JPWO2022010988A5 - - Google Patents
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- Publication number
- JPWO2022010988A5 JPWO2022010988A5 JP2023501015A JP2023501015A JPWO2022010988A5 JP WO2022010988 A5 JPWO2022010988 A5 JP WO2022010988A5 JP 2023501015 A JP2023501015 A JP 2023501015A JP 2023501015 A JP2023501015 A JP 2023501015A JP WO2022010988 A5 JPWO2022010988 A5 JP WO2022010988A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical formulation
- formulation
- syringe
- uplc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 238000009472 formulation Methods 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 239000007864 aqueous solution Substances 0.000 claims 9
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 102000043321 human CTLA4 Human genes 0.000 claims 8
- 229920001213 Polysorbate 20 Polymers 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 5
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 5
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 5
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 5
- 229940068977 polysorbate 20 Drugs 0.000 claims 5
- 239000005720 sucrose Substances 0.000 claims 5
- 238000002372 labelling Methods 0.000 claims 3
- 239000011521 glass Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229940071643 prefilled syringe Drugs 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229940090048 pen injector Drugs 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 239000010937 tungsten Substances 0.000 claims 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063049540P | 2020-07-08 | 2020-07-08 | |
| US63/049,540 | 2020-07-08 | ||
| PCT/US2021/040648 WO2022010988A1 (en) | 2020-07-08 | 2021-07-07 | Stabilized formulations containing anti-ctla-4 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023533963A JP2023533963A (ja) | 2023-08-07 |
| JPWO2022010988A5 true JPWO2022010988A5 (enExample) | 2024-07-16 |
Family
ID=77207237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023501015A Pending JP2023533963A (ja) | 2020-07-08 | 2021-07-07 | 抗ｃｔｌａ－４抗体を含む安定化製剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220031843A1 (enExample) |
| EP (1) | EP4178983A1 (enExample) |
| JP (1) | JP2023533963A (enExample) |
| KR (1) | KR20230035595A (enExample) |
| CN (1) | CN115812080A (enExample) |
| AU (1) | AU2021305093A1 (enExample) |
| CA (1) | CA3185091A1 (enExample) |
| IL (1) | IL299152A (enExample) |
| MX (1) | MX2022016218A (enExample) |
| WO (1) | WO2022010988A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11525629B2 (en) | 2020-02-04 | 2022-12-13 | Regeneron Pharmaceuticals, Inc. | Target residual moisture content for lyophilized drug product |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0747045B2 (ja) | 1986-10-15 | 1995-05-24 | 株式会社大協精工 | 積層した注射器用滑栓 |
| JP3100727B2 (ja) | 1992-01-23 | 2000-10-23 | 株式会社大協精工 | 変性ポリシロキサン組成物及び該組成物を被覆した衛生ゴム製品 |
| JP3172057B2 (ja) | 1995-04-05 | 2001-06-04 | 株式会社大協精工 | ラミネートゴム栓 |
| JP3512349B2 (ja) | 1999-01-29 | 2004-03-29 | 株式会社大協精工 | 柱状ゴム要素の成形型 |
| JP2002209975A (ja) | 2001-01-19 | 2002-07-30 | Daikyo Seiko Ltd | 医薬バイアル用ラミネートゴム栓 |
| JO3417B1 (ar) * | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
| KR101867279B1 (ko) * | 2010-10-06 | 2018-06-15 | 리제너론 파아마슈티컬스, 인크. | 항―인터류킨―４ 수용체（ｉｌ－４ｒ） 항체를 함유하는 안정화된 제형 |
| AR087305A1 (es) * | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| MY164611A (en) * | 2012-01-23 | 2018-01-30 | Regeneron Pharma | Stabilized formulations containing anti-ang2 antibodies |
| EP2633874A1 (en) * | 2012-03-02 | 2013-09-04 | Sanofi-Aventis Deutschland GmbH | Fixed-dose medicament delivery device |
| AR092325A1 (es) * | 2012-05-31 | 2015-04-15 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-dll4 y kit |
| NZ735820A (en) * | 2015-04-17 | 2025-02-28 | Bristol Myers Squibb Co | Compositions comprising a combination of an anti-pd-1 antibody and another antibody |
| MA50501A (fr) * | 2017-05-02 | 2020-09-09 | Merck Sharp & Dohme | Formulations stables d'anticorps anti-ctla4 seuls et en combinaison avec des anticorps anti-récepteur de mort programmée 1 (pd-1) et leurs procédés d'utilisation |
| TWI799432B (zh) * | 2017-07-27 | 2023-04-21 | 美商再生元醫藥公司 | 抗ctla-4抗體及其用途 |
| US20210317220A1 (en) * | 2018-09-24 | 2021-10-14 | Janssen Biotech, Inc. | Method of providing safe administration of an anti-cd154 antibody |
| EP4082572A4 (en) * | 2019-12-25 | 2024-03-06 | Bio-Thera Solutions, Ltd. | ANTI-CTLA-4 MONOCLONAL ANTIBODY, PREPARATION METHOD AND ITS APPLICATION |
-
2021
- 2021-07-07 AU AU2021305093A patent/AU2021305093A1/en active Pending
- 2021-07-07 IL IL299152A patent/IL299152A/en unknown
- 2021-07-07 MX MX2022016218A patent/MX2022016218A/es unknown
- 2021-07-07 EP EP21749919.3A patent/EP4178983A1/en active Pending
- 2021-07-07 US US17/369,321 patent/US20220031843A1/en not_active Abandoned
- 2021-07-07 CN CN202180049075.7A patent/CN115812080A/zh active Pending
- 2021-07-07 JP JP2023501015A patent/JP2023533963A/ja active Pending
- 2021-07-07 KR KR1020237003824A patent/KR20230035595A/ko active Pending
- 2021-07-07 WO PCT/US2021/040648 patent/WO2022010988A1/en not_active Ceased
- 2021-07-07 CA CA3185091A patent/CA3185091A1/en active Pending
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