JPWO2021204762A5 - - Google Patents
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- Publication number
- JPWO2021204762A5 JPWO2021204762A5 JP2022559959A JP2022559959A JPWO2021204762A5 JP WO2021204762 A5 JPWO2021204762 A5 JP WO2021204762A5 JP 2022559959 A JP2022559959 A JP 2022559959A JP 2022559959 A JP2022559959 A JP 2022559959A JP WO2021204762 A5 JPWO2021204762 A5 JP WO2021204762A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- compound
- formula
- crystal
- diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 22
- 239000013078 crystal Substances 0.000 claims 21
- 238000001816 cooling Methods 0.000 claims 8
- 238000010438 heat treatment Methods 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- 239000000843 powder Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 238000011067 equilibration Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 108010010057 TYK2 Kinase Proteins 0.000 claims 1
- 102000015774 TYK2 Kinase Human genes 0.000 claims 1
- -1 aliphatic ketones Chemical class 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 150000008378 aryl ethers Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 150000008282 halocarbons Chemical class 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims 1
- 229940011051 isopropyl acetate Drugs 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2005114.0 | 2020-04-07 | ||
| GBGB2005114.0A GB202005114D0 (en) | 2020-04-07 | 2020-04-07 | Crystalline Forms of a Pharmaceutical Compound |
| PCT/EP2021/058864 WO2021204762A1 (en) | 2020-04-07 | 2021-04-06 | Crystalline forms of a tyk2 inhibitor |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023521631A JP2023521631A (ja) | 2023-05-25 |
| JPWO2021204762A5 true JPWO2021204762A5 (https=) | 2024-04-01 |
| JP2023521631A5 JP2023521631A5 (https=) | 2024-04-01 |
| JP7660135B2 JP7660135B2 (ja) | 2025-04-10 |
Family
ID=70768933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559959A Active JP7660135B2 (ja) | 2020-04-07 | 2021-04-06 | Ｔｙｋ２阻害剤の結晶形態 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12545652B2 (https=) |
| EP (1) | EP4132649A1 (https=) |
| JP (1) | JP7660135B2 (https=) |
| KR (1) | KR20220164751A (https=) |
| CN (1) | CN115515683B (https=) |
| AU (1) | AU2021253128A1 (https=) |
| BR (1) | BR112022016359A2 (https=) |
| CA (1) | CA3167172A1 (https=) |
| GB (1) | GB202005114D0 (https=) |
| IL (1) | IL296989A (https=) |
| MX (1) | MX2022011593A (https=) |
| WO (1) | WO2021204762A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| CN118974052A (zh) * | 2022-03-25 | 2024-11-15 | 武田药品工业株式会社 | Tyk2抑制剂的固体形式和使用方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794096A (fr) | 1972-08-07 | 1973-05-16 | Lepetit Spa | Oxazoles 2,4,5-trisubstitues et leur preparation |
| GB1497536A (en) | 1973-12-17 | 1978-01-12 | Lilly Industries Ltd | 2-acylaminooxazoles methods for their preparation and their use |
| JPH0753716B2 (ja) | 1986-07-02 | 1995-06-07 | 吉富製薬株式会社 | イミダゾ−ルカルボキサミド誘導体 |
| DE19653355A1 (de) | 1996-12-20 | 1998-06-25 | Dresden Arzneimittel | Neue, antikonvulsiv wirkende Aminoimidazole und Verfahren zu ihrer Herstellung |
| GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| ATE394102T1 (de) | 2000-06-28 | 2008-05-15 | Astrazeneca Ab | Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren |
| CN100400040C (zh) | 2000-10-30 | 2008-07-09 | 詹森药业有限公司 | 三肽酶抑制剂 |
| CA2491895C (en) | 2002-07-09 | 2011-01-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| EP1684750B1 (en) | 2003-10-23 | 2010-04-28 | AB Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
| GB0504753D0 (en) | 2005-03-08 | 2005-04-13 | Astrazeneca Ab | Chemical compounds |
| KR20080066938A (ko) | 2005-10-07 | 2008-07-17 | 깃세이 야쿠힌 고교 가부시키가이샤 | 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물 |
| ES2352320T3 (es) | 2006-05-12 | 2011-02-17 | Ab Science | Nuevo procedimiento para la síntesis de compuestos de 2-aminoxazol. |
| US20090093452A1 (en) | 2006-08-24 | 2009-04-09 | Pfizer Inc. | Pyrrole, Thiophene, Furan, Imidazole, Oxazole, and Thiazole Derivatives |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| ES2395581T3 (es) | 2007-06-20 | 2013-02-13 | Merck Sharp & Dohme Corp. | Inhibidores de quinasas janus |
| US8278335B2 (en) | 2008-04-21 | 2012-10-02 | Merck Sharp & Dohme Corp. | Inhibitors of Janus kinases |
| WO2009155156A1 (en) | 2008-06-18 | 2009-12-23 | Merck & Co., Inc. | Inhibitors of janus kinases |
| EP2310384B1 (en) | 2008-07-09 | 2014-04-09 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| EP2166006A1 (en) | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
| CA2793024A1 (en) | 2010-03-17 | 2011-09-22 | F. Hoffmann-La Roche Ag | Imidazopyridine compounds, compositions and methods of use |
| EP2588105A1 (en) | 2010-07-01 | 2013-05-08 | Cellzome Limited | Triazolopyridines as tyk2 inhibitors |
| WO2012021611A1 (en) | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US20140228349A1 (en) | 2011-10-12 | 2014-08-14 | Array Biopharma Inc. | 5,7-substituted-imidazo[1,2-c]pyrimidines |
| DK2634185T3 (en) | 2012-03-02 | 2016-03-21 | Sareum Ltd | Tyk2 kinase inhibitors |
| KR101202026B1 (ko) | 2012-07-03 | 2012-11-16 | 민호현 | 황토 석부작 제조 방법 |
| MY194668A (en) | 2012-11-08 | 2022-12-12 | Bristol Myers Squibb Co | Amide-substituted heterocyclic compounds useful as modulators of il-12, il-23 and/or ifn() responses |
| RU2652795C2 (ru) * | 2013-09-03 | 2018-05-03 | Сареум Лимитед | Производные 2-фенил-оксазол-4-карбоксамида, модулирующие активность jak и tyk2 киназ |
| NO2721710T3 (https=) | 2014-08-21 | 2018-03-31 | ||
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
-
2020
- 2020-04-07 GB GBGB2005114.0A patent/GB202005114D0/en not_active Ceased
-
2021
- 2021-04-06 WO PCT/EP2021/058864 patent/WO2021204762A1/en not_active Ceased
- 2021-04-06 CA CA3167172A patent/CA3167172A1/en active Pending
- 2021-04-06 MX MX2022011593A patent/MX2022011593A/es unknown
- 2021-04-06 KR KR1020227038120A patent/KR20220164751A/ko active Pending
- 2021-04-06 AU AU2021253128A patent/AU2021253128A1/en active Pending
- 2021-04-06 US US17/905,183 patent/US12545652B2/en active Active
- 2021-04-06 EP EP21717041.4A patent/EP4132649A1/en active Pending
- 2021-04-06 IL IL296989A patent/IL296989A/en unknown
- 2021-04-06 CN CN202180025999.3A patent/CN115515683B/zh active Active
- 2021-04-06 BR BR112022016359A patent/BR112022016359A2/pt unknown
- 2021-04-06 JP JP2022559959A patent/JP7660135B2/ja active Active
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