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第１目標温度又は第２目標温度の少なくとも一方は、ユーザに対して個別化されている
、本明細書で開示した任意の実施形態におけるウェアラブルシステム。
［１］人における異常な生物学的事象を検出するためのウェアラブルシステムであって、
人の皮膚表面に対して接触する第２面と、この第２面とは反対側に位置した第１面と、を有する本体と、
前記皮膚表面と連通する加熱源であって、前記皮膚表面を目標温度に加熱するように構成された加熱源と、
前記第２面上に配置され、前記加熱源と接触している前記皮膚表面の温度を測定するように構成された皮膚温度センサと、
前記第２面上に配置され、前記皮膚表面の血液量を測定するように構成された血液量センサと、
前記加熱源と、前記血液量センサと、前記皮膚温度センサと、前記ウェアラブルシステムの周囲の環境温度を測定するように構成された環境温度センサと、に対して通信可能に結合されたハードウェアプロセッサであって、
前記血液量センサからベースライン血液量信号を受信するように、
前記加熱源に対して加熱信号を出力することにより、前記皮膚表面を前記目標温度に加熱することを含む加熱サイクルを開始するように、
前記皮膚表面が前記目標温度に到達したことに応答して、前記血液量センサから第２血液量信号を受信するように、
前記第２血液量信号を、前記ベースライン血液量信号と比較するように、
前記比較に基づいて、異常な生物学的事象が発生しているかどうかを決定するように、構成されたハードウェアプロセッサと、を含む、ウェアラブルシステム。
［２］前記第２血液量信号は、前記加熱源による加熱サイクルの、前に、最中に、及び後に、前記皮膚表面の前記血液量が繰り返して測定されるような、一組の血液量信号を含む、上記［１］に記載のウェアラブルシステム。
［３］前記第２血液量信号は、前記加熱源による加熱サイクルの、前に、最中に、及び後に、前記皮膚表面の前記血液量が連続的に測定されるような、複数の血液量信号を含む、上記［１］に記載のウェアラブルシステム。
［４］前記ハードウェアプロセッサは、前記目標温度に到達した後に、所定長さの時間が経過した後に、あるいは１つ又は複数の加熱サイクルが終了した後に、前記第２血液量信号を受信するように、さらに構成されている、上記［１］に記載のウェアラブルシステム。
［５］前記比較は、前記ベースライン血液量信号に関しての交流（ＡＣ）と直流（ＤＣ）とのベースライン比率と、前記第２血液量信号に関してのＡＣとＤＣとの第２比率と、を計算することと、前記ベースライン比率を前記第２比率と比較することと、を含む、上記［１］に記載のウェアラブルシステム。
［６］前記環境温度センサは、前記ウェアラブルシステムの前記本体の前記第１面上に配置されている、上記［１］に記載のウェアラブルシステム。
［７］前記ウェアラブルシステムに対して通信可能に結合され、前記環境温度センサを含むリモートコンピューティングデバイスを、さらに含む、上記［１］に記載のウェアラブルシステム。
［８］前記リモートコンピューティングデバイスは、ラップトップ、セルラーデバイス、ワークステーション、サーバ、デスクトップコンピュータ、パーソナルデジタルアシスタント、第２ウェアラブルシステム若しくは第２ウェアラブルデバイス、又はネットブックの１つを含む、上記［７］に記載のウェアラブルシステム。
［９］前記加熱源は、前記本体の前記第２面上に配置されている、上記［１］に記載のウェアラブルシステム。
［１０］前記ハードウェアプロセッサは、
前記皮膚温度センサから及び前記環境温度センサから、ベースライン温度信号を受信するように、
前記ベースライン温度信号に基づいて前記目標温度を決定するように、
前記目標温度が最高温度値未満であるかどうかを決定するように、さらに構成されている、上記［９］に記載のウェアラブルシステム。
［１１］前記ハードウェアプロセッサは、前記加熱源を周期的に動作させることにより、前記目標温度を維持するように、さらに構成されている、上記［１０］に記載のウェアラブルシステム。
［１２］前記第２面上に配置された１つ又は複数の皮膚電気活動センサを、さらに含む、上記［１］に記載のウェアラブルシステム。
［１３］前記１つ又は複数の皮膚電気活動センサは、前記加熱部材から、約０．２５インチ～約４インチ（約６．３５ｍｍ～約１０１．６ｍｍ）の分だけ離間している、上記［１２］に記載のウェアラブルシステム。
［１４］前記ウェアラブルシステムが結合された身体部分の動きを測定するように構成された１つ又は複数のモーションセンサを、さらに含む、上記［１］に記載のウェアラブルシステム。
［１５］前記第１面及び前記第２面は、前記第１面と前記第２面との間に空気流を提供するために、それらの間に空洞を画定している、上記［１］に記載のウェアラブルシステム。
［１６］前記ハードウェアプロセッサは、前記第１面上に又は前記第１面内に位置している、上記［１５］に記載のウェアラブルシステム。
［１７］前記第１面及び前記第２面によって画定された前記空洞は、前記加熱源を、前記第１面上の又は前記第１面内の前記ハードウェアプロセッサから、物理的に離間させている、上記［１６］に記載のウェアラブルシステム。
［１８］前記第１面及び前記第２面によって画定された前記空洞は、加熱サイクル間に前記加熱源の冷却を促進するのに充分な容積を有している、上記［１６］に記載のウェアラブルシステム。
［１９］前記異常な生物学的事象は、脳卒中事象を含む、上記［１］に記載のウェアラブルシステム。
［２０］前記ウェアラブルシステムが、ユーザの左肢上に配置され、第２ウェアラブルシステムが、前記ユーザの右肢上に配置され、前記第２ウェアラブルシステムは、第２加熱部材と、第２皮膚温度センサと、第２血液量センサと、を含み、前記ハードウェアプロセッサは、右側の血液量信号を左側の血液量信号と比較することにより、前記異常な生物学的事象が発生しているかどうかを決定するように、さらに構成されている、上記［１］に記載のウェアラブルシステム。
［２１］前記ハードウェアプロセッサは、
前記左肢及び前記右肢から受信した前記信号どうしを、時間的に同期させるように、
前記左肢及び前記右肢からの前記同期させた前記信号どうしを比較することにより、前記異常な生物学的事象が発生しているかどうかを決定するように、さらに構成されている、上記［２０］に記載のウェアラブルシステム。
［２２］前記比較に際しては、前記左肢と前記右肢との間におけるベースラインの差を考慮する、上記［２１］に記載のウェアラブルシステム。
［２３］前記本体に対して結合された締付可能なバンドを、さらに含む、上記［１］に記載のウェアラブルシステム。
［２４］前記締付可能なバンドは、正確なセンサ読取を可能とするために、前記加熱部材、前記皮膚温度センサ、前記血液量センサ、又はこれらの組合せ、の１つ又は複数が前記皮膚表面に対して充分に結合していることを示す視覚的インジケータを、さらに含む、上記［２３］に記載のウェアラブルシステム。
［２５］前記締付可能なバンドの１つ又は複数の端部は、前記第２面上に配置された１つ又は複数のセンサに対して中心合わせされた位置で、前記本体に対して結合されている、上記［２４］に記載のウェアラブルシステム。
［２６］前記加熱源は、前記血液量センサと前記皮膚温度センサとの一方又は両方において、同心円状に配置されている、上記［１］に記載のウェアラブルシステム。
［２７］前記血液量センサは、光電式脈波センサ又はインピーダンス式脈波センサを含む、上記［１］に記載のウェアラブルシステム。
［２８］前記皮膚温度センサは、熱電対、抵抗温度検出器、サーミスタ、又は赤外線温度センサ、を含む、上記［１］に記載のウェアラブルシステム。
［２９］前記加熱源に対して結合され、前記加熱源を前記第２面に対して結合するように、かつ前記加熱源を前記空洞に対して少なくとも部分的に露出させるように構成された支持構造を、さらに含む、上記［１］に記載のウェアラブルシステム。
