JPWO2022081976A5 - - Google Patents
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- Publication number
- JPWO2022081976A5 JPWO2022081976A5 JP2023520211A JP2023520211A JPWO2022081976A5 JP WO2022081976 A5 JPWO2022081976 A5 JP WO2022081976A5 JP 2023520211 A JP2023520211 A JP 2023520211A JP 2023520211 A JP2023520211 A JP 2023520211A JP WO2022081976 A5 JPWO2022081976 A5 JP WO2022081976A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- cycloalkyl
- aryl
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063092610P | 2020-10-16 | 2020-10-16 | |
| US63/092,610 | 2020-10-16 | ||
| US202163153599P | 2021-02-25 | 2021-02-25 | |
| US63/153,599 | 2021-02-25 | ||
| PCT/US2021/055186 WO2022081976A1 (en) | 2020-10-16 | 2021-10-15 | Piperidinyl small molecule degraders of helios and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023545396A JP2023545396A (ja) | 2023-10-30 |
| JP2023545396A5 JP2023545396A5 (https=) | 2024-10-22 |
| JPWO2022081976A5 true JPWO2022081976A5 (https=) | 2024-10-22 |
Family
ID=81208657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023520211A Pending JP2023545396A (ja) | 2020-10-16 | 2021-10-15 | Ｈｅｌｉｏｓのピペリジニル低分子分解剤および使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20240034723A1 (https=) |
| EP (1) | EP4228651A4 (https=) |
| JP (1) | JP2023545396A (https=) |
| KR (1) | KR20230090318A (https=) |
| AU (1) | AU2021361060A1 (https=) |
| CA (1) | CA3192393A1 (https=) |
| CL (1) | CL2023000655A1 (https=) |
| CR (1) | CR20230143A (https=) |
| DO (1) | DOP2023000072A (https=) |
| IL (1) | IL301690A (https=) |
| MX (1) | MX2023004149A (https=) |
| PE (1) | PE20231190A1 (https=) |
| WO (1) | WO2022081976A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20220234A (es) * | 2019-10-30 | 2022-07-19 | Dana Farber Cancer Inst Inc | Degradadores de moléculas pequeñas de helios y procedimientos de uso |
| AU2021330835B2 (en) | 2020-08-24 | 2023-12-14 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
| TW202344257A (zh) | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| KR20240035820A (ko) | 2021-07-09 | 2024-03-18 | 플렉시움 인코포레이티드 | Ikzf2를 조절하는 아릴 화합물 및 약학 조성물 |
| EP4452415B1 (en) | 2021-12-22 | 2026-02-25 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| CN116640122A (zh) * | 2022-02-16 | 2023-08-25 | 苏州国匡医药科技有限公司 | Ikzf2降解剂及包含其的药物组合物和用途 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| CA3253296A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Zinc Finger Degradation Agents of the Ikaros Family and Their Uses |
| US20240327381A1 (en) * | 2023-02-08 | 2024-10-03 | Celgene Corporation | Compounds and Compositions for Selective Degradation of Engineered Proteins |
| WO2025011624A1 (en) * | 2023-07-11 | 2025-01-16 | Etern Biopharma (Shanghai) Co., Ltd. | Bifunctional compounds for androgen receptor degradation and methods of use |
| WO2025117881A1 (en) * | 2023-12-01 | 2025-06-05 | Casma Therapeutics, Inc. | Compounds and methods for inhibiting autophagy |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025245178A1 (en) * | 2024-05-21 | 2025-11-27 | Innovo Therapeutics, Inc. | Pak4, cstf2, or cstf2t protein degraders, pharmaceutical compositions, and therapeutic applications |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| JP7585034B2 (ja) * | 2017-10-18 | 2024-11-18 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
| US12227488B2 (en) * | 2018-12-03 | 2025-02-18 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of Helios and methods of use |
| KR20210106437A (ko) * | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
| CN113874016A (zh) * | 2019-01-29 | 2021-12-31 | 福宏治疗公司 | 化合物及其用途 |
| CN113490528B (zh) * | 2019-02-15 | 2024-12-03 | 诺华股份有限公司 | 3-(1-氧代-5-(哌啶-4-基)异吲哚啉-2-基)哌啶-2,6-二酮衍生物及其用途 |
| CR20220234A (es) * | 2019-10-30 | 2022-07-19 | Dana Farber Cancer Inst Inc | Degradadores de moléculas pequeñas de helios y procedimientos de uso |
| CA3161455A1 (en) * | 2019-11-13 | 2021-05-20 | Aprinoia Therapeutics Limited | Compounds for degrading tau protein aggregates and uses thereof |
| CA3162523A1 (en) * | 2019-12-23 | 2021-07-01 | Hongfu LU | Protein degradation agent compound preparation method and application |
| KR20220147109A (ko) * | 2020-02-27 | 2022-11-02 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
-
2021
- 2021-10-15 IL IL301690A patent/IL301690A/en unknown
- 2021-10-15 US US18/031,077 patent/US20240034723A1/en active Pending
- 2021-10-15 PE PE2023001130A patent/PE20231190A1/es unknown
- 2021-10-15 EP EP21881175.0A patent/EP4228651A4/en active Pending
- 2021-10-15 WO PCT/US2021/055186 patent/WO2022081976A1/en not_active Ceased
- 2021-10-15 AU AU2021361060A patent/AU2021361060A1/en active Pending
- 2021-10-15 KR KR1020237011252A patent/KR20230090318A/ko active Pending
- 2021-10-15 CA CA3192393A patent/CA3192393A1/en active Pending
- 2021-10-15 JP JP2023520211A patent/JP2023545396A/ja active Pending
- 2021-10-15 MX MX2023004149A patent/MX2023004149A/es unknown
- 2021-10-15 CR CR20230143A patent/CR20230143A/es unknown
-
2023
- 2023-03-08 CL CL2023000655A patent/CL2023000655A1/es unknown
- 2023-04-12 DO DO2023000072A patent/DOP2023000072A/es unknown
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