JPWO2021236809A5 - - Google Patents
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- Publication number
- JPWO2021236809A5 JPWO2021236809A5 JP2022571167A JP2022571167A JPWO2021236809A5 JP WO2021236809 A5 JPWO2021236809 A5 JP WO2021236809A5 JP 2022571167 A JP2022571167 A JP 2022571167A JP 2022571167 A JP2022571167 A JP 2022571167A JP WO2021236809 A5 JPWO2021236809 A5 JP WO2021236809A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- peptide
- amino acid
- adjuvant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063027150P | 2020-05-19 | 2020-05-19 | |
| US63/027,150 | 2020-05-19 | ||
| US202063062903P | 2020-08-07 | 2020-08-07 | |
| US63/062,903 | 2020-08-07 | ||
| US202163140917P | 2021-01-24 | 2021-01-24 | |
| US63/140,917 | 2021-01-24 | ||
| PCT/US2021/033222 WO2021236809A2 (en) | 2020-05-19 | 2021-05-19 | Multi-epitope vaccine for the treatment of alzheimer's disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023526500A JP2023526500A (ja) | 2023-06-21 |
| JP2023526500A5 JP2023526500A5 (https=) | 2024-05-28 |
| JPWO2021236809A5 true JPWO2021236809A5 (https=) | 2024-05-28 |
Family
ID=78708070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022571167A Pending JP2023526500A (ja) | 2020-05-19 | 2021-05-19 | アルツハイマー病の処置のためのマルチエピトープワクチン |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US20230183304A1 (https=) |
| EP (1) | EP4153210A4 (https=) |
| JP (1) | JP2023526500A (https=) |
| KR (1) | KR20230037501A (https=) |
| CN (1) | CN115867304A (https=) |
| AU (1) | AU2021276401A1 (https=) |
| BR (1) | BR112022023366A2 (https=) |
| CA (1) | CA3178760A1 (https=) |
| CL (2) | CL2022003253A1 (https=) |
| IL (1) | IL298215A (https=) |
| JO (1) | JOP20220316A1 (https=) |
| MX (1) | MX2022014453A (https=) |
| PH (1) | PH12022553234A1 (https=) |
| TW (1) | TW202208409A (https=) |
| WO (1) | WO2021236809A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1952110T3 (en) | 2005-11-08 | 2015-08-10 | Temptime Corp | Combined frost indicators |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| CN116724046A (zh) * | 2020-09-17 | 2023-09-08 | 欧萨尔普罗席纳有限公司 | 用于治疗阿尔茨海默病之β淀粉样蛋白疫苗 |
| IL301262A (en) * | 2020-09-18 | 2023-05-01 | Othair Prothena Ltd | Multiepitope vaccine for the treatment of alzheimer's disease |
| CN116554342A (zh) * | 2022-01-29 | 2023-08-08 | 元本(珠海横琴)生物科技有限公司 | 一种融合表达Tau-4R蛋白的大肠杆菌工程菌株 |
| JP2025507875A (ja) | 2022-02-28 | 2025-03-21 | トライデム バイオサイエンス ゲーエムベーハー ウント コンパニー カーゲー | 少なくともβ-グルカン若しくはマンナンからなるか、又はこれを含む結合体 |
| WO2023161528A1 (en) | 2022-02-28 | 2023-08-31 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE COMPRISING AT LEAST A ß-GLUCAN |
| CU20230023A7 (es) | 2023-05-12 | 2024-12-09 | Ct Ingenieria Genetica Biotecnologia | Antígeno quimérico multiblanco para la inmunoterapia de la enfermedad de alzheimer |
| CN120919292A (zh) * | 2025-08-04 | 2025-11-11 | 首都医科大学宣武医院 | 用于预防或治疗阿尔茨海默病的Aβ-Tau多表位疫苗及其用途 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208036A (en) | 1985-01-07 | 1993-05-04 | Syntex (U.S.A.) Inc. | N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| WO1994012629A1 (en) | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| AU698962B2 (en) | 1993-09-14 | 1998-11-12 | Epimmune, Inc. | Alteration of immune response using pan DR-binding peptides |
| US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
| US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| US5840838A (en) | 1996-02-29 | 1998-11-24 | University Of Kentucky Research Foundation | Process for enhancing the activity of amyloid β peptides |
| AU753688B2 (en) | 1997-03-10 | 2002-10-24 | Ottawa Civic Loeb Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7264810B2 (en) | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| WO2004087733A2 (en) | 2003-03-28 | 2004-10-14 | New York University | Prevention and treatment of alzheimer amyloid deposition |
| CA2657953A1 (en) | 2005-07-19 | 2007-01-25 | University Of Rochester | Alpha-synuclein antibodies and methods related thereto |
| WO2007103770A2 (en) * | 2006-03-02 | 2007-09-13 | Ppd Biomarker Discovery Sciences, Llc | Compositions and methods for analyzing renal cancer |
| KR20120017469A (ko) | 2007-01-05 | 2012-02-28 | 유니버시티 오브 취리히 | 질환 특이적 결합 분자 및 표적을 제공하는 방법 |
