JPWO2021261483A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021261483A5 JPWO2021261483A5 JP2022532492A JP2022532492A JPWO2021261483A5 JP WO2021261483 A5 JPWO2021261483 A5 JP WO2021261483A5 JP 2022532492 A JP2022532492 A JP 2022532492A JP 2022532492 A JP2022532492 A JP 2022532492A JP WO2021261483 A5 JPWO2021261483 A5 JP WO2021261483A5
- Authority
- JP
- Japan
- Prior art keywords
- pbs
- judgment value
- antibody
- tween
- normalized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000136 polysorbate Polymers 0.000 description 10
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000002965 ELISA Methods 0.000 description 7
- 102000021095 WAP Four-Disulfide Core Domain Protein 2 Human genes 0.000 description 6
- 108091002660 WAP Four-Disulfide Core Domain Protein 2 Proteins 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 229940109239 creatinine Drugs 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 2
- 241000283074 Equus asinus Species 0.000 description 2
- 101710176384 Peptide 1 Proteins 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 102000013415 peroxidase activity proteins Human genes 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
- 210000004897 n-terminal region Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020108265 | 2020-06-23 | ||
| PCT/JP2021/023578 WO2021261483A1 (ja) | 2020-06-23 | 2021-06-22 | 腺癌の検出方法及び検査キット |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021261483A1 JPWO2021261483A1 (https=) | 2021-12-30 |
| JPWO2021261483A5 true JPWO2021261483A5 (https=) | 2023-04-28 |
Family
ID=79281199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022532492A Pending JPWO2021261483A1 (https=) | 2020-06-23 | 2021-06-22 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230243835A1 (https=) |
| EP (1) | EP4169941A4 (https=) |
| JP (1) | JPWO2021261483A1 (https=) |
| WO (1) | WO2021261483A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3202255A1 (en) | 2020-12-21 | 2022-06-30 | Hayley WARSINSKE | Markers for the early detection of colon cell proliferative disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
| US7811778B2 (en) * | 2006-09-06 | 2010-10-12 | Vanderbilt University | Methods of screening for gastrointestinal cancer |
| RU2650778C2 (ru) * | 2011-02-17 | 2018-04-17 | Фуджиребио Диагностикс, Инк | Композиции и способы применения для определения не4а |
| WO2012170513A2 (en) * | 2011-06-06 | 2012-12-13 | Women & Infants' Hospital Of Rhode Island | He4 based therapy for malignant disease |
| ES2792055T3 (es) * | 2015-12-17 | 2020-11-06 | Hoffmann La Roche | Métodos de detección de una recidiva de un adenocarcinoma de pulmón basándose en la proteína 4 del epidídimo humano (HE 4) marcadora y usos relacionados |
| WO2017142025A1 (ja) * | 2016-02-19 | 2017-08-24 | 国立大学法人宮崎大学 | 腺癌の検出方法 |
| WO2018225830A1 (ja) * | 2017-06-08 | 2018-12-13 | 国立大学法人宮崎大学 | 肺がんの検出方法 |
-
2021
- 2021-06-22 US US18/002,344 patent/US20230243835A1/en active Pending
- 2021-06-22 WO PCT/JP2021/023578 patent/WO2021261483A1/ja not_active Ceased
- 2021-06-22 JP JP2022532492A patent/JPWO2021261483A1/ja active Pending
- 2021-06-22 EP EP21829606.9A patent/EP4169941A4/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6408051B2 (ja) | 病理学バイオマーカーアッセイ | |
| CN101641601B (zh) | 用于bnp免疫测定法的稳定标准品 | |
| US9034592B2 (en) | Immunoassay for quantification of an unstable antigen selected from BNP and proBNP | |
| CN115836223A (zh) | 钙防卫蛋白测定 | |
| KR102245938B1 (ko) | 진단 분석에 사용하기 위한 개선된 rep 단백질 | |
| JP2024056971A (ja) | APP669-xのN末端を特異的に認識する抗体、及び免疫測定法 | |
| JPWO2021261483A5 (https=) | ||
| JP6175058B2 (ja) | チチンタンパク質のネオエピトープアッセイによる心血管イベントのインビトロ評価 | |
| CN110114676B (zh) | 肾素浓度的免疫学测定方法 | |
| JP2017504040A (ja) | 肺疾患および他の疾患用の生化学マーカー | |
| EP4070112A1 (en) | A neo-epitope specific assay measuring protease mediated degradation of type iv collagen | |
| JP2018080114A (ja) | 抗ヒトvap−1モノクローナル抗体 | |
| WO2021253335A1 (zh) | 抗可溶性cd14亚型抗体、试剂盒及其应用 | |
| US20240011997A1 (en) | Elastin Assay | |
| US20250076313A1 (en) | Anastellin Biomarker | |
| Altshuler et al. | Application of recombinant antibody fragments for troponin I measurements | |
| WO2019167128A1 (ja) | サンドイッチ型免疫測定法 | |
| WO2024219421A1 (ja) | NT-proBNPに対する抗体、これを用いたNT-proBNP検出方法、並びに、NT-proBNP検出に用いるための組成物及びキット | |
| CA3210996A1 (en) | Anastellin biomarker | |
| JPWO2023277122A5 (https=) | ||
| WO2020179224A1 (ja) | App669-711の測定方法、及び測定用キット | |
| HK1147801B (en) | Immunoassay for quantification of an unstable antigen selected from bnp and probnp | |
| HK1147801A (en) | Immunoassay for quantification of an unstable antigen selected from bnp and probnp |