［３０］前記血液量センサは、心拍数、心拍数変動、又は酸素飽和度の１つ又は複数を測定するように、さらに構成されている、上記［１］に記載のウェアラブルシステム。
［３１］前記目標温度は、ユーザに対して個別化される、上記［１］に記載のウェアラブルシステム。
［３２］前記目標温度の前記個別化は、前記皮膚表面で感知された温度に関連したユーザ入力を受け取ることを含む、上記［３１］に記載のウェアラブルシステム。
［３３］前記目標温度の前記個別化は、前記血液量センサから受信した信号に基づいている、上記［３１］に記載のウェアラブルシステム。
［３４］前記加熱源は、加熱部材又は環境温度の１つを含む、上記［１］に記載のウェアラブルシステム。
［３５］前記ハードウェアプロセッサは、前記異常な生物学的事象の前記決定に応答して、ホームオートメーションシステムを電子的に管理するように構成された第１電子システムに対して、電子メッセージを送信するように構成されている、上記［１］に記載のウェアラブルシステム。
［３６］前記ホームオートメーションシステムは、ドアロックを含み、前記電子メッセージは、前記第１電子システムに対して、前記ドアロックの解錠を指示するように構成されている、上記［３５］に記載のウェアラブルシステム。
［３７］前記ホームオートメーションシステムは、ホームアラームシステムを含み、前記電子メッセージは、前記第１電子システムに対して、前記ホームアラームシステムを無効とするよう指示するように構成されている、上記［３５］又は［３６］に記載のウェアラブルシステム。
［３８］前記ホームオートメーションシステムは、ディスプレイを含み、前記電子メッセージは、前記第１電子システムに対して、ユーザの医療情報を表示するよう指示するように構成されている、上記［３５］～［３７］のいずれか一項に記載のウェアラブルシステム。
［３９］前記医療情報は、投薬情報及び／又は投薬処方の遵守を含む、上記［３８］に記載のウェアラブルシステム。
［４０］前記ホームオートメーションシステムは、ディスプレイを含み、前記電子メッセージは、前記第１電子システムに対して、脳卒中処置ユーザインターフェースを表示するよう指示するように構成されている、上記［３５］に記載のウェアラブルシステム。
［４１］前記ホームオートメーションシステムは、スピーカシステムを含み、前記電子メッセージは、前記第１電子システムに対して、前記スピーカシステムを使用した可聴アラームを始動させるよう指示するように構成されている、上記［３５］～［４０］のいずれか一項に記載のウェアラブルシステム。
［４２］前記ハードウェアプロセッサは、前記異常な生物学的事象の前記決定に応答して、第三者コンピューティングシステムに対して警告を発出するように、さらに構成されている、上記［１］に記載のウェアラブルシステム。
［４３］前記第三者コンピューティングシステムは、緊急サービスシステムを含む、上記［４２］に記載のウェアラブルシステム。
［４４］前記第三者コンピューティングシステムは、臨床医コンピューティングシステムを含む、上記［４２］に記載のウェアラブルシステム。
［４５］前記ハードウェアプロセッサは、前記異常な生物学的事象の前記検出に応答して処置プロトコルを開始するように、さらに構成されている、上記［１］に記載のウェアラブルシステム。
［４６］ウェアラブル処置システムをさらに含み、前記処置プロトコルは、前記ウェアラブル処置システムを活性化するように構成されている、上記［４５］に記載のウェアラブルシステム。
［４７］前記ウェアラブル処置システムは、超音波ヘルメットを含む、上記［４６］に記載のウェアラブルシステム。
［４８］前記ウェアラブル処置システムは、冷却ガス供給システムを含む、上記［４６］に記載のウェアラブルシステム。
［４９］前記ウェアラブル処置システムは、冷却ヘルメットを含む、上記［４６］に記載のウェアラブルシステム。
［５０］人における異常な生物学的事象を検出するためのウェアラブルシステムであって、
人の皮膚表面に対して接触する第２面と、この第２面とは反対側に位置した第１面と、を有する本体であって、前記第１面及び前記第２面は、前記第１面と前記第２面との間に空気流を提供するために、それらの間に空洞を画定する、本体と、
前記第２面上に配置され、前記皮膚表面を所定時間にわたって加熱するように構成された加熱部材と、
前記第２面上に配置され、前記加熱部材と接触している前記皮膚表面の温度を測定するように構成された皮膚温度センサと、
前記第２面上に配置され、前記皮膚表面の血液量を測定するように構成された血液量センサと、
前記加熱部材と、前記血液量センサと、前記皮膚温度センサと、前記ウェアラブルシステムの周囲の環境温度を測定するように構成された環境温度センサと、に対して通信可能に結合されたハードウェアプロセッサであって、
前記血液量センサからベースライン血液量信号を受信するように、
前記加熱部材に対して加熱信号を出力することにより、前記皮膚表面を目標温度に加熱する加熱サイクルを開始するように、
前記皮膚表面が前記目標温度に到達したことに応答して、前記血液量センサから第２血液量信号を受信するように、
前記第２血液量信号を、前記ベースライン血液量信号と比較するように、
前記比較に基づいて、異常な生物学的事象が発生しているかどうかを決定するように、構成されたハードウェアプロセッサと、を含む、ウェアラブルシステム。
［５１］人における異常な生物学的事象を検出するためのウェアラブルシステムであって、
人の皮膚表面に対して接触する第２面と、この第２面とは反対側に位置した第１面と、を有する本体と、
前記皮膚表面と連通する加熱源であり、前記皮膚表面を目標温度に加熱するように構成された加熱源と、
前記第２面上に配置され、前記加熱源と接触している前記皮膚表面の温度を測定するように構成された皮膚温度センサと、
前記第２面上に配置され、前記人における関心のあるパラメータを測定するように構成されたセンサと、
前記加熱源と、前記センサと、前記皮膚温度センサと、前記ウェアラブルシステムの周囲の環境温度を測定するように構成された環境温度センサと、に対して通信可能に結合されたハードウェアプロセッサであって、
前記センサからベースラインセンサ信号を受信するように、
前記加熱源に対して加熱信号を出力することにより、前記皮膚表面を前記目標温度に加熱する加熱サイクルを開始するように、
前記皮膚表面が前記目標温度に到達したことに応答して、前記センサから第２センサ信号を受信するように、
前記第２センサ信号を、前記ベースラインセンサ信号と比較するように、
前記比較に基づいて、異常な生物学的事象が発生しているかどうかを決定するように、構成されたハードウェアプロセッサと、を含む、ウェアラブルシステム。
［５２］前記センサは、ストレッチセンサ、皮膚電気活動センサ、心電図センサ、カメラ、又は血液量センサからなる群から選択される、上記［５１］に記載のウェアラブルシステム。
［５３］前記関心のあるパラメータは、血圧、心拍数、心拍数変動、視線、顔の表情、皮膚コンダクタンス応答、血管拡張応答、又は拡張応答の１つ又は複数を含む、上記［５１］に記載のウェアラブルシステム。
［５４］人における異常な生物学的事象を検出するためのウェアラブルシステムであって、
人の皮膚表面に対して接触する第２面と、この第２面とは反対側に位置した第１面と、を有する本体と、
前記皮膚表面と連通し、前記皮膚表面に対して刺激を印加するように構成された刺激源と、
前記第２面上に配置され、前記皮膚表面の血液量を測定するように構成された血液量センサと、
前記刺激源と前記血液量センサとに対して通信可能に結合されたハードウェアプロセッサであって、
前記血液量センサからベースライン血液量信号を受信するように、
前記刺激源に対して刺激信号を出力することにより、刺激サイクルを開始するように、
前記刺激サイクルの前記開始に応答して、前記血液量センサから第２血液量信号を受信するように、
前記第２血液量信号を、前記ベースライン血液量信号と比較するように、
前記比較に基づいて、異常な生物学的事象が発生しているかどうかを決定するように、構成されたハードウェアプロセッサと、を含む、ウェアラブルシステム。
