JPWO2022080461A1 - - Google Patents

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Publication number
JPWO2022080461A1
JPWO2022080461A1 JP2022557453A JP2022557453A JPWO2022080461A1 JP WO2022080461 A1 JPWO2022080461 A1 JP WO2022080461A1 JP 2022557453 A JP2022557453 A JP 2022557453A JP 2022557453 A JP2022557453 A JP 2022557453A JP WO2022080461 A1 JPWO2022080461 A1 JP WO2022080461A1
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022557453A
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Japanese (ja)
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Publication of JPWO2022080461A1 publication Critical patent/JPWO2022080461A1/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/33—Insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/80—Neurotransmitters; Neurohormones
    • C12N2501/825—Serotonine (5-HT); Melatonine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2022557453A 2020-10-16 2021-10-14 Pending JPWO2022080461A1 (https=)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020174347 2020-10-16
JP2021053337 2021-03-26
PCT/JP2021/038095 WO2022080461A1 (ja) 2020-10-16 2021-10-14 細胞外小胞の産生用培地、培地キット、添加剤及び細胞外小胞の産生方法

Publications (1)

Publication Number Publication Date
JPWO2022080461A1 true JPWO2022080461A1 (https=) 2022-04-21

Family

ID=81208143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022557453A Pending JPWO2022080461A1 (https=) 2020-10-16 2021-10-14

Country Status (4)

Country Link
US (1) US20230250397A1 (https=)
EP (1) EP4230724A4 (https=)
JP (1) JPWO2022080461A1 (https=)
WO (1) WO2022080461A1 (https=)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518109A (ja) * 2013-03-13 2016-06-23 ユニバーシティ・オブ・マイアミＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ 細胞培養上清および生体液からの微小胞の単離および精製のための方法
JP2018064550A (ja) * 2016-07-11 2018-04-26 ナショナル ヘルス リサーチ インスティテューツＮａｔｉｏｎａｌ Ｈｅａｌｔｈ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅｓ 幹細胞からエクソソームを生成する方法およびその使用
JP2018531979A (ja) * 2015-11-02 2018-11-01 タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルＴｉｇｅｎｉｘ Ｓ．Ａ．Ｕ． 間葉幹細胞由来のエクソソームおよびその使用
JP2019513367A (ja) * 2016-03-31 2019-05-30 サンバイオ，インコーポレイティド 幹細胞の培養及び治療のための培地、方法、細胞、及び分泌因子
JP2019518428A (ja) * 2016-04-12 2019-07-04 ユニシテ エーファウ アクチェンゲゼルシャフト 体液試料からの細胞外小胞（ｅｖ）の単離
US20190240156A1 (en) * 2018-02-06 2019-08-08 Agency For Science, Technology And Research (A*Star) Therapeutic Compositions Comprising Mesenchymal Stem Cell Particles And Related Methods
CN110317788A (zh) * 2019-04-26 2019-10-11 广州瑞臻再生医学科技有限公司 一种npc培养基、外泌体的制备方法和应用
WO2020204161A1 (ja) * 2019-04-04 2020-10-08 日産化学株式会社 細胞外小胞の分泌を促進するための組成物
WO2021145396A1 (ja) * 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 血管新生剤、及び血管新生作用を有する細胞外小胞の製造方法
WO2021145395A1 (ja) * 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 抗線維化剤、及び抗線維化作用を有する細胞外小胞の製造方法
WO2021181819A1 (ja) * 2020-03-13 2021-09-16 昭和電工マテリアルズ株式会社 細胞懸濁液の製造方法、及び、接着細胞の製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4039094B2 (ja) 2001-03-30 2008-01-30 ブラザー工業株式会社 圧電アクチュエータおよび液滴噴射装置
JP2016088689A (ja) 2014-11-05 2016-05-23 セイコーエプソン株式会社 媒体保持具、媒体装填装置、記録装置
US11766402B2 (en) * 2017-11-16 2023-09-26 Board Of Regents, The University Of Texas System Methods for production of MSC-derived exosomes

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518109A (ja) * 2013-03-13 2016-06-23 ユニバーシティ・オブ・マイアミＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ 細胞培養上清および生体液からの微小胞の単離および精製のための方法
JP2018531979A (ja) * 2015-11-02 2018-11-01 タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルＴｉｇｅｎｉｘ Ｓ．Ａ．Ｕ． 間葉幹細胞由来のエクソソームおよびその使用
JP2019513367A (ja) * 2016-03-31 2019-05-30 サンバイオ，インコーポレイティド 幹細胞の培養及び治療のための培地、方法、細胞、及び分泌因子
JP2019518428A (ja) * 2016-04-12 2019-07-04 ユニシテ エーファウ アクチェンゲゼルシャフト 体液試料からの細胞外小胞（ｅｖ）の単離
JP2018064550A (ja) * 2016-07-11 2018-04-26 ナショナル ヘルス リサーチ インスティテューツＮａｔｉｏｎａｌ Ｈｅａｌｔｈ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅｓ 幹細胞からエクソソームを生成する方法およびその使用
US20190240156A1 (en) * 2018-02-06 2019-08-08 Agency For Science, Technology And Research (A*Star) Therapeutic Compositions Comprising Mesenchymal Stem Cell Particles And Related Methods
WO2020204161A1 (ja) * 2019-04-04 2020-10-08 日産化学株式会社 細胞外小胞の分泌を促進するための組成物
CN110317788A (zh) * 2019-04-26 2019-10-11 广州瑞臻再生医学科技有限公司 一种npc培养基、外泌体的制备方法和应用
WO2021145396A1 (ja) * 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 血管新生剤、及び血管新生作用を有する細胞外小胞の製造方法
WO2021145395A1 (ja) * 2020-01-15 2021-07-22 富士フイルム和光純薬株式会社 抗線維化剤、及び抗線維化作用を有する細胞外小胞の製造方法
WO2021181819A1 (ja) * 2020-03-13 2021-09-16 昭和電工マテリアルズ株式会社 細胞懸濁液の製造方法、及び、接着細胞の製造方法

Also Published As

Publication number Publication date
WO2022080461A1 (ja) 2022-04-21
EP4230724A1 (en) 2023-08-23
US20230250397A1 (en) 2023-08-10
EP4230724A4 (en) 2024-05-22

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