JPWO2021183563A5 - - Google Patents
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- JPWO2021183563A5 JPWO2021183563A5 JP2022554681A JP2022554681A JPWO2021183563A5 JP WO2021183563 A5 JPWO2021183563 A5 JP WO2021183563A5 JP 2022554681 A JP2022554681 A JP 2022554681A JP 2022554681 A JP2022554681 A JP 2022554681A JP WO2021183563 A5 JPWO2021183563 A5 JP WO2021183563A5
- Authority
- JP
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- Prior art keywords
- lipid
- composition
- mol
- nucleic acid
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 63
- 150000002632 lipids Chemical class 0.000 claims 46
- 102000039446 nucleic acids Human genes 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 238000009472 formulation Methods 0.000 claims 22
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 241000710929 Alphavirus Species 0.000 claims 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 11
- 239000002105 nanoparticle Substances 0.000 claims 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 8
- -1 cationic lipid Chemical class 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 6
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 6
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 5
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 5
- 230000000890 antigenic effect Effects 0.000 claims 5
- 235000012000 cholesterol Nutrition 0.000 claims 5
- 239000005720 sucrose Substances 0.000 claims 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 229920001983 poloxamer Polymers 0.000 claims 4
- 229960000502 poloxamer Drugs 0.000 claims 4
- 108091029795 Intergenic region Proteins 0.000 claims 3
- 101710150114 Protein rep Proteins 0.000 claims 3
- 101710152114 Replication protein Proteins 0.000 claims 3
- 239000007983 Tris buffer Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
- 230000029812 viral genome replication Effects 0.000 claims 3
- CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 2
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- 239000007995 HEPES buffer Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 108010076039 Polyproteins Proteins 0.000 claims 2
- 101800000980 Protease nsP2 Proteins 0.000 claims 2
- 101800001758 RNA-directed RNA polymerase nsP4 Proteins 0.000 claims 2
- 101000629318 Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Proteins 0.000 claims 2
- 108091023045 Untranslated Region Proteins 0.000 claims 2
- 108700004885 alphavirus nsp3 Proteins 0.000 claims 2
- 239000002577 cryoprotective agent Substances 0.000 claims 2
- 229960003724 dimyristoylphosphatidylcholine Drugs 0.000 claims 2
- 229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 claims 2
- MWRBNPKJOOWZPW-CLFAGFIQSA-N dioleoyl phosphatidylethanolamine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-CLFAGFIQSA-N 0.000 claims 2
- BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 claims 2
- 229920001993 poloxamer 188 Polymers 0.000 claims 2
- 229940044519 poloxamer 188 Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229940069338 potassium sorbate Drugs 0.000 claims 2
- 235000010241 potassium sorbate Nutrition 0.000 claims 2
- 239000004302 potassium sorbate Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 208000025721 COVID-19 Diseases 0.000 claims 1
- 108020004705 Codon Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
- 108091005774 SARS-CoV-2 proteins Proteins 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 108700010904 coronavirus proteins Proteins 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 210000001808 exosome Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000003904 phospholipids Chemical group 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229960004793 sucrose Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062987191P | 2020-03-09 | 2020-03-09 | |
| US62/987,191 | 2020-03-09 | ||
| US202063073900P | 2020-09-02 | 2020-09-02 | |
| US63/073,900 | 2020-09-02 | ||
| PCT/US2021/021572 WO2021183563A1 (en) | 2020-03-09 | 2021-03-09 | Coronavirus vaccine compositions and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023517644A JP2023517644A (ja) | 2023-04-26 |
| JPWO2021183563A5 true JPWO2021183563A5 (https=) | 2024-03-18 |
| JP2023517644A5 JP2023517644A5 (https=) | 2024-03-18 |
Family
ID=77671984
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022554681A Pending JP2023517644A (ja) | 2020-03-09 | 2021-03-09 | コロナウイルスワクチン組成物及び方法 |
| JP2022554368A Pending JP2023519173A (ja) | 2020-03-09 | 2021-03-09 | 免疫応答を誘導するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022554368A Pending JP2023519173A (ja) | 2020-03-09 | 2021-03-09 | 免疫応答を誘導するための組成物及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US11759515B2 (https=) |
| EP (2) | EP4117720A4 (https=) |
| JP (2) | JP2023517644A (https=) |
| AU (2) | AU2021233816A1 (https=) |
| CA (2) | CA3171231A1 (https=) |
| TW (1) | TW202200605A (https=) |
| WO (2) | WO2021183563A1 (https=) |
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