［５５］前記刺激源は、加熱源を含む、上記［５４］に記載のウェアラブルシステム。
［５６］前記刺激源は、電源を含む、上記［５４］に記載のウェアラブルシステム。
［５７］前記比較は、血管拡張応答の変化を決定することを含む、上記［５４］に記載のウェアラブルシステム。
［５８］前記刺激源は、ペルチェ冷却器を含む、上記［５４］に記載のウェアラブルシステム。
［５９］前記第２血液量信号は、前記刺激サイクルの、前に、最中に、及び後に、前記皮膚表面の前記血液量が繰り返して測定されるような、一組をなす複数の血液量信号を含む、上記［５４］に記載のウェアラブルシステム。
［６０］前記第２血液量信号は、前記刺激サイクルの、前に、最中に、及び後に、前記皮膚表面の前記血液量が連続的に測定されるような、複数の血液量信号を含む、上記［５４］に記載のウェアラブルシステム。
［６１］前記ハードウェアプロセッサは、目標刺激へと到達した後に、あるいは所定長さの時間が経過した後に、あるいは１つ又は複数の刺激サイクルが終了した後に、前記第２血液量信号を受信するように、さらに構成されている、上記［５４］に記載のウェアラブルシステム。
［６２］前記比較は、前記ベースライン血液量信号に関しての交流（ＡＣ）と直流（ＤＣ）とのベースライン比率と、前記第２血液量信号に関してのＡＣとＤＣとの第２比率と、を計算することと、前記ベースライン比率を前記第２比率と比較することと、を含む、上記［５４］に記載のウェアラブルシステム。
［６３］前記血液量センサは、前記ウェアラブルシステムの前記本体の前記第１面上に配置されている、上記［５４］に記載のウェアラブルシステム。
［６４］前記ウェアラブルシステムに対して通信可能に結合されたリモートコンピューティングデバイスであり、前記血液量センサを含むリモートコンピューティングデバイスを、さらに含む、上記［５４］に記載のウェアラブルシステム。
［６５］前記リモートコンピューティングデバイスは、ラップトップ、セルラーデバイス、ワークステーション、サーバ、デスクトップコンピュータ、パーソナルデジタルアシスタント、第２ウェアラブルシステム若しくは第２ウェアラブルデバイス、又はネットブックの１つを含む、上記［６４］に記載のウェアラブルシステム。
［６６］前記刺激源は、前記本体の前記第２面上に配置されている、上記［５４］に記載のウェアラブルシステム。
［６７］前記ハードウェアプロセッサは、
前記血液量センサからベースライン血液量信号を受信するように、
前記ベースライン血液量信号に基づいて目標血液量を決定するように、
前記目標血液量が最大血液量値未満であるかどうかを決定するように、さらに構成されている、上記［６６］に記載のウェアラブルシステム。
［６８］前記ハードウェアプロセッサは、前記刺激源を周期的に動作させることにより、前記目標血液量を維持するように、さらに構成されている、上記［６７］に記載のウェアラブルシステム。
［６９］前記第２面上に配置された１つ又は複数の皮膚電気活動センサを、さらに含む、上記［５４］に記載のウェアラブルシステム。
［７０］前記１つ又は複数の皮膚電気活動センサは、前記刺激源から、約０．２５インチ～約４インチ（約６．３５ｍｍ～約１０１．６ｍｍ）の分だけ離間している、上記［６９］に記載のウェアラブルシステム。
［７１］前記ウェアラブルシステムが結合された身体部分の移動を測定するように構成された１つ又は複数のモーションセンサを、さらに含む、上記［５４］に記載のウェアラブルシステム。
［７２］前記第１面及び前記第２面は、前記第１面と前記第２面との間に空気流を提供するために、それらの間に空洞を形成している、上記［５４］に記載のウェアラブルシステム。
［７３］前記ハードウェアプロセッサは、前記第１面上に又は前記第１面内に位置している、上記［７２］に記載のウェアラブルシステム。
［７４］前記第１面及び前記第２面によって形成された前記空洞は、前記刺激源を、前記第１面上の又は前記第１面内の前記ハードウェアプロセッサから、物理的に離間させている、上記［７３］に記載のウェアラブルシステム。
［７５］前記第１面及び前記第２面によって形成された前記空洞は、刺激サイクルどうしの間に前記刺激源の冷却を促進するのに充分な容積を有している、上記［７３］に記載のウェアラブルシステム。
［７６］前記異常な生物学的事象は、脳卒中事象を含む、上記［５４］に記載のウェアラブルシステム。
［７７］前記ウェアラブルシステムが、ユーザの左肢上に配置され、第２ウェアラブルシステムが、前記ユーザの右肢上に配置され、前記第２ウェアラブルシステムは、第２刺激源と、第２血液量センサと、を含み、前記ハードウェアプロセッサは、右側の血液量信号を左側の血液量信号と比較することにより、前記生物学的異常事象が発生しているかどうかを決定するように、さらに構成されている、上記［５４］に記載のウェアラブルシステム。
［７８］前記ハードウェアプロセッサは、
前記左肢及び前記右肢から受信した前記信号どうしを、時間的に同期させるように、
前記左肢及び前記右肢からの前記同期させた前記信号どうしを比較することにより、前記異常な生物学的事象が発生しているかどうかを決定するように、さらに構成されている、上記［７７］に記載のウェアラブルシステム。
［７９］前記比較に際しては、前記左肢と前記右肢との間におけるベースラインの差を考慮する、上記［７８］に記載のウェアラブルシステム。
［８０］前記本体に対して結合された締付可能なバンドを、さらに含む、上記［５４］に記載のウェアラブルシステム。
［８１］前記締付可能なバンドは、正確なセンサ読取を可能とするために、前記刺激源、前記血液量センサ、又はこれらの組合せ、の１つ又は複数が前記皮膚表面に対して充分に結合していることを示すための、視覚的インジケータを、さらに含む、上記［８０］に記載のウェアラブルシステム。
［８２］前記締付可能なバンドの１つ又は複数の端部は、前記第２面上に配置された１つ又は複数のセンサに対して中心合わせされた位置で、前記本体に対して結合されている、上記［８１］に記載のウェアラブルシステム。
［８３］前記刺激源は、前記血液量センサにおいて、同心円状に配置されている、上記［５４］に記載のウェアラブルシステム。
［８４］前記血液量センサは、光電式脈波センサ又はインピーダンス式脈波センサを含む、上記［５４］に記載のウェアラブルシステム。
［８５］前記刺激源に対して結合された支持構造であり、前記刺激源を前記第２面に対して結合するように構成され、さらに、前記刺激源を前記空洞に対して少なくとも部分的に露出させるように構成された支持構造を、さらに含む、上記［５４］に記載のウェアラブルシステム。
［８６］前記血液量センサは、心拍数、心拍数変動、又は酸素飽和度、の１つ又は複数を測定するように、さらに構成されている、上記［５４］に記載のウェアラブルシステム。
［８７］前記刺激サイクルは、ユーザに対して個別化される、上記［５４］に記載のウェアラブルシステム。
［８８］前記刺激サイクルの前記個別化は、前記皮膚表面で感知された刺激に関連したユーザ入力を受け取ることを含む、上記［８７］に記載のウェアラブルシステム。
［８９］前記刺激サイクルの前記個別化は、前記血液量センサから受信した信号に基づいている、上記［８７］に記載のウェアラブルシステム。
［９０］前記刺激源は、加熱部材又は環境温度の１つを含む、上記［５４］に記載のウェアラブルシステム。
［９１］前記ハードウェアプロセッサは、前記異常な生物学的事象の前記決定に応答して、ホームオートメーションシステムを電子的に管理するように構成された第１電子システムに対して、電子メッセージを送信するように構成されている、上記［５４］に記載のウェアラブルシステム。
［９２］前記ホームオートメーションシステムは、ドアロックを含み、前記電子メッセージは、前記第１電子システムに対して、前記ドアロックの解錠を指示するように構成されている、上記［９１］に記載のウェアラブルシステム。
［９３］前記ホームオートメーションシステムは、ホームアラームシステムを含み、前記電子メッセージは、前記第１電子システムに対して、前記ホームアラームシステムを無効とするよう指示するように構成されている、上記［９１］又は［９２］に記載のウェアラブルシステム。
