JPWO2022060487A5 - - Google Patents
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- JPWO2022060487A5 JPWO2022060487A5 JP2023517699A JP2023517699A JPWO2022060487A5 JP WO2022060487 A5 JPWO2022060487 A5 JP WO2022060487A5 JP 2023517699 A JP2023517699 A JP 2023517699A JP 2023517699 A JP2023517699 A JP 2023517699A JP WO2022060487 A5 JPWO2022060487 A5 JP WO2022060487A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- composition
- immunotherapy
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims description 56
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 53
- 238000009169 immunotherapy Methods 0.000 claims description 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 28
- 239000002671 adjuvant Substances 0.000 claims description 25
- 229920001184 polypeptide Polymers 0.000 claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 claims description 21
- 230000001024 immunotherapeutic effect Effects 0.000 claims description 20
- 150000007523 nucleic acids Chemical class 0.000 claims description 20
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 102000003802 alpha-Synuclein Human genes 0.000 claims description 17
- 108090000185 alpha-Synuclein Proteins 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 13
- 208000001089 Multiple system atrophy Diseases 0.000 claims description 12
- 210000004899 c-terminal region Anatomy 0.000 claims description 12
- 230000028993 immune response Effects 0.000 claims description 9
- 208000032859 Synucleinopathies Diseases 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 8
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 8
- 239000002105 nanoparticle Substances 0.000 claims description 8
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims description 7
- 208000024827 Alzheimer disease Diseases 0.000 claims description 6
- 208000018737 Parkinson disease Diseases 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- VWEWCZSUWOEEFM-WDSKDSINSA-N Ala-Gly-Ala-Gly Chemical compound C[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(O)=O VWEWCZSUWOEEFM-WDSKDSINSA-N 0.000 claims description 5
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 5
- 230000001939 inductive effect Effects 0.000 claims description 5
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 claims description 4
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 claims description 4
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims description 4
- 241001123946 Gaga Species 0.000 claims description 4
- 201000002832 Lewy body dementia Diseases 0.000 claims description 4
- 235000001014 amino acid Nutrition 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 239000010931 gold Substances 0.000 claims description 4
- 229910052737 gold Inorganic materials 0.000 claims description 4
- 210000002443 helper t lymphocyte Anatomy 0.000 claims description 4
- 230000003308 immunostimulating effect Effects 0.000 claims description 4
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 4
- 201000007601 neurodegeneration with brain iron accumulation Diseases 0.000 claims description 4
- 238000006116 polymerization reaction Methods 0.000 claims description 4
- 229960000814 tetanus toxoid Drugs 0.000 claims description 4
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 3
- 230000002776 aggregation Effects 0.000 claims description 3
- 238000004220 aggregation Methods 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims description 2
- 206010012289 Dementia Diseases 0.000 claims description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims description 2
- 108010040721 Flagellin Proteins 0.000 claims description 2
- 241000606768 Haemophilus influenzae Species 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 101710116435 Outer membrane protein Proteins 0.000 claims description 2
- 108010058846 Ovalbumin Proteins 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 2
- 108010039918 Polylysine Proteins 0.000 claims description 2
- 101710188053 Protein D Proteins 0.000 claims description 2
- 101900161471 Pseudomonas aeruginosa Exotoxin A Proteins 0.000 claims description 2
- 101710132893 Resolvase Proteins 0.000 claims description 2
- 108010071390 Serum Albumin Proteins 0.000 claims description 2
- 102000007562 Serum Albumin Human genes 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 102000009843 Thyroglobulin Human genes 0.000 claims description 2
- 108010034949 Thyroglobulin Proteins 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 2
