JPWO2022109363A5 - - Google Patents
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- Publication number
- JPWO2022109363A5 JPWO2022109363A5 JP2023530325A JP2023530325A JPWO2022109363A5 JP WO2022109363 A5 JPWO2022109363 A5 JP WO2022109363A5 JP 2023530325 A JP2023530325 A JP 2023530325A JP 2023530325 A JP2023530325 A JP 2023530325A JP WO2022109363 A5 JPWO2022109363 A5 JP WO2022109363A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- compound
- pharma
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 substituted Chemical class 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 7
- 208000036142 Viral infection Diseases 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 108091005804 Peptidases Proteins 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 2
- 241000711573 Coronaviridae Species 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000032376 Lung infection Diseases 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- WCYWZMWISLQXQU-FIBGUPNXSA-N trideuteriomethane Chemical group [2H][C]([2H])[2H] WCYWZMWISLQXQU-FIBGUPNXSA-N 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000003627 8 membered carbocyclic group Chemical group 0.000 claims 1
- 208000001528 Coronaviridae Infections Diseases 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000127282 Middle East respiratory syndrome-related coronavirus Species 0.000 claims 1
- 241001263478 Norovirus Species 0.000 claims 1
- 241000315672 SARS coronavirus Species 0.000 claims 1
- 208000024716 acute asthma Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063117170P | 2020-11-23 | 2020-11-23 | |
| US63/117,170 | 2020-11-23 | ||
| US202163142663P | 2021-01-28 | 2021-01-28 | |
| US63/142,663 | 2021-01-28 | ||
| US17/479,244 | 2021-09-20 | ||
| US17/479,530 | 2021-09-20 | ||
| US17/479,244 US11384090B2 (en) | 2020-11-23 | 2021-09-20 | Spiropyrrolidine derived antiviral agents |
| US17/479,530 US11352363B1 (en) | 2020-11-23 | 2021-09-20 | Spiropyrrolidine derived antiviral agents |
| PCT/US2021/060247 WO2022109363A1 (en) | 2020-11-23 | 2021-11-22 | Novel spiropyrrolidine derived antiviral agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023551174A JP2023551174A (ja) | 2023-12-07 |
| JP2023551174A5 JP2023551174A5 (https=) | 2024-11-20 |
| JPWO2022109363A5 true JPWO2022109363A5 (https=) | 2024-11-20 |
Family
ID=78725298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023530325A Pending JP2023551174A (ja) | 2020-11-23 | 2021-11-22 | 新規スピロピロリジン誘導抗ウイルス剤 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP4001279A1 (https=) |
| JP (1) | JP2023551174A (https=) |
| KR (1) | KR20230124582A (https=) |
| CN (1) | CN114524821B (https=) |
| AU (1) | AU2021381437C1 (https=) |
| CA (1) | CA3173333A1 (https=) |
| CL (1) | CL2023001476A1 (https=) |
| CO (1) | CO2023008018A2 (https=) |
| IL (1) | IL302991A (https=) |
| MX (1) | MX2023005984A (https=) |
| TW (1) | TW202237616A (https=) |
| UY (1) | UY39529A (https=) |
| WO (1) | WO2022109363A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230124583A (ko) | 2020-11-23 | 2023-08-25 | 이난타 파마슈티칼스, 인코포레이티드 | 신규한 스피로피롤리딘 유래 항바이러스제 |
| US12540141B2 (en) | 2020-11-23 | 2026-02-03 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
| US12398147B2 (en) | 2021-05-11 | 2025-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| JP2024525589A (ja) | 2021-07-09 | 2024-07-12 | アリゴス セラピューティクス インコーポレイテッド | 抗ウイルス化合物 |
| US12479854B2 (en) | 2021-07-29 | 2025-11-25 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023086350A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
| WO2023109926A1 (zh) * | 2021-12-17 | 2023-06-22 | 南京药石科技股份有限公司 | 螺环氧化吲哚类化合物及其用于制备抗病毒蛋白酶抑制剂药物的用途 |
| WO2023137007A1 (en) | 2022-01-11 | 2023-07-20 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 4,6,7-trifluoro-1h-indole-2-carboxylic acid |
| JP2025509663A (ja) * | 2022-03-18 | 2025-04-11 | エナンタ ファーマシューティカルズ インコーポレイテッド | 置換スピロオキシインドール誘導体を調製するための方法 |
| WO2023196307A1 (en) | 2022-04-05 | 2023-10-12 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| CN116621918B (zh) * | 2022-07-20 | 2023-10-31 | 深圳信立泰药业股份有限公司 | 一种螺环化合物及其制备方法与应用 |
