DOP2023000072A - Degradadores de moléculas pequeñas de piperidinilo de helios y procedimientos de uso - Google Patents
Degradadores de moléculas pequeñas de piperidinilo de helios y procedimientos de usoInfo
- Publication number
- DOP2023000072A DOP2023000072A DO2023000072A DO2023000072A DOP2023000072A DO P2023000072 A DOP2023000072 A DO P2023000072A DO 2023000072 A DO2023000072 A DO 2023000072A DO 2023000072 A DO2023000072 A DO 2023000072A DO P2023000072 A DOP2023000072 A DO P2023000072A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- piperidinyl
- helium
- procedures
- small molecule
- helios
- Prior art date
Links
- -1 HELIUM PIPERIDINYL SMALL MOLECULE Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000001064 degrader Substances 0.000 title 1
- 229910052734 helium Inorganic materials 0.000 title 1
- 239000001307 helium Substances 0.000 title 1
- 101000599037 Homo sapiens Zinc finger protein Helios Proteins 0.000 abstract 4
- 102100037796 Zinc finger protein Helios Human genes 0.000 abstract 4
- 230000015556 catabolic process Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se divulgan compuestos y sales, hidratos, solvatos, profármacos, estereoisómeros o tautómeros farmacéuticamente aceptables de los mismos que pueden provocar la degradación de diversas proteínas, por ejemplo, IKZF2 (Helios). También se divulgan composiciones farmacéuticas que los contienen y procedimientos de preparación y uso de los compuestos para tratar enfermedades y trastornos asociados con Helios y que pueden beneficiarse de la degradación de Helios.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063092610P | 2020-10-16 | 2020-10-16 | |
US202163153599P | 2021-02-25 | 2021-02-25 | |
PCT/US2021/055186 WO2022081976A1 (en) | 2020-10-16 | 2021-10-15 | Piperidinyl small molecule degraders of helios and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2023000072A true DOP2023000072A (es) | 2023-09-29 |
Family
ID=81208657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2023000072A DOP2023000072A (es) | 2020-10-16 | 2023-04-12 | Degradadores de moléculas pequeñas de piperidinilo de helios y procedimientos de uso |
Country Status (13)
Country | Link |
---|---|
US (1) | US20240034723A1 (es) |
EP (1) | EP4228651A1 (es) |
JP (1) | JP2023545396A (es) |
KR (1) | KR20230090318A (es) |
AU (1) | AU2021361060A1 (es) |
CA (1) | CA3192393A1 (es) |
CL (1) | CL2023000655A1 (es) |
CR (1) | CR20230143A (es) |
DO (1) | DOP2023000072A (es) |
IL (1) | IL301690A (es) |
MX (1) | MX2023004149A (es) |
PE (1) | PE20231190A1 (es) |
WO (1) | WO2022081976A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20240035820A (ko) | 2021-07-09 | 2024-03-18 | 플렉시움 인코포레이티드 | Ikzf2를 조절하는 아릴 화합물 및 약학 조성물 |
CN116640122A (zh) * | 2022-02-16 | 2023-08-25 | 苏州国匡医药科技有限公司 | Ikzf2降解剂及包含其的药物组合物和用途 |
TW202346277A (zh) | 2022-03-17 | 2023-12-01 | 美商基利科學股份有限公司 | Ikaros鋅指家族降解劑及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
JP2021501570A (ja) * | 2017-10-18 | 2021-01-21 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
CA3119526A1 (en) * | 2018-12-03 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of helios and methods of use |
-
2021
- 2021-10-15 JP JP2023520211A patent/JP2023545396A/ja active Pending
- 2021-10-15 CR CR20230143A patent/CR20230143A/es unknown
- 2021-10-15 EP EP21881175.0A patent/EP4228651A1/en active Pending
- 2021-10-15 CA CA3192393A patent/CA3192393A1/en active Pending
- 2021-10-15 WO PCT/US2021/055186 patent/WO2022081976A1/en active Application Filing
