JPWO2022063803A5 - - Google Patents

Info

Publication number

JPWO2022063803A5

JPWO2022063803A5 JP2023518392A JP2023518392A JPWO2022063803A5 JP WO2022063803 A5 JPWO2022063803 A5 JP WO2022063803A5 JP 2023518392 A JP2023518392 A JP 2023518392A JP 2023518392 A JP2023518392 A JP 2023518392A JP WO2022063803 A5 JPWO2022063803 A5 JP WO2022063803A5

Authority

JP

Japan

Prior art keywords

seq

cell

bispecific antibody

variable region

chain variable

Prior art date

2024-09-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000427 antigen Substances 0.000 claims 27
• 102000036639 antigens Human genes 0.000 claims 27
• 108091007433 antigens Proteins 0.000 claims 27
• 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims 18
• 125000003275 alpha amino acid group Chemical group 0.000 claims 17
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 16
• 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 102000004127 Cytokines Human genes 0.000 claims 13
• 108090000695 Cytokines Proteins 0.000 claims 13
• 239000003814 drug Substances 0.000 claims 13
• 230000000694 effects Effects 0.000 claims 13
• 210000004027 cell Anatomy 0.000 claims 12
• 230000002411 adverse Effects 0.000 claims 9
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• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 5
• 108010002350 Interleukin-2 Proteins 0.000 claims 5
• 108090001005 Interleukin-6 Proteins 0.000 claims 5
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 5
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 5
• 102100037850 Interferon gamma Human genes 0.000 claims 4
• 108010074328 Interferon-gamma Proteins 0.000 claims 4
• 102000000588 Interleukin-2 Human genes 0.000 claims 4
• 102000004889 Interleukin-6 Human genes 0.000 claims 4
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• 102000012406 Carcinoembryonic Antigen Human genes 0.000 claims 3
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 3
• 108091008874 T cell receptors Proteins 0.000 claims 3
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
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• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
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• 230000019079 negative regulation of cytokine secretion Effects 0.000 claims 2
• 230000028327 secretion Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 1
• 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
• 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
• 208000001953 Hypotension Diseases 0.000 claims 1
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• -1 IFN- γ Proteins 0.000 claims 1
• 239000002067 L01XE06 - Dasatinib Substances 0.000 claims 1
• 102000036243 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Human genes 0.000 claims 1
• 108010002481 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Proteins 0.000 claims 1
• 206010037660 Pyrexia Diseases 0.000 claims 1
• 230000006044 T cell activation Effects 0.000 claims 1
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• 229960002448 dasatinib Drugs 0.000 claims 1
• 230000036543 hypotension Effects 0.000 claims 1
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• 210000002865 immune cell Anatomy 0.000 claims 1
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• 229940043355 kinase inhibitor Drugs 0.000 claims 1
• 206010025135 lupus erythematosus Diseases 0.000 claims 1
• 230000000116 mitigating effect Effects 0.000 claims 1
• 230000009437 off-target effect Effects 0.000 claims 1
• 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000002441 reversible effect Effects 0.000 claims 1
• 102000009076 src-Family Kinases Human genes 0.000 claims 1
• 108010087686 src-Family Kinases Proteins 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1