| CN115466189B (zh) * | 2022-09-19 | 2024-08-30 | 安徽普利药业有限公司 | 一种氨基酸及其衍生物的纯化方法 |
| AU2023356620A1 (en) * | 2022-10-06 | 2025-04-24 | Enanta Pharmaceuticals, Inc. | Crystal forms of an anti-sars cov-2 agent |
| CN115894504A (zh) * | 2022-10-21 | 2023-04-04 | 深圳信立泰药业股份有限公司 | 一种冠状病毒3cl蛋白酶抑制剂及其用途 |
| US20240199647A1 (en) * | 2022-11-02 | 2024-06-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2024094152A1 (zh) * | 2022-11-03 | 2024-05-10 | 中国科学院上海药物研究所 | 一类螺环化合物、其制备方法及用途 |
| CN118852175A (zh) * | 2023-01-17 | 2024-10-29 | 深圳信立泰药业股份有限公司 | 一种螺环化合物晶型及其制备方法与应用 |
| CN119139307B (zh) * | 2023-12-29 | 2025-09-23 | 上海柯君医药科技有限公司 | 螺环类化合物在制备3CLpro蛋白酶抑制剂或药物中的用途 |
| CN119930495A (zh) * | 2025-01-22 | 2025-05-06 | 中国科学技术大学先进技术研究院 | 化合物及其制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508269A (en) | 1994-10-19 | 1996-04-16 | Pathogenesis Corporation | Aminoglycoside formulation for aerosolization |
| US6083922A (en) | 1996-04-02 | 2000-07-04 | Pathogenesis, Corp. | Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| CA2524882A1 (en) | 2003-05-06 | 2004-11-25 | Cytovia, Inc. | Protease inhibitors for coronaviruses and sars-cov and the use thereof |
| EP1623028B1 (en) | 2003-05-13 | 2008-01-02 | Universität zu Lübeck | Crystal structure of human coronavirus 229e main proteinase, and uses thereof for developing sars inhibitors |
| US20060014821A1 (en) | 2003-08-27 | 2006-01-19 | Agouron Pharmaceuticals, Inc. | Inhibitors of SARS 3C like protease |
| US7462594B2 (en) | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
| WO2005113580A1 (en) | 2004-05-21 | 2005-12-01 | Pfizer Inc. | Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| WO2006061714A2 (en) | 2004-12-09 | 2006-06-15 | Pfizer Inc. | Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| PE20080403A1 (es) * | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
| MY160077A (en) * | 2011-01-21 | 2017-02-15 | Univ Sains Malaysia | Curcumin compounds and their preparations thereof |
| AR086554A1 (es) * | 2011-05-27 | 2014-01-08 | Novartis Ag | Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina |
| CA2850003C (en) | 2011-09-27 | 2020-01-07 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
| US20140349920A1 (en) * | 2012-01-03 | 2014-11-27 | Ruey J. Yu | N-acylpeptide derivatives and their uses |
| EP2844249A4 (en) | 2012-05-02 | 2016-03-09 | Univ Kansas State | MACROCYCLIC AND PEPTIDOMIMETIC COMPOUNDS AS VIRUZIDES AGAINST 3C OR 3C LIKE PROTEASES OF PICORNIVERS, CALICIVIRES AND CORONA VIRUSES |
| WO2017035409A1 (en) * | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders |
| WO2017222935A1 (en) * | 2016-06-20 | 2017-12-28 | Kansas State University Research Foundation | Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses |
| WO2018023054A1 (en) | 2016-07-28 | 2018-02-01 | Kansas State University Research Foundation | Protease transition state inhibitor prodrugs |
| UY37381A (es) | 2016-08-30 | 2018-03-23 | Glaxosmithkline Ip No 2 Ltd | Compuestos que inhiben proteasas 3c y 3cl y métodos de uso de los mismos |
| JP7691691B2 (ja) * | 2020-09-11 | 2025-06-12 | 公立大学法人横浜市立大学 | 新型コロナウイルス感染症の予防又は治療用の食品組成物、医薬品組成物、医薬部外品組成物、化粧品組成物、及び雑貨 |
| KR20230124583A (ko) * | 2020-11-23 | 2023-08-25 | 이난타 파마슈티칼스, 인코포레이티드 | 신규한 스피로피롤리딘 유래 항바이러스제 |
-
2021
- 2021-11-22 IL IL302991A patent/IL302991A/en unknown
- 2021-11-22 JP JP2023530325A patent/JP2023551174A/ja active Pending
- 2021-11-22 KR KR1020237020684A patent/KR20230124582A/ko active Pending
- 2021-11-22 EP EP21209522.8A patent/EP4001279A1/en active Pending
- 2021-11-22 WO PCT/US2021/060247 patent/WO2022109363A1/en not_active Ceased
- 2021-11-22 CA CA3173333A patent/CA3173333A1/en active Pending
- 2021-11-22 MX MX2023005984A patent/MX2023005984A/es unknown
- 2021-11-22 UY UY0001039529A patent/UY39529A/es unknown
- 2021-11-22 CN CN202111385187.8A patent/CN114524821B/zh active Active
- 2021-11-22 AU AU2021381437A patent/AU2021381437C1/en active Active
- 2021-11-23 TW TW110143587A patent/TW202237616A/zh unknown
-
2023
- 2023-05-22 CL CL2023001476A patent/CL2023001476A1/es unknown
- 2023-06-20 CO CONC2023/0008018A patent/CO2023008018A2/es unknown
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