［９４］前記ホームオートメーションシステムは、ディスプレイを含み、前記電子メッセージは、前記第１電子システムに対して、ユーザの医療情報を表示するよう指示するように構成されている、上記［９１］～［９３］のいずれか一項に記載のウェアラブルシステム。
［９５］前記医療情報は、投薬情報及び／又は投薬処方の遵守を含む、上記［９４］に記載のウェアラブルシステム。
［９６］前記ホームオートメーションシステムは、ディスプレイを含み、前記電子メッセージは、前記第１電子システムに対して、脳卒中処置ユーザインターフェースを表示するよう指示するように構成されている、上記［９１］に記載のウェアラブルシステム。
［９７］前記ホームオートメーションシステムは、スピーカシステムを含み、前記電子メッセージは、前記第１電子システムに対して、前記スピーカシステムを使用した可聴アラームを始動させるよう指示するように構成されている、上記［９１］～［９６］のいずれか一項に記載のウェアラブルシステム。
［９８］前記ハードウェアプロセッサは、前記異常な生物学的事象の前記決定に応答して、第三者コンピューティングシステムに対して警告を発出するように、さらに構成されている、上記［５４］に記載のウェアラブルシステム。
［９９］前記第三者コンピューティングシステムは、緊急サービスシステムを含む、上記［９８］に記載のウェアラブルシステム。
［１００］前記第三者コンピューティングシステムは、臨床医コンピューティングシステムを含む、上記［９８］に記載のウェアラブルシステム。
［１０１］前記ハードウェアプロセッサは、前記異常な生物学的事象の前記検出に応答して処置プロトコルを開始するように、さらに構成されている、上記［５４］に記載のウェアラブルシステム。
［１０２］ウェアラブル処置システムをさらに含み、前記処置プロトコルは、前記ウェアラブル処置システムを活性化するように構成されている、上記［１０１］に記載のウェアラブルシステム。
［１０３］前記ウェアラブル処置システムは、超音波ヘルメットを含む、上記［１０２］に記載のウェアラブルシステム。
［１０４］前記ウェアラブル処置システムは、冷却ガス供給システムを含む、上記［１０２］に記載のウェアラブルシステム。
［１０５］前記ウェアラブル処置システムは、冷却ヘルメットを含む、上記［１０２］に記載のウェアラブルシステム。
［１０６］人における異常な生物学的事象を検出するためのシステムであって、
前記人の身体の右側上に位置した第１組織部位を第１時間に刺激するように構成された第１刺激源と、
前記人の身体の左側上に位置した第２組織部位を第２時間に刺激するように構成された第２刺激源と、
１つ又は複数のハードウェアプロセッサであって、
前記第１組織部位の前記刺激に基づいて、第１血管拡張応答を決定するように、
前記第２組織部位の前記刺激に基づいて、第２血管拡張応答を決定するように、
前記第１血管拡張応答及び前記第２血管拡張応答に関する１つ又は複数の差を決定するように、
前記第１血管拡張応答及び前記第２血管拡張応答に関して決定された前記１つ又は複数の差に基づいて、異常な生物学的事象を検出するように、構成された１つ又は複数のハードウェアプロセッサと、を含む、システム。
［１０７］前記第１刺激源は、加熱源、冷却源、又は電源、の少なくとも１つ又は複数を含む、上記［１０６］に記載のシステム。
［１０８］前記第２刺激源は、加熱源、冷却源、又は電源、の少なくとも１つ又は複数を含む、上記［１０６］に記載のシステム。
［１０９］前記第１時間は、前記第２時間と同期している、上記［１０６］に記載のシステム。
［１１０］前記第１血管拡張応答は、第１血液量センサからの測定に応答したパラメータに基づいて決定される、上記［１０６］に記載のシステム。
［１１１］前記第２血管拡張応答は、第２血液量センサからの測定に応答したパラメータに基づいて決定される、上記［１０６］に記載のシステム。
［１１２］前記第１血管拡張応答は、電気的活動度センサからの測定に応答したパラメータに基づいて決定される、上記［１０６］に記載のシステム。
［１１３］前記第２血管拡張応答は、電気的活動度センサからの測定に応答したパラメータに基づいて決定される、上記［１０６］に記載のシステム。
［１１４］前記１つ又は複数のハードウェアプロセッサは、前記第１組織部位における前記刺激の前に、第１ベースライン血管拡張応答を決定するように、そして、前記第２組織部位における前記刺激の前に、第２ベースライン血管拡張応答を決定するように、さらに構成されている、上記［１０６］に記載のシステム。
［１１５］人における脳卒中事象を検出するためのウェアラブルシステムであって、
人の第１皮膚表面に対して接触するように構成され、さらに、前記人の左肢に対して固定されるように構成された第１ウェアラブルデバイスであって、
前記第１皮膚表面と連通する第１加熱源であり、前記第１皮膚表面を第１目標温度に加熱するように構成された第１加熱源と、
前記第１皮膚表面の第１温度を測定するように構成された第１皮膚温度センサと、
前記第１皮膚表面に対して近接した第１組織部位における第１血液量を測定するように構成された第１血液量センサと、を含む第１ウェアラブルデバイスと、
前記人の第２皮膚表面に対して接触するように構成され、さらに、前記人の右肢に対して固定されるように構成された、第２ウェアラブルデバイスであって、
前記第２皮膚表面と連通する第２加熱源であり、前記第２皮膚表面を第２目標温度に加熱するように構成された第２加熱源と、
前記第２皮膚表面の第２温度を測定するように構成された第２皮膚温度センサと、
前記第２皮膚表面に対して近接した第２組織部位における第２血液量を測定するように構成された第２血液量センサと、を含む第２ウェアラブルデバイスと、
１つ又は複数のハードウェアプロセッサであって、
前記第１血液量センサから第１ベースライン血液量信号を受信するように、
前記第２血液量センサから第２ベースライン血液量信号を受信するように、
前記第１加熱源に対して第１加熱信号を出力することにより、前記第１皮膚表面を前記第１目標温度に加熱する第１加熱サイクルを開始するように、
前記第１皮膚表面が前記第１目標温度に到達したことに応答して、前記第１血液量センサから第１刺激後血液量信号を受信するように、
前記第２加熱源に対して第２加熱信号を出力することにより、前記第２皮膚表面を前記第２目標温度に加熱する第２加熱サイクルを開始するように、
前記第２皮膚表面が前記第２目標温度に到達したことに応答して、前記第２血液量センサから第２刺激後血液量信号を受信するように、
前記第１ベースライン血液量信号と、前記第２ベースライン血液量信号と、前記第１刺激後血液量信号と、前記第２刺激後血液量信号と、に基づいて、脳卒中事象を決定するように、構成された１つ又は複数のハードウェアプロセッサと、を含む、ウェアラブルシステム。
［１１６］前記第２刺激後血液量信号は、前記第２加熱源による加熱サイクルの、前に、最中に、及び後に、前記第２皮膚表面の前記第２血液量が繰り返して測定されることのために、一組をなす複数の血液量信号を含む、上記［１１５］に記載のウェアラブルシステム。
［１１７］前記第２刺激後血液量信号は、前記第２加熱源による加熱サイクルの、前に、最中に、及び後に、前記第２皮膚表面の前記第２血液量が連続的に測定されることのために、複数の血液量信号を含む、上記［１１５］に記載のウェアラブルシステム。
［１１８］前記１つ又は複数のハードウェアプロセッサは、前記第１ベースライン血液量信号に関しての交流（ＡＣ）と直流（ＤＣ）との第１ベースライン比率と、前記第２血液量信号に関してのＡＣとＤＣとの第２ベースライン比率と、を計算するように、前記第１ベースライン比率を前記第２ベースライン比率と比較するように、さらに構成されている、上記［１１５］に記載のウェアラブルシステム。
［１１９］前記第１ウェアラブルデバイスは、環境温度センサをさらに含む、上記［１１５］に記載のウェアラブルシステム。
