08 | 2022-01-07 | Methods and compositions for rapid delivery of anti-seizure therapeutics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024502466A JP2024502466A (ja) | 2024-01-19 |
| JP2024502466A5 JP2024502466A5 (https=) | 2025-01-15 |
| JPWO2022150540A5 true JPWO2022150540A5 (https=) | 2025-01-15 |
Family
ID=82323232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023541507A Pending JP2024502466A (ja) | 2021-01-08 | 2022-01-07 | 抗発作治療薬の急速な送達のための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20220218598A1 (https=) |
| EP (1) | EP4274618A4 (https=) |
| JP (1) | JP2024502466A (https=) |
| KR (1) | KR20230144019A (https=) |
| AU (1) | AU2022206421A1 (https=) |
| WO (1) | WO2022150540A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117580579A (zh) * | 2021-06-10 | 2024-02-20 | 纽瑞莱斯有限公司 | 用于治疗儿科患者的癫痫发作病症的方法和组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8911751B2 (en) * | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
| CA2756690C (en) * | 2008-03-28 | 2016-08-16 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine compositions |
| EP2694076A4 (en) * | 2011-04-01 | 2014-08-27 | Cpex Pharmaceuticals Inc | Nasal formulations of benzodiazepine |
| EP4085899A1 (en) * | 2011-06-14 | 2022-11-09 | Neurelis, Inc. | Administration of benzodiazepine |
-
2022
- 2022-01-07 AU AU2022206421A patent/AU2022206421A1/en active Pending
- 2022-01-07 US US17/570,535 patent/US20220218598A1/en not_active Abandoned
- 2022-01-07 JP JP2023541507A patent/JP2024502466A/ja active Pending
- 2022-01-07 KR KR1020237026748A patent/KR20230144019A/ko active Pending
- 2022-01-07 EP EP22737150.7A patent/EP4274618A4/en active Pending
- 2022-01-07 WO PCT/US2022/011538 patent/WO2022150540A1/en not_active Ceased
-
2024
- 2024-01-05 US US18/405,628 patent/US20240299290A1/en active Pending
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