| ATE524487T1 (de) * | 2007-01-11 | 2011-09-15 | Univ Ramot | Tau peptidmimetikum zur behandlung von neurodegenerativen erkrankungen |
| AT506819B1 (de) | 2008-06-12 | 2011-06-15 | Affiris Forschungs Und Entwicklungs Gmbh | Vakzin zur behandlung von alzheimer-krankheit |
| CA3239368A1 (en) * | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| EP2382993A1 (en) * | 2010-04-19 | 2011-11-02 | KTB Tumorforschungsgesellschaft mbH | Combination of drugs with protein-binding prodrugs |
| ES2656442T3 (es) * | 2011-09-19 | 2018-02-27 | Axon Neuroscience Se | Terapia basada en proteínas y diagnóstico de una patología mediada por tau en la enfermedad de Alzheimer |
| US9738709B2 (en) * | 2011-10-21 | 2017-08-22 | Ohio State Innovation Foundation | Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease |
| CA2885924C (en) * | 2012-08-21 | 2022-12-13 | Institute For Molecular Medicine, Inc. | Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein |
| US20170368167A9 (en) * | 2012-08-21 | 2017-12-28 | The Institute For Molecular Medicine | Compositions and methods related to neurological disorders |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
| WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
| CA3003483C (en) | 2015-11-06 | 2022-09-13 | Adjuvance Technologies, Inc. | Triterpene saponin analogues |
| EP3452507B1 (en) | 2016-05-02 | 2022-10-19 | Prothena Biosciences Limited | Tau immunotherapy |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| PE20190208A1 (es) | 2016-05-02 | 2019-02-07 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| CN110506057B (zh) | 2017-02-17 | 2023-09-29 | 百时美施贵宝公司 | Alpha突触核蛋白抗体及其应用 |
| EP3609505A4 (en) | 2017-04-13 | 2021-04-28 | Adjuvance Technologies, Inc. | TRITERPEN-SAPONIN SYNTHESIS, INTERMEDIATES AND COMBINATIONS OF ADJUVANCES |
| CN110730666A (zh) | 2017-04-25 | 2020-01-24 | 佐剂技术公司 | 三萜皂苷类似物 |
| CN110881274B (zh) | 2017-05-02 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| BR112019026707A2 (pt) | 2017-06-16 | 2020-06-30 | United Neuroscience | imunógenos de peptídeo da extremidade c-terminal da proteína alfa-sinucleína e formulações dos mesmos para o tratamento de sinucleinopatias |
| WO2019070480A1 (en) | 2017-10-02 | 2019-04-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | ASSAY FOR DETECTION OF ALPHA-SYNUCLEIN SELF-ACTIVATION ACTIVITY ASSOCIATED WITH SYNUCLEINOPATHIES |
| WO2019070813A2 (en) * | 2017-10-03 | 2019-04-11 | The Trustees Of Columbia University In The City Of New York | USE OF PEPTIDES AS BIOMARKERS IN THE DIAGNOSIS, CONFIRMATION AND TREATMENT OF A NEUROLOGICAL DISORDER |
| WO2019079160A1 (en) | 2017-10-16 | 2019-04-25 | Adjuvance Technologies, Inc. | TRITERPENIC SAPONIN ANALOGS |
| KR20230080397A (ko) * | 2020-08-07 | 2023-06-07 | 오타이르 프로테나 리미티드 | 알츠하이머 질환을 치료하기 위한 멀티에피토프 백신 |
-
2021
- 2021-05-19 WO PCT/US2021/033222 patent/WO2021236809A2/en not_active Ceased
- 2021-05-19 EP EP21809578.4A patent/EP4153210A4/en active Pending
- 2021-05-19 BR BR112022023366A patent/BR112022023366A2/pt unknown
- 2021-05-19 PH PH1/2022/553234A patent/PH12022553234A1/en unknown
- 2021-05-19 KR KR1020227044362A patent/KR20230037501A/ko active Pending
- 2021-05-19 MX MX2022014453A patent/MX2022014453A/es unknown
- 2021-05-19 AU AU2021276401A patent/AU2021276401A1/en active Pending
- 2021-05-19 CA CA3178760A patent/CA3178760A1/en active Pending
- 2021-05-19 US US17/925,813 patent/US20230183304A1/en active Pending
- 2021-05-19 TW TW110118153A patent/TW202208409A/zh unknown
- 2021-05-19 CN CN202180049740.2A patent/CN115867304A/zh active Pending
- 2021-05-19 JP JP2022571167A patent/JP2023526500A/ja active Pending
- 2021-05-19 IL IL298215A patent/IL298215A/en unknown
-
2022
- 2022-11-18 CL CL2022003253A patent/CL2022003253A1/es unknown
- 2022-11-20 JO JOJO/P/2022/0316A patent/JOP20220316A1/ar unknown
-
2023
- 2023-06-02 US US18/328,557 patent/US11965005B2/en active Active
- 2023-06-02 US US18/328,544 patent/US11952406B2/en active Active
- 2023-06-02 US US18/328,528 patent/US11945849B2/en active Active
-
2024
- 2024-03-04 US US18/594,435 patent/US12247056B2/en active Active
-
2025
- 2025-02-27 US US19/064,783 patent/US20250282838A1/en active Pending
- 2025-03-11 CL CL2025000674A patent/CL2025000674A1/es unknown
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