［１２０］前記第１ウェアラブルデバイス及び前記第２ウェアラブルデバイスに対して通信可能に結合されたリモートコンピューティングデバイスを、さらに含む、上記［１１５］に記載のウェアラブルシステム。
［１２１］前記リモートコンピューティングデバイスは、ラップトップ、セルラーデバイス、ワークステーション、サーバ、デスクトップコンピュータ、パーソナルデジタルアシスタント、第２ウェアラブルシステム若しくは第２ウェアラブルデバイス、又はネットブックの１つを含む、上記［１２０］に記載のウェアラブルシステム。
［１２２］１つ又は複数の皮膚電気活動センサを、さらに含む、上記［１１５］に記載のウェアラブルシステム。
［１２３］前記１つ又は複数の皮膚電気活動センサは、前記第１加熱源又は前記第２加熱源の少なくとも１つから、約０．２５インチ～約４インチ（約６．３５ｍｍ～約１０１．６ｍｍ）の分だけ離間している、上記［１２２］に記載のウェアラブルシステム。
［１２４］前記第１ウェアラブルデバイス又は前記第２ウェアラブルデバイスの少なくとも一方が結合された身体部分の移動を測定するように構成された１つ又は複数のモーションセンサを、さらに含む、上記［１１５］に記載のウェアラブルシステム。
［１２５］前記本体に対して結合された少なくとも１つの締付可能なバンドを、さらに含む、上記［１１５］に記載のウェアラブルシステム。
［１２６］前記第１加熱源は、第１血液量センサと第１皮膚温度センサとの一方又は両方において、同心円状に配置されている、上記［１１５］に記載のウェアラブルシステム。
［１２７］前記第２加熱源は、第２血液量センサと第２皮膚温度センサとの一方又は両方において、同心円状に配置されている、上記［１１５］に記載のウェアラブルシステム。
［１２８］前記第１血液量センサは、光電式脈波センサ又はインピーダンス式脈波センサを含む、上記［１１５］に記載のウェアラブルシステム。
［１２９］前記第２血液量センサは、光電式脈波センサ又はインピーダンス式脈波センサを含む、上記［１１５］に記載のウェアラブルシステム。
［１３０］前記第１皮膚温度センサは、熱電対、抵抗温度検出器、サーミスタ、又は赤外線温度センサ、を含む、上記［１１５］に記載のウェアラブルシステム。
［１３１］前記第２皮膚温度センサは、熱電対、抵抗温度検出器、サーミスタ、又は赤外線温度センサ、を含む、上記［１１５］に記載のウェアラブルシステム。
［１３２］前記第１血液量センサは、心拍数、心拍数変動、又は酸素飽和度、の１つ又は複数を測定するように、さらに構成されている、上記［１１５］に記載のウェアラブルシステム。
［１３３］前記第２血液量センサは、心拍数、心拍数変動、又は酸素飽和度、の１つ又は複数を測定するように、さらに構成されている、上記［１１５］に記載のウェアラブルシステム。
［１３４］前記第１目標温度又は前記第２目標温度の少なくとも一方は、ユーザに対して個別化される、上記［１１５］に記載のウェアラブルシステム。
［１３５］前記脳卒中事象の前記決定は、健康な個人に対応して格納された基準データに、さらに基づいている、上記［１１５］に記載のウェアラブルシステム。
［１３６］人における脳卒中事象を検出するためのウェアラブルシステムであって、
人の第１皮膚表面に対して接触するように構成され、さらに、前記人の左肢に対して固定されるように構成された第１ウェアラブルデバイスであって、
前記第１皮膚表面と連通する第１刺激源であり、前記第１皮膚表面に対して第１刺激を印加するように構成された第１刺激源と、
前記第１皮膚表面に対して近接した第１組織部位における第１応答を測定するように構成された第１センサと、を含む第１ウェアラブルデバイスと、
前記人の第２皮膚表面に対して接触するように構成され、さらに、前記人の右肢に対して固定されるように構成された第２ウェアラブルデバイスであって、
前記第２皮膚表面と連通する第２刺激源であり、前記第２皮膚表面に対して第２刺激を印加するように構成された第２刺激源と、
前記第２皮膚表面に対して近接した第２組織部位における第２応答を測定するように構成された第２センサと、を含む第２ウェアラブルデバイスと、
１つ又は複数のハードウェアプロセッサであって、
前記第１刺激源に対して第１刺激信号を出力することにより、前記第１刺激の前記印加を第１時間に開始するように、
前記第１刺激の前記印加の後に、前記第１応答を受信するように、
前記第２刺激源に対して第２刺激信号を出力することにより、前記第２刺激の前記印加を第２時間に開始するように、
前記第２刺激の前記印加の後に、前記第２応答を受信するように、
前記第１応答及び前記第２応答に基づいて、脳卒中事象を決定するように、構成された１つ又は複数のハードウェアプロセッサと、を含む、ウェアラブルシステム。
［１３７］人における脳卒中事象を検出するための方法であって、
人の第１皮膚表面に対して接触するように構成されかつ第１刺激源と第１センサとを含む第１ウェアラブルデバイスを、前記人の左肢に対して固定することと、
前記人の第２皮膚表面に対して接触するように構成されかつ第２刺激源と第２センサとを含む第２ウェアラブルデバイスを、前記人の右肢に対して固定することと、
前記第１刺激源に対して第１刺激信号を出力することにより、前記第１刺激の前記印加を第１時間に開始することと、
前記第１刺激の前記印加後に、前記第１センサによって測定された第１応答を受信することと、
前記第２刺激源に対して第２刺激信号を出力することにより、前記第２刺激の前記印加を第２時間に開始することと、
前記第２刺激の前記印加後に、前記第２センサによって測定された第２応答を受信することと、
前記第１応答と前記第２応答とに基づいて、脳卒中事象を決定することと、を含む、方法。
A wearable system in any embodiment disclosed herein, wherein at least one of the first target temperature or the second target temperature is personalized to a user.
[1] A wearable system for detecting abnormal biological events in humans, comprising:
a main body having a second surface in contact with a human skin surface and a first surface located on the opposite side of the second surface;
a heating source in communication with the skin surface and configured to heat the skin surface to a target temperature;
a skin temperature sensor disposed on the second surface and configured to measure the temperature of the skin surface in contact with the heat source;
a blood volume sensor disposed on the second surface and configured to measure blood volume on the skin surface;
a hardware processor communicatively coupled to the heat source, the blood volume sensor, the skin temperature sensor, and an environmental temperature sensor configured to measure an environmental temperature around the wearable system; And,