- 2021-10-15 US US18/031,077 patent/US20240034723A1/en active Pending
- 2021-10-15 IL IL301690A patent/IL301690A/en unknown
- 2021-10-15 MX MX2023004149A patent/MX2023004149A/es unknown
- 2021-10-15 KR KR1020237011252A patent/KR20230090318A/ko unknown
- 2021-10-15 AU AU2021361060A patent/AU2021361060A1/en active Pending
- 2021-10-15 PE PE2023001130A patent/PE20231190A1/es unknown
-
2023
- 2023-03-08 CL CL2023000655A patent/CL2023000655A1/es unknown
- 2023-04-12 DO DO2023000072A patent/DOP2023000072A/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20231190A1 (es) | 2023-08-15 |
WO2022081976A1 (en) | 2022-04-21 |
AU2021361060A1 (en) | 2023-03-30 |
KR20230090318A (ko) | 2023-06-21 |
MX2023004149A (es) | 2023-07-10 |
US20240034723A1 (en) | 2024-02-01 |
IL301690A (en) | 2023-05-01 |
CL2023000655A1 (es) | 2023-08-11 |
EP4228651A1 (en) | 2023-08-23 |
CR20230143A (es) | 2023-07-28 |
CA3192393A1 (en) | 2022-04-21 |
JP2023545396A (ja) | 2023-10-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2022001111A1 (es) | Degradadores de moléculas pequeñas de helios y procedimientos de uso | |
DOP2023000072A (es) | Degradadores de moléculas pequeñas de piperidinilo de helios y procedimientos de uso | |
ECSP19048759A (es) | Modulador del regulador de conductancia de transmembrana de fibrosis quística, composiciones farmacéuticas, y proceso para producir el modulador | |
CO2022002842A2 (es) | Degradadores bifuncionales de brd9 y sus métodos de uso | |
UY38221A (es) | Inhibidores de proteínas ras con g12c mutantes | |
UY38001A (es) | Compuestos que inhiben las proteínas ras mutantes g12c | |
UY37656A (es) | Compuestos que inhiben la proteína mcl-1 | |
AR118707A1 (es) | Inhibidores de la proteasa del vih | |
CL2018002410A1 (es) | Inhibidores de mcl-1 y métodos de uso de los mismos | |
CO2022015638A2 (es) | Compuestos, composiciones farmacéuticas y métodos para la preparación de compuestos y para su uso | |
CO2022001357A2 (es) | Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina | |
DOP2006000193A (es) | Compuestos de isoindol-imida y composiciones que los incluye y metodos para su uso | |
UY29087A1 (es) | Derivados de adamantilo, composiciones farmaceuticas que los contienen, procesos para su preparacion y uso terapeutico | |
ES2139959T3 (es) | Derivados de estilbeno utiles como inhibidores de la ciclooxigenasa-2. | |
UY33500A (es) | Derivados de acil sulfonamida y sus sales farmacéuticamente aceptables para uso en medicina | |
CR20190433A (es) | Compuestos de pirimidinil-pyridiloxi-naftil y métodos para tratar enfermedades y trastornos relacionados con ire1 | |
ECSP088584A (es) | Nuevos derivados de benzimidazol como inhibidores del receptor vanilloide 1 (vrl) | |
AR045155A1 (es) | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos | |
ECSP21026485A (es) | Piridazinonas y sus métodos de uso | |
CL2020001020A1 (es) | Derivados de bencimidazol y sus usos. | |
CO2021010930A2 (es) | Hidroxipiridoxazepinas como activadores de nrf2 | |
CO2022008719A2 (es) | Compuestos para modular la actividad de fxr y usos de los mismos | |
CL2022002386A1 (es) | Compuestos de amino pirimidina fusionados | |
UY38006A (es) | Inhibidores de la quinasa mtor, composiciones farmacéuticas que los contienen, y al uso en terapia de tales compuestos y composiciones | |
ECSP055673A (es) | Derivados de 4-(3,5-dicianofenoxi) pirazol para el uso como moduladores de transcriptasa reversa en el tratamiento del vih |