JPWO2021125311A5 - - Google Patents
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- Publication number
- JPWO2021125311A5 JPWO2021125311A5 JP2021565671A JP2021565671A JPWO2021125311A5 JP WO2021125311 A5 JPWO2021125311 A5 JP WO2021125311A5 JP 2021565671 A JP2021565671 A JP 2021565671A JP 2021565671 A JP2021565671 A JP 2021565671A JP WO2021125311 A5 JPWO2021125311 A5 JP WO2021125311A5
- Authority
- JP
- Japan
- Prior art keywords
- base sequence
- region
- bases
- exon
- antisense oligomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019229763 | 2019-12-19 | ||
| JP2019229763 | 2019-12-19 | ||
| PCT/JP2020/047340 WO2021125311A1 (ja) | 2019-12-19 | 2020-12-18 | エクソンスキッピングを可能にするアンチセンス核酸 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021125311A1 JPWO2021125311A1 (https=) | 2021-06-24 |
| JPWO2021125311A5 true JPWO2021125311A5 (https=) | 2023-12-18 |
| JP7842395B2 JP7842395B2 (ja) | 2026-04-08 |
Family
ID=76478794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021565671A Active JP7842395B2 (ja) | 2019-12-19 | 2020-12-18 | エクソンスキッピングを可能にするアンチセンス核酸 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230045557A1 (https=) |
| EP (1) | EP4079329A4 (https=) |
| JP (1) | JP7842395B2 (https=) |
| KR (1) | KR20220118459A (https=) |
| CN (1) | CN115151642A (https=) |
| AU (1) | AU2020408773A1 (https=) |
| BR (1) | BR112022012114A2 (https=) |
| CA (1) | CA3165316A1 (https=) |
| CO (1) | CO2022009983A2 (https=) |
| IL (1) | IL293997A (https=) |
| MX (1) | MX2022007491A (https=) |
| PH (1) | PH12022551438A1 (https=) |
| TW (1) | TW202136511A (https=) |
| WO (1) | WO2021125311A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4363578A1 (en) * | 2021-07-02 | 2024-05-08 | Aarhus Universitet | Methods of treating alzheimer's disease |
| JP2025079347A (ja) * | 2022-03-11 | 2025-05-22 | 日本新薬株式会社 | キャリアペプチドが連結された核酸 |
| EP4680250A1 (en) * | 2023-03-17 | 2026-01-21 | The Regents of the University of California | Factor viii splice-modulating antisense oligonucleotides and methods of use |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU655164B2 (en) | 1989-12-20 | 1994-12-08 | Antivirals Inc. | Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages |
| JP2924179B2 (ja) | 1993-02-19 | 1999-07-26 | 日本新薬株式会社 | グリセロール誘導体，デバイス及び医薬組成物 |
| EP2392660A3 (en) | 2002-11-25 | 2012-03-28 | Masafumi Matsuo | ENA Nucleic Acid Drugs Modifying Splicing in mRNA Precursor |
| AU2003225410A1 (en) * | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| EP2933332A1 (en) | 2004-06-28 | 2015-10-21 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
| EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
| ES2639852T3 (es) * | 2007-10-26 | 2017-10-30 | Academisch Ziekenhuis Leiden | Medios y métodos para contrarrestar los trastornos musculares |
| RU2606627C2 (ru) | 2007-11-15 | 2017-01-10 | Серепта Терапьютикс,Инк. | Способ синтеза морфолиновых олигомеров |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| US8084601B2 (en) | 2008-09-11 | 2011-12-27 | Royal Holloway And Bedford New College Royal Holloway, University Of London | Oligomers |
| BR122020021379B1 (pt) | 2008-10-24 | 2021-05-11 | Sarepta Therapeutics, Inc. | oligômero morfolino fosforodiamidato, composição que compreende o mesmo e uso do dito oligômero para tratar distrofia muscular |
| AU2009310557B2 (en) * | 2008-10-27 | 2014-09-11 | Academisch Ziekenhuis Leiden | Methods and means for efficient skipping of exon 45 in Duchenne Muscular Dystrophy pre-mRNA |
| TR201816523T4 (tr) | 2009-11-12 | 2018-11-21 | Univ Western Australia | Patolojilerin tedavisine yönelik antisens moleküller ve yöntemler. |
| TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| CA2861247C (en) | 2011-12-28 | 2021-11-16 | Nippon Shinyaku Co., Ltd. | Antisense nucleic acids |
| NZ627896A (en) * | 2012-01-27 | 2016-11-25 | Biomarin Technologies B V | Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy |
| CN110218727A (zh) * | 2013-03-14 | 2019-09-10 | 萨勒普塔医疗公司 | 用于治疗肌营养不良的外显子跳跃组合物 |
| DK3118311T3 (en) * | 2014-03-12 | 2019-03-11 | Nippon Shinyaku Co Ltd | Antisense nucleic acid |
| HUE050061T2 (hu) * | 2015-09-15 | 2020-12-28 | Nippon Shinyaku Co Ltd | Antiszensz nukleinsav |
| MX2019008199A (es) * | 2017-01-06 | 2019-11-25 | Avidity Biosciences Llc | Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon. |
| MX2020003130A (es) * | 2017-09-22 | 2020-09-25 | Avidity Biosciences Inc | Composiciones y metodos de induccion de salto de exon en acidos nucleicos-polipeptidos. |
| EP3735462A1 (en) * | 2018-01-05 | 2020-11-11 | The Board of Regents of The University of Texas System | Therapeutic crispr/cas9 compositions and methods of use |
| SG11202009877XA (en) * | 2018-04-12 | 2020-11-27 | Wave Life Sciences Ltd | Oligonucleotide compositions and methods of use thereof |
| CA3108282A1 (en) * | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| CN114901823A (zh) * | 2019-12-26 | 2022-08-12 | 日本新药株式会社 | 诱导外显子50的跳读的反义核酸 |
| IL295967A (en) * | 2020-02-28 | 2022-10-01 | Nippon Shinyaku Co Ltd | Antisense nucleic acids for splicing on exon 51 |
-
2020
- 2020-12-18 IL IL293997A patent/IL293997A/en unknown
- 2020-12-18 AU AU2020408773A patent/AU2020408773A1/en active Pending
- 2020-12-18 PH PH1/2022/551438A patent/PH12022551438A1/en unknown
- 2020-12-18 US US17/785,565 patent/US20230045557A1/en active Pending
- 2020-12-18 EP EP20901000.8A patent/EP4079329A4/en active Pending
- 2020-12-18 KR KR1020227023507A patent/KR20220118459A/ko active Pending
- 2020-12-18 WO PCT/JP2020/047340 patent/WO2021125311A1/ja not_active Ceased
- 2020-12-18 BR BR112022012114A patent/BR112022012114A2/pt unknown
- 2020-12-18 TW TW109145043A patent/TW202136511A/zh unknown
- 2020-12-18 JP JP2021565671A patent/JP7842395B2/ja active Active
- 2020-12-18 CN CN202080097251.XA patent/CN115151642A/zh active Pending
- 2020-12-18 CA CA3165316A patent/CA3165316A1/en active Pending
- 2020-12-18 MX MX2022007491A patent/MX2022007491A/es unknown
-
2022
- 2022-07-15 CO CONC2022/0009983A patent/CO2022009983A2/es unknown
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