receiving a baseline blood volume signal from the blood volume sensor;
initiating a heating cycle comprising heating the skin surface to the target temperature by outputting a heating signal to the heating source;
receiving a second blood volume signal from the blood volume sensor in response to the skin surface reaching the target temperature;
comparing the second blood volume signal to the baseline blood volume signal;
a hardware processor configured to determine whether an abnormal biological event is occurring based on the comparison.
[2] The second blood volume signal is a set of blood volumes such that the blood volume at the skin surface is repeatedly measured before, during, and after a heating cycle by the heating source. The wearable system according to [1] above, including a signal.
[3] The second blood volume signal includes a plurality of blood volumes, such that the blood volume on the skin surface is continuously measured before, during, and after a heating cycle by the heating source. The wearable system according to [1] above, including a signal.
[4] The hardware processor is configured to receive the second blood volume signal after a predetermined amount of time has elapsed after the target temperature has been reached, or after one or more heating cycles have completed. The wearable system according to [1] above, further comprising:
[5] The comparison includes a baseline ratio of alternating current (AC) and direct current (DC) with respect to the baseline blood volume signal and a second ratio of AC and DC with respect to the second blood volume signal. The wearable system according to [1] above, including calculating the baseline ratio and comparing the baseline ratio with the second ratio.
[6] The wearable system according to [1] above, wherein the environmental temperature sensor is disposed on the first surface of the main body of the wearable system.
[7] The wearable system according to [1] above, further comprising a remote computing device communicatively coupled to the wearable system and including the environmental temperature sensor.
[8] The remote computing device includes one of the following: a laptop, a cellular device, a workstation, a server, a desktop computer, a personal digital assistant, a second wearable system or device, or a netbook. The wearable system described in ].
[9] The wearable system according to [1] above, wherein the heat source is disposed on the second surface of the main body.
[10] The hardware processor includes:
receiving a baseline temperature signal from the skin temperature sensor and from the environmental temperature sensor;
determining the target temperature based on the baseline temperature signal;
The wearable system according to [9] above, further configured to determine whether the target temperature is less than a maximum temperature value.
[11] The wearable system according to [10], wherein the hardware processor is further configured to maintain the target temperature by periodically operating the heat source.
[12] The wearable system according to [1] above, further including one or more electrodermal activity sensors disposed on the second surface.
[13] The one or more electrodermal activity sensors are spaced apart from the heating member by about 0.25 inches to about 4 inches (about 6.35 mm to about 101.6 mm); 12].
[14] The wearable system according to [1] above, further comprising one or more motion sensors configured to measure movement of a body part to which the wearable system is coupled.