- 150000001412 amines Chemical group 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 210000004558 lewy body Anatomy 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 229940092253 ovalbumin Drugs 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 229920002643 polyglutamic acid Polymers 0.000 claims description 2
- 229920000656 polylysine Polymers 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 229960002175 thyroglobulin Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 125000003275 alpha amino acid group Chemical group 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 2
- 230000003982 neuronal uptake Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063079819P | 2020-09-17 | 2020-09-17 | |
| US63/079,819 | 2020-09-17 | ||
| PCT/US2021/045055 WO2022060487A1 (en) | 2020-09-17 | 2021-08-06 | Alpha-synuclein vaccine for the treatment of synucleinopathies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023541671A JP2023541671A (ja) | 2023-10-03 |
| JPWO2022060487A5 true JPWO2022060487A5 (https=) | 2024-08-14 |
| JP2023541671A5 JP2023541671A5 (https=) | 2024-08-14 |
Family
ID=80777122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023517699A Pending JP2023541671A (ja) | 2020-09-17 | 2021-08-06 | シヌクレイノパチーの処置のためのアルファ－シヌクレインワクチン |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230355756A1 (https=) |
| EP (1) | EP4213867A4 (https=) |
| JP (1) | JP2023541671A (https=) |
| KR (1) | KR20230087487A (https=) |
| CN (1) | CN116783211A (https=) |
| AR (1) | AR123189A1 (https=) |
| AU (1) | AU2021344230A1 (https=) |
| CA (1) | CA3192429A1 (https=) |
| IL (1) | IL301224A (https=) |
| MX (1) | MX2023003007A (https=) |
| TW (1) | TW202227465A (https=) |
| WO (1) | WO2022060487A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025507875A (ja) | 2022-02-28 | 2025-03-21 | トライデム バイオサイエンス ゲーエムベーハー ウント コンパニー カーゲー | 少なくともβ－グルカン若しくはマンナンからなるか、又はこれを含む結合体 |
| WO2023161528A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE COMPRISING AT LEAST A ß-GLUCAN |
| KR20260021636A (ko) | 2023-06-15 | 2026-02-13 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 프라이머 조성물, 접착 시스템, 및 관련 공정 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2657953A1 (en) * | 2005-07-19 | 2007-01-25 | University Of Rochester | Alpha-synuclein antibodies and methods related thereto |
| PL2118300T3 (pl) * | 2007-02-23 | 2015-11-30 | Prothena Biosciences Ltd | Zapobieganie i leczenie synukleinopatii i amyloidozy |
| US8147833B2 (en) * | 2007-02-23 | 2012-04-03 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| HUE025225T2 (en) * | 2007-02-23 | 2016-02-29 | Prothena Biosciences Ltd | Prevention and treatment of synucleinopathic and amyloidogenic diseases |
| AU2008293504B2 (en) * | 2007-08-27 | 2012-04-12 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods |
| CA2885924C (en) * | 2012-08-21 | 2022-12-13 | Institute For Molecular Medicine, Inc. | Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein |
| AU2013344571A1 (en) * | 2012-11-16 | 2015-06-04 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Gonorrheal MtrE peptides and vaccines |
| CN110506057B (zh) * | 2017-02-17 | 2023-09-29 | 百时美施贵宝公司 | Alpha突触核蛋白抗体及其应用 |
| BR112019026707A2 (pt) * | 2017-06-16 | 2020-06-30 | United Neuroscience | imunógenos de peptídeo da extremidade c-terminal da proteína alfa-sinucleína e formulações dos mesmos para o tratamento de sinucleinopatias |
| WO2019070480A1 (en) * | 2017-10-02 | 2019-04-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | ASSAY FOR DETECTION OF ALPHA-SYNUCLEIN SELF-ACTIVATION ACTIVITY ASSOCIATED WITH SYNUCLEINOPATHIES |
| KR102710762B1 (ko) * | 2017-10-25 | 2024-09-25 | 얀센 파마슈티칼즈, 인코포레이티드 | 인산화 타우 펩티드의 조성물 및 이의 용도 |
| CN112368386A (zh) * | 2018-05-23 | 2021-02-12 | 磨石肿瘤生物技术公司 | 共有抗原 |
-
2021
- 2021-08-06 JP JP2023517699A patent/JP2023541671A/ja active Pending
- 2021-08-06 KR KR1020237012532A patent/KR20230087487A/ko active Pending
- 2021-08-06 WO PCT/US2021/045055 patent/WO2022060487A1/en not_active Ceased
- 2021-08-06 MX MX2023003007A patent/MX2023003007A/es unknown
- 2021-08-06 EP EP21869943.7A patent/EP4213867A4/en active Pending
- 2021-08-06 IL IL301224A patent/IL301224A/en unknown
- 2021-08-06 CA CA3192429A patent/CA3192429A1/en active Pending
- 2021-08-06 US US18/245,533 patent/US20230355756A1/en active Pending
- 2021-08-06 CN CN202180064031.1A patent/CN116783211A/zh active Pending
- 2021-08-06 AU AU2021344230A patent/AU2021344230A1/en active Pending
- 2021-08-09 AR ARP210102220A patent/AR123189A1/es unknown
- 2021-08-09 TW TW110129346A patent/TW202227465A/zh unknown
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