JPWO2021087093A5 - - Google Patents
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- Publication number
- JPWO2021087093A5 JPWO2021087093A5 JP2022524112A JP2022524112A JPWO2021087093A5 JP WO2021087093 A5 JPWO2021087093 A5 JP WO2021087093A5 JP 2022524112 A JP2022524112 A JP 2022524112A JP 2022524112 A JP2022524112 A JP 2022524112A JP WO2021087093 A5 JPWO2021087093 A5 JP WO2021087093A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- alkyl
- membered
- group
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962928139P | 2019-10-30 | 2019-10-30 | |
| US62/928,139 | 2019-10-30 | ||
| US202063035272P | 2020-06-05 | 2020-06-05 | |
| US63/035,272 | 2020-06-05 | ||
| US202063047411P | 2020-07-02 | 2020-07-02 | |
| US63/047,411 | 2020-07-02 | ||
| PCT/US2020/057930 WO2021087093A1 (en) | 2019-10-30 | 2020-10-29 | Small molecule degraders of helios and methods of use |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023500611A JP2023500611A (ja) | 2023-01-10 |
| JPWO2021087093A5 true JPWO2021087093A5 (https=) | 2023-10-30 |
| JP2023500611A5 JP2023500611A5 (https=) | 2023-10-30 |
| JP7720833B2 JP7720833B2 (ja) | 2025-08-08 |
Family
ID=75715607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022524112A Active JP7720833B2 (ja) | 2019-10-30 | 2020-10-29 | Ｈｅｌｉｏｓの低分子分解誘導剤および使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230002397A1 (https=) |
| EP (1) | EP4051386A4 (https=) |
| JP (1) | JP7720833B2 (https=) |
| KR (1) | KR20220092920A (https=) |
| CN (1) | CN114650868A (https=) |
| AU (1) | AU2020374957A1 (https=) |
| BR (1) | BR112022007867A2 (https=) |
| CA (1) | CA3154942A1 (https=) |
| CL (1) | CL2022001111A1 (https=) |
| CR (1) | CR20220234A (https=) |
| DO (1) | DOP2022000091A (https=) |
| IL (1) | IL292173A (https=) |
| MX (1) | MX2022005232A (https=) |
| PE (1) | PE20221457A1 (https=) |
| PH (1) | PH12022550980A1 (https=) |
| WO (1) | WO2021087093A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20220234A (es) * | 2019-10-30 | 2022-07-19 | Dana Farber Cancer Inst Inc | Degradadores de moléculas pequeñas de helios y procedimientos de uso |
| AU2020387392B2 (en) | 2019-11-19 | 2025-09-11 | Bristol-Myers Squibb Company | Compounds useful as inhibitors of Helios protein |
| US20230271940A1 (en) * | 2020-08-03 | 2023-08-31 | Novartis Ag | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| IL301690A (en) * | 2020-10-16 | 2023-05-01 | Dana Farber Cancer Inst Inc | Piperidinyl small molecule degraders of helios and methods of use |
| EP4452415B1 (en) | 2021-12-22 | 2026-02-25 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| CN118401512A (zh) * | 2021-12-24 | 2024-07-26 | 苏州开拓药业股份有限公司 | 一种具有酰亚胺骨架的多蛋白降解剂 |
| CN116640122A (zh) * | 2022-02-16 | 2023-08-25 | 苏州国匡医药科技有限公司 | Ikzf2降解剂及包含其的药物组合物和用途 |
| CA3253296A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Zinc Finger Degradation Agents of the Ikaros Family and Their Uses |
| WO2023183540A1 (en) * | 2022-03-25 | 2023-09-28 | Regents Of The University Of Michigan | Ikzf2 degraders and uses thereof |
| WO2023201012A1 (en) * | 2022-04-15 | 2023-10-19 | Regents Of The University Of Michigan | Ikzf2 degraders and uses thereof |
| CN119013270A (zh) * | 2022-04-29 | 2024-11-22 | 西藏海思科制药有限公司 | 一种含氮杂环衍生物及其组合物和药学上的应用 |
| EP4570792A1 (en) * | 2022-08-10 | 2025-06-18 | Gluetacs Therapeutics (Shanghai) Co., Ltd. | Compound based on isoindoline-substituted glutarimide backbone and use thereof |
| WO2024073871A1 (en) * | 2022-10-04 | 2024-04-11 | Biofront Ltd | Gspt1 degraders, compositions comprising the degrader, and methods of using the same |