[15] [1] above, wherein the first surface and the second surface define a cavity therebetween to provide airflow between the first surface and the second surface. Wearable system described in.
[16] The wearable system according to [15], wherein the hardware processor is located on or within the first surface.
[17] The cavity defined by the first surface and the second surface physically separates the heating source from the hardware processor on or within the first surface. The wearable system according to [16] above.
[18] The cavity defined by the first surface and the second surface has a volume sufficient to facilitate cooling of the heating source between heating cycles. wearable system.
[19] The wearable system according to [1] above, wherein the abnormal biological event includes a stroke event.
[20] The wearable system is placed on the user's left limb, and the second wearable system is placed on the user's right limb, and the second wearable system includes a second heating member and a second skin temperature. a second blood volume sensor, the hardware processor determining whether the abnormal biological event is occurring by comparing the right blood volume signal to the left blood volume signal. The wearable system according to [1] above, further configured to make a decision.
[21] The hardware processor includes:
The signals received from the left limb and the right limb are temporally synchronized,
[20] further configured to determine whether the abnormal biological event is occurring by comparing the synchronized signals from the left limb and the right limb. The wearable system described in ].
[22] The wearable system according to [21] above, wherein the comparison takes into account a baseline difference between the left limb and the right limb.
[23] The wearable system according to [1] above, further including a tightenable band coupled to the main body.
[24] The tightenable band is configured such that one or more of the heating member, the skin temperature sensor, the blood volume sensor, or a combination thereof is attached to the skin surface to enable accurate sensor readings. The wearable system according to [23] above, further comprising a visual indicator indicating that the wearable system is sufficiently coupled to the wearable system.
[25] One or more ends of the tightenable band are coupled to the body at a location centered relative to one or more sensors disposed on the second surface. The wearable system according to [24] above.
[26] The wearable system according to [1], wherein the heat source is arranged concentrically in one or both of the blood volume sensor and the skin temperature sensor.
[27] The wearable system according to [1] above, wherein the blood volume sensor includes a photoelectric pulse wave sensor or an impedance pulse wave sensor.
[28] The wearable system according to [1] above, wherein the skin temperature sensor includes a thermocouple, a resistance temperature detector, a thermistor, or an infrared temperature sensor.
[29] A support coupled to the heat source and configured to couple the heat source to the second surface and at least partially expose the heat source to the cavity. The wearable system according to [1] above, further comprising a structure.
[30] The wearable system according to [1] above, wherein the blood volume sensor is further configured to measure one or more of heart rate, heart rate variability, or oxygen saturation.
[31] The wearable system according to [1] above, wherein the target temperature is individualized for the user.
[32] The wearable system according to [31], wherein the individualization of the target temperature includes receiving user input related to the temperature sensed at the skin surface.
[33] The wearable system according to [31], wherein the individualization of the target temperature is based on a signal received from the blood volume sensor.
[34] The wearable system according to [1] above, wherein the heat source includes one of a heating member and an ambient temperature.
[35] The hardware processor transmits an electronic message to a first electronic system configured to electronically manage a home automation system in response to the determination of the abnormal biological event. The wearable system according to [1] above, which is configured to.
[36] The home automation system includes a door lock, and the electronic message is configured to instruct the first electronic system to unlock the door lock. wearable system.
[37] The home automation system includes a home alarm system, and the electronic message is configured to instruct the first electronic system to disable the home alarm system. ] or the wearable system according to [36].
[38] The home automation system includes a display, and the electronic message is configured to instruct the first electronic system to display the user's medical information. 37]. The wearable system according to any one of [37].
[39] The wearable system according to [38] above, wherein the medical information includes medication information and/or compliance with a medication prescription.
[40] The home automation system includes a display, and the electronic message is configured to instruct the first electronic system to display a stroke treatment user interface. wearable system.
[41] The home automation system includes a speaker system, and the electronic message is configured to instruct the first electronic system to initiate an audible alarm using the speaker system. The wearable system according to any one of [35] to [40].
[42] The hardware processor is further configured to issue an alert to a third party computing system in response to the determination of the abnormal biological event. Wearable system described in.
[43] The wearable system according to [42] above, wherein the third party computing system includes an emergency service system.
[44] The wearable system according to [42] above, wherein the third party computing system includes a clinician computing system.
[45] The wearable system of [1] above, wherein the hardware processor is further configured to initiate a treatment protocol in response to the detection of the abnormal biological event.
[46] The wearable system according to [45] above, further comprising a wearable treatment system, and wherein the treatment protocol is configured to activate the wearable treatment system.
[47] The wearable system according to [46] above, wherein the wearable treatment system includes an ultrasonic helmet.
[48] The wearable system according to [46] above, wherein the wearable treatment system includes a cooling gas supply system.
[49] The wearable system according to [46] above, wherein the wearable treatment system includes a cooling helmet.
[50] A wearable system for detecting abnormal biological events in humans, comprising:
A main body having a second surface in contact with a human skin surface and a first surface located on the opposite side of the second surface, the first surface and the second surface being a body defining a cavity therebetween to provide airflow between the first side and the second side;
a heating member disposed on the second surface and configured to heat the skin surface for a predetermined period of time;
a skin temperature sensor disposed on the second surface and configured to measure the temperature of the skin surface in contact with the heating member;
a blood volume sensor disposed on the second surface and configured to measure blood volume on the skin surface;
a hardware processor communicatively coupled to the heating member, the blood volume sensor, the skin temperature sensor, and an environmental temperature sensor configured to measure an environmental temperature around the wearable system; And,
receiving a baseline blood volume signal from the blood volume sensor;
starting a heating cycle for heating the skin surface to a target temperature by outputting a heating signal to the heating member;
receiving a second blood volume signal from the blood volume sensor in response to the skin surface reaching the target temperature;
comparing the second blood volume signal to the baseline blood volume signal;
a hardware processor configured to determine whether an abnormal biological event is occurring based on the comparison.
[51] A wearable system for detecting abnormal biological events in humans, comprising:
a main body having a second surface in contact with a human skin surface and a first surface located on the opposite side of the second surface;
a heating source in communication with the skin surface and configured to heat the skin surface to a target temperature;
a skin temperature sensor disposed on the second surface and configured to measure the temperature of the skin surface in contact with the heat source;
a sensor disposed on the second surface and configured to measure a parameter of interest in the person;
a hardware processor communicatively coupled to the heating source, the sensor, the skin temperature sensor, and an environmental temperature sensor configured to measure an environmental temperature around the wearable system; hand,
receiving a baseline sensor signal from the sensor;
starting a heating cycle for heating the skin surface to the target temperature by outputting a heating signal to the heating source;
receiving a second sensor signal from the sensor in response to the skin surface reaching the target temperature;
comparing the second sensor signal with the baseline sensor signal;
a hardware processor configured to determine whether an abnormal biological event is occurring based on the comparison.
