JPWO2021263124A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021263124A5 JPWO2021263124A5 JP2022580043A JP2022580043A JPWO2021263124A5 JP WO2021263124 A5 JPWO2021263124 A5 JP WO2021263124A5 JP 2022580043 A JP2022580043 A JP 2022580043A JP 2022580043 A JP2022580043 A JP 2022580043A JP WO2021263124 A5 JPWO2021263124 A5 JP WO2021263124A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- ires
- protein
- circular rna
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028075 Circular RNA Proteins 0.000 claims 37
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 36
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 31
- 150000007523 nucleic acids Chemical group 0.000 claims 31
- 108091033319 polynucleotide Proteins 0.000 claims 25
- 102000040430 polynucleotide Human genes 0.000 claims 25
- 239000002157 polynucleotide Substances 0.000 claims 25
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 15
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 108020004463 18S ribosomal RNA Proteins 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 11
- 230000000295 complement effect Effects 0.000 claims 11
- 108091034117 Oligonucleotide Proteins 0.000 claims 10
- 125000006850 spacer group Chemical group 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 3
- 101710159080 Aconitate hydratase A Proteins 0.000 claims 2
- 101710159078 Aconitate hydratase B Proteins 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- 108700011259 MicroRNAs Proteins 0.000 claims 2
- 102000044126 RNA-Binding Proteins Human genes 0.000 claims 2
- 101710105008 RNA-binding protein Proteins 0.000 claims 2
- 108091081024 Start codon Proteins 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108020004418 ribosomal RNA Proteins 0.000 claims 2
- 238000005096 rolling process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 241000175212 Herpesvirales Species 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063043964P | 2020-06-25 | 2020-06-25 | |
| US63/043,964 | 2020-06-25 | ||
| US202163186507P | 2021-05-10 | 2021-05-10 | |
| US63/186,507 | 2021-05-10 | ||
| PCT/US2021/039127 WO2021263124A2 (en) | 2020-06-25 | 2021-06-25 | Genetic elements driving circular rna translation and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023532663A JP2023532663A (ja) | 2023-07-31 |
| JPWO2021263124A5 true JPWO2021263124A5 (ru) | 2024-07-02 |
Family
ID=79281918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022580043A Pending JP2023532663A (ja) | 2020-06-25 | 2021-06-25 | 環状ｒｎａ翻訳を駆動する遺伝エレメント及び使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11560567B2 (ru) |
| EP (1) | EP4171631A2 (ru) |
| JP (1) | JP2023532663A (ru) |
| KR (1) | KR20230028375A (ru) |
| CN (1) | CN116323945A (ru) |
| AU (1) | AU2021297340A1 (ru) |
| CA (1) | CA3180224A1 (ru) |
| WO (1) | WO2021263124A2 (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3207655A1 (en) * | 2021-02-09 | 2022-08-18 | Guizhi ZHU | Mini circular rna therapeutics and vaccines and methods of use thereof |
| EP4436983A1 (en) | 2021-11-24 | 2024-10-02 | Flagship Pioneering Innovations VI, LLC | Varicella-zoster virus immunogen compositions and their uses |
| KR20240122785A (ko) | 2021-11-24 | 2024-08-13 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 면역원성 조성물 및 이의 용도 |
| EP4436984A1 (en) | 2021-11-24 | 2024-10-02 | Flagship Pioneering Innovations VI, LLC | Coronavirus immunogen compositions and their uses |
| AU2022413687A1 (en) | 2021-12-17 | 2024-06-27 | Flagship Pioneering Innovations Vi, Llc | Methods for enrichment of circular rna under denaturing conditions |
| AU2022417517A1 (en) | 2021-12-22 | 2024-06-27 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| WO2023122789A1 (en) | 2021-12-23 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
| WO2023161159A1 (en) * | 2022-02-24 | 2023-08-31 | Probiogen Ag | Circular rna-delivery mediated by virus like particles |
| TW202345862A (zh) * | 2022-03-17 | 2023-12-01 | 李蘭史丹佛學院理事會 | 利用重組環狀rna改善蛋白質轉譯的組合物及方法 |
| WO2023231959A2 (en) | 2022-05-30 | 2023-12-07 | Shanghai Circode Biomed Co., Ltd | Synthetic circular rna compositions and methods of use thereof |
| WO2023250528A1 (en) * | 2022-06-24 | 2023-12-28 | The Broad Institute, Inc. | Compositions and methods for preparing capped circular rna molecules |
| WO2024006765A2 (en) * | 2022-06-27 | 2024-01-04 | Wisconsin Alumni Research Foundation | Universal method for parasite and eukaryotic endosymbiont identification |
| WO2024010028A1 (ja) * | 2022-07-06 | 2024-01-11 | 国立大学法人京都大学 | 環状ｒｎａ分子及びこれを用いた翻訳制御方法、翻訳活性化システム、並びに医薬組成物 |