| JP2025537123A (ja) * | 2022-11-11 | 2025-11-14 | ニカング セラピューティクス， インコーポレイテッド | ユビキチンプロテアソーム経路を介してサイクリン依存性キナーゼ２を分解するための２，５－置換ピリミジン誘導体を含有する二官能性化合物 |
| WO2024109918A1 (zh) * | 2022-11-24 | 2024-05-30 | 西藏海思科制药有限公司 | 一种gspt1降解剂及其在医药上的应用 |
| WO2024222918A1 (zh) * | 2023-04-28 | 2024-10-31 | 中国药科大学 | 一种苯并六元杂环类gspt1蛋白降解剂及其应用 |
| WO2025011624A1 (en) * | 2023-07-11 | 2025-01-16 | Etern Biopharma (Shanghai) Co., Ltd. | Bifunctional compounds for androgen receptor degradation and methods of use |
| CN121532386A (zh) * | 2023-07-28 | 2026-02-13 | 杭州中美华东制药有限公司 | 具有蛋白降解作用的芳胺类化合物 |
| WO2025097092A1 (en) * | 2023-11-02 | 2025-05-08 | Neomorph, Inc. | Substituted 3-(5-(4-hydroxypiperidin-4-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and 3-(2-(4-hydroxypiperidin-4-yl)-5-oxo-5,7-dihydro-6h-pyrrolo[3,4-b]pyridin-6-yl)piperidine-2,6-dione derivatives and uses thereof |
| WO2025245178A1 (en) * | 2024-05-21 | 2025-11-27 | Innovo Therapeutics, Inc. | Pak4, cstf2, or cstf2t protein degraders, pharmaceutical compositions, and therapeutic applications |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012268036B2 (en) * | 2011-06-06 | 2017-04-06 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF STATE OF THE DEPARTMENT OF VETERANS AFFAIRS | Methods of inhibiting muscle atrophy |
| TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| JP7585034B2 (ja) * | 2017-10-18 | 2024-11-18 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
| EP3924055B1 (en) * | 2019-02-15 | 2024-04-03 | Novartis AG | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| CN113490528B (zh) * | 2019-02-15 | 2024-12-03 | 诺华股份有限公司 | 3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| WO2020168172A1 (en) * | 2019-02-15 | 2020-08-20 | Zamboni Chem Solutions Inc. | Conjugate compounds for the degradation of raf |
| CR20220234A (es) * | 2019-10-30 | 2022-07-19 | Dana Farber Cancer Inst Inc | Degradadores de moléculas pequeñas de helios y procedimientos de uso |
| KR20220147109A (ko) * | 2020-02-27 | 2022-11-02 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
| CN115916199A (zh) * | 2020-06-23 | 2023-04-04 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案 |
| IL301690A (en) * | 2020-10-16 | 2023-05-01 | Dana Farber Cancer Inst Inc | Piperidinyl small molecule degraders of helios and methods of use |
| CN117355299A (zh) * | 2021-04-29 | 2024-01-05 | 尼奥莫夫公司 | 取代的2-(2,6-二氧代哌啶-3-基)-5-(1-哌啶-4-基)异吲哚啉-1,3-二酮衍生物及其用途 |
| CA3209633A1 (en) * | 2021-04-29 | 2022-11-03 | Tinghu Zhang | Phthalimido cereblon complex binders and transcription factor degraders and methods of use |
-
2020
- 2020-10-29 CR CR20220234A patent/CR20220234A/es unknown
- 2020-10-29 KR KR1020227017914A patent/KR20220092920A/ko active Pending
- 2020-10-29 EP EP20882103.3A patent/EP4051386A4/en active Pending
- 2020-10-29 PE PE2022000693A patent/PE20221457A1/es unknown
- 2020-10-29 WO PCT/US2020/057930 patent/WO2021087093A1/en not_active Ceased
- 2020-10-29 CN CN202080077672.6A patent/CN114650868A/zh active Pending
- 2020-10-29 BR BR112022007867A patent/BR112022007867A2/pt unknown
- 2020-10-29 PH PH1/2022/550980A patent/PH12022550980A1/en unknown
- 2020-10-29 CA CA3154942A patent/CA3154942A1/en active Pending
- 2020-10-29 US US17/772,384 patent/US20230002397A1/en active Pending
- 2020-10-29 JP JP2022524112A patent/JP7720833B2/ja active Active
- 2020-10-29 AU AU2020374957A patent/AU2020374957A1/en active Pending
- 2020-10-29 MX MX2022005232A patent/MX2022005232A/es unknown
-
2022
- 2022-04-12 IL IL292173A patent/IL292173A/en unknown
- 2022-04-27 DO DO2022000091A patent/DOP2022000091A/es unknown
- 2022-04-29 CL CL2022001111A patent/CL2022001111A1/es unknown