JPWO2022047249A5 - - Google Patents

Info

Publication number

JPWO2022047249A5

JPWO2022047249A5 JP2023513670A JP2023513670A JPWO2022047249A5 JP WO2022047249 A5 JPWO2022047249 A5 JP WO2022047249A5 JP 2023513670 A JP2023513670 A JP 2023513670A JP 2023513670 A JP2023513670 A JP 2023513670A JP WO2022047249 A5 JPWO2022047249 A5 JP WO2022047249A5

Authority

JP

Japan

Prior art keywords

amount

administration

hydroxypropyl

cyclodextrin

therapeutically effective

Prior art date

2024-08-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 22
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 16
• 230000009885 systemic effect Effects 0.000 claims 12
• 201000001320 Atherosclerosis Diseases 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 235000012000 cholesterol Nutrition 0.000 claims 7
• 206010003210 Arteriosclerosis Diseases 0.000 claims 5
• FYHRJWMENCALJY-YSQMORBQSA-N (25R)-cholest-5-ene-3beta,26-diol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCC[C@H](CO)C)[C@@]1(C)CC2 FYHRJWMENCALJY-YSQMORBQSA-N 0.000 claims 4
• DKISDYAXCJJSLZ-UHFFFAOYSA-N 26-Hydroxy-cholesterin Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(CO)C)C1(C)CC2 DKISDYAXCJJSLZ-UHFFFAOYSA-N 0.000 claims 4
• 101150092476 ABCA1 gene Proteins 0.000 claims 4
• 108700005241 ATP Binding Cassette Transporter 1 Proteins 0.000 claims 4
• 102100022594 ATP-binding cassette sub-family G member 1 Human genes 0.000 claims 4
• 108010090314 Member 1 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims 4
• 102100033616 Phospholipid-transporting ATPase ABCA1 Human genes 0.000 claims 4
• 238000001990 intravenous administration Methods 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 239000013078 crystal Substances 0.000 claims 3
• 210000002966 serum Anatomy 0.000 claims 3
• 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 2
• 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 2
• 208000018262 Peripheral vascular disease Diseases 0.000 claims 2
• 239000008186 active pharmaceutical agent Substances 0.000 claims 2
• 208000029078 coronary artery disease Diseases 0.000 claims 2
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
• 238000001802 infusion Methods 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• IOWMKBFJCNLRTC-XWXSNNQWSA-N (24S)-24-hydroxycholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](O)C(C)C)[C@@]1(C)CC2 IOWMKBFJCNLRTC-XWXSNNQWSA-N 0.000 claims 1
• 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 1
• 206010011891 Deafness neurosensory Diseases 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 208000009966 Sensorineural Hearing Loss Diseases 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 230000036765 blood level Effects 0.000 claims 1
• 229940109239 creatinine Drugs 0.000 claims 1
• 210000004185 liver Anatomy 0.000 claims 1
• 231100000879 sensorineural hearing loss Toxicity 0.000 claims 1
• 208000023573 sensorineural hearing loss disease Diseases 0.000 claims 1