| CN115394376B (zh) * | 2022-09-28 | 2023-04-18 | 奥明(杭州)生物医药有限公司 | 一种预测环状rna ires的方法 |
| WO2024102799A1 (en) | 2022-11-08 | 2024-05-16 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for producing circular polyribonucleotides |
| WO2024151583A2 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
| WO2024159172A1 (en) | 2023-01-27 | 2024-08-02 | Senda Biosciences, Inc. | A modified lipid composition and uses thereof |
| US20240269263A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
| WO2024192422A1 (en) | 2023-03-15 | 2024-09-19 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
| WO2024192420A1 (en) | 2023-03-15 | 2024-09-19 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising polyribonucleotides and uses thereof |
| WO2024220625A1 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024220712A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Vaccine compositions |
| WO2024220752A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Rna therapeutic compositions |
| WO2024226621A1 (en) * | 2023-04-25 | 2024-10-31 | Ginkgo Bioworks, Inc. | Novel internal ribosome entry site (ires) and intron sequences |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766903A (en) * | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
| DE10162480A1 (de) | 2001-12-19 | 2003-08-07 | Ingmar Hoerr | Die Applikation von mRNA für den Einsatz als Therapeutikum gegen Tumorerkrankungen |
| WO2010084371A1 (en) | 2009-01-26 | 2010-07-29 | Mitoprod | Novel circular interfering rna molecules |
| US8790879B2 (en) * | 2010-01-22 | 2014-07-29 | Gen-Probe Incorporated | Probes for detecting the presence of Trichomonas vaginalis in a sample |
| DK2925866T3 (en) | 2012-11-30 | 2018-10-29 | Univ Aarhus | CIRCULAR RNA FOR INHIBITING MICRO-RNA |
| WO2014186334A1 (en) | 2013-05-15 | 2014-11-20 | Robert Kruse | Intracellular translation of circular rna |
| CA2955238A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3374504A2 (en) * | 2015-11-09 | 2018-09-19 | CureVac AG | Optimized nucleic acid molecules |
| CA3028682A1 (en) | 2016-06-20 | 2017-12-28 | Howard Y. Chang | Circular rnas and their use in immunomodulation |
| AU2019312269A1 (en) * | 2018-07-24 | 2021-03-04 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| CN114258430A (zh) | 2019-04-22 | 2022-03-29 | T细胞受体治疗公司 | 使用融合蛋白进行tcr重编程的组合物和方法 |
-
2021
- 2021-06-25 WO PCT/US2021/039127 patent/WO2021263124A2/en unknown
- 2021-06-25 AU AU2021297340A patent/AU2021297340A1/en active Pending
- 2021-06-25 CN CN202180052292.1A patent/CN116323945A/zh active Pending
- 2021-06-25 KR KR1020237001270A patent/KR20230028375A/ko active Search and Examination
- 2021-06-25 EP EP21829176.3A patent/EP4171631A2/en active Pending
- 2021-06-25 CA CA3180224A patent/CA3180224A1/en active Pending
- 2021-06-25 JP JP2022580043A patent/JP2023532663A/ja active Pending
-
2022
- 2022-03-16 US US17/696,606 patent/US11560567B2/en active Active
- 2022-10-03 US US17/937,617 patent/US11685924B2/en active Active
-
2023
- 2023-06-23 US US18/340,582 patent/US20230407317A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2021263124A5 (ru) | ||
| TW202136508A (zh) | 用於編輯目標rna之附加有功能性領域之反義型嚮導rna | |
| JP2012509678A5 (ru) | ||
| JPWO2022067130A5 (ru) | ||
| CA2336227A1 (en) | Genes involved in tolerance to environmental stress | |
| EP3778892A1 (en) | Novel small activating rna | |
| WO2020061397A1 (en) | Compositions and methods for delivery of nucleic acids | |
| CN112996913A (zh) | 寡聚核酸分子及其应用 | |
| JP2023002469A (ja) | 抗ウイルス及び抗がんワクチンに用いる新規なｍＲＮＡ組成物及びその製造方法 | |
| KR20200143428A (ko) | P21 유전자 발현을 활성화하는 방법 | |
| CN116262926B (zh) | 一种非加帽线性rna重组核酸分子及其应用 | |
| JPWO2022051020A5 (ru) | ||
| JPWO2021142458A5 (ru) | ||
| CN116981773A (zh) | 用于编辑靶标rna的多聚腺苷酸化信号序列的指导rna | |
| WO2018165929A1 (zh) | 一种双miRNA抑制表达载体及其构建方法和应用 | |
| WO2021249064A1 (zh) | 靶向mitf基因的核酸分子及其用途 | |
| CN114410644B (zh) | 一种环状rna分子及应用 | |
| WO2024188312A1 (en) | Compositions and methods for enhanced protein expression | |
| JP2008503569A5 (ru) | ||
| US20230220390A1 (en) | Nucleic acid molecule having improved stability, and use thereof | |
| CN115786338A (zh) | 一种i型内含子核酶、其制备方法和在调控rna成环中的应用 | |
| JPH05502580A (ja) | 細菌での触媒ｒｎａの製造法 | |
| RU2495127C2 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДА pAd-SM, КОДИРУЮЩАЯ БЕЛКИ SOX2 И C-MYC ЧЕЛОВЕКА, ЯВЛЯЮЩАЯСЯ ОСНОВОЙ ДЛЯ ПОЛУЧЕНИЯ ВИРУЛЕНТНЫХ АДЕНОВИРУСОВ, ПРЕДНАЗНАЧЕННЫХ ДЛЯ ПОЛУЧЕНИЯ ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ КЛЕТОК ЧЕЛОВЕКА | |
| Danish | A novel Adenoviral miRNA, a candidate for development of a novel gene therapy startegy | |
| JP2024522216A (ja) | インフラマソーム関連疾患または障害を治療するためのｍｉｒｎａ－４８５阻害剤の使用 |