[52] The wearable system according to [51] above, wherein the sensor is selected from the group consisting of a stretch sensor, an electrodermal activity sensor, an electrocardiogram sensor, a camera, or a blood volume sensor.
[53] The parameter of interest includes one or more of blood pressure, heart rate, heart rate variability, gaze, facial expression, skin conductance response, vasodilatory response, or diastolic response, as described in [51] above. wearable system.
[54] A wearable system for detecting abnormal biological events in humans, comprising:
a main body having a second surface in contact with a human skin surface and a first surface located on the opposite side of the second surface;
a stimulation source in communication with the skin surface and configured to apply stimulation to the skin surface;
a blood volume sensor disposed on the second surface and configured to measure blood volume on the skin surface;
a hardware processor communicatively coupled to the stimulation source and the blood volume sensor;
receiving a baseline blood volume signal from the blood volume sensor;
initiating a stimulation cycle by outputting a stimulation signal to the stimulation source;
receiving a second blood volume signal from the blood volume sensor in response to the initiation of the stimulation cycle;
comparing the second blood volume signal to the baseline blood volume signal;
a hardware processor configured to determine whether an abnormal biological event is occurring based on the comparison.
[55] The wearable system according to [54] above, wherein the stimulation source includes a heating source.
[56] The wearable system according to [54] above, wherein the stimulation source includes a power source.
[57] The wearable system according to [54] above, wherein the comparison includes determining a change in vasodilator response.
[58] The wearable system according to [54] above, wherein the stimulation source includes a Peltier cooler.
[59] The second blood volume signal includes a set of a plurality of blood volumes, such that the blood volume at the skin surface is repeatedly measured before, during, and after the stimulation cycle. The wearable system according to [54] above, including a signal.
[60] The second blood volume signal includes a plurality of blood volume signals such that the blood volume at the skin surface is successively measured before, during, and after the stimulation cycle. , the wearable system according to [54] above.
[61] The hardware processor receives the second blood volume signal after reaching a target stimulation, or after a predetermined amount of time has elapsed, or after one or more stimulation cycles have ended. The wearable system according to [54] above, further configured as follows.
[62] The comparison includes a baseline ratio of alternating current (AC) to direct current (DC) with respect to the baseline blood volume signal and a second ratio of AC to DC with respect to the second blood volume signal. The wearable system according to [54] above, comprising calculating the baseline ratio and comparing the baseline ratio with the second ratio.
[63] The wearable system according to [54], wherein the blood amount sensor is disposed on the first surface of the main body of the wearable system.
[64] The wearable system according to [54], further comprising a remote computing device communicatively coupled to the wearable system and including the blood volume sensor.
[65] The remote computing device includes one of a laptop, a cellular device, a workstation, a server, a desktop computer, a personal digital assistant, a second wearable system or device, or a netbook. The wearable system described in ].
[66] The wearable system according to [54], wherein the stimulation source is disposed on the second surface of the main body.
[67] The hardware processor:
receiving a baseline blood volume signal from the blood volume sensor;
determining a target blood volume based on the baseline blood volume signal;
The wearable system according to [66] above, further configured to determine whether the target blood volume is less than a maximum blood volume value.
[68] The wearable system according to [67], wherein the hardware processor is further configured to maintain the target blood volume by periodically operating the stimulation source.
[69] The wearable system according to [54], further comprising one or more electrodermal activity sensors disposed on the second surface.
[70] The one or more electrodermal activity sensors are spaced apart from the stimulation source by about 0.25 inches to about 4 inches (about 6.35 mm to about 101.6 mm); 69].
[71] The wearable system of [54] above, further comprising one or more motion sensors configured to measure movement of a body part to which the wearable system is coupled.
[72] The above-mentioned [54], wherein the first surface and the second surface form a cavity therebetween to provide airflow between the first surface and the second surface. Wearable system described in.
[73] The wearable system according to [72], wherein the hardware processor is located on or within the first surface.
[74] The cavity formed by the first surface and the second surface physically separates the stimulation source from the hardware processor on or within the first surface. The wearable system according to [73] above.
[75] The cavity defined by the first surface and the second surface has a volume sufficient to facilitate cooling of the stimulation source between stimulation cycles. The wearable system described.
[76] The wearable system according to [54] above, wherein the abnormal biological event includes a stroke event.
[77] The wearable system is placed on the user's left limb, and the second wearable system is placed on the user's right limb, and the second wearable system includes a second stimulation source and a second blood volume. a sensor, and the hardware processor is further configured to determine whether the biological abnormality event is occurring by comparing a right blood volume signal to a left blood volume signal. The wearable system according to [54] above.
[78] The hardware processor:
The signals received from the left limb and the right limb are temporally synchronized,
[77] further configured to determine whether the abnormal biological event is occurring by comparing the synchronized signals from the left limb and the right limb. The wearable system described in ].
[79] The wearable system according to [78] above, wherein the comparison takes into account a baseline difference between the left limb and the right limb.
[80] The wearable system according to [54], further comprising a tightenable band coupled to the main body.
[81] The tightenable band ensures that one or more of the stimulus source, the blood volume sensor, or a combination thereof is sufficiently held against the skin surface to enable accurate sensor readings. The wearable system according to [80] above, further comprising a visual indicator to indicate that it is coupled.
[82] One or more ends of the tightenable band are coupled to the body at a location centered relative to one or more sensors disposed on the second surface. The wearable system according to [81] above.
[83] The wearable system according to [54], wherein the stimulation sources are arranged concentrically in the blood volume sensor.
[84] The wearable system according to [54], wherein the blood volume sensor includes a photoelectric pulse wave sensor or an impedance pulse wave sensor.
[85] a support structure coupled to the stimulation source, configured to couple the stimulation source to the second surface, and further configured to couple the stimulation source to the cavity at least partially; The wearable system according to [54] above, further comprising a support structure configured to be exposed.
[86] The wearable system according to [54], wherein the blood volume sensor is further configured to measure one or more of heart rate, heart rate variability, or oxygen saturation.
[87] The wearable system according to [54] above, wherein the stimulation cycle is individualized for the user.
[88] The wearable system of [87], wherein the individualization of the stimulation cycle includes receiving user input related to stimulation sensed at the skin surface.
[89] The wearable system according to [87] above, wherein the individualization of the stimulation cycle is based on a signal received from the blood volume sensor.
[90] The wearable system according to [54] above, wherein the stimulus source includes one of a heating member or environmental temperature.
[91] The hardware processor transmits an electronic message to a first electronic system configured to electronically manage a home automation system in response to the determination of the abnormal biological event. The wearable system according to [54] above, which is configured to.
[92] The home automation system according to [91] above, wherein the home automation system includes a door lock, and the electronic message is configured to instruct the first electronic system to unlock the door lock. wearable system.
[93] The home automation system includes a home alarm system, and the electronic message is configured to instruct the first electronic system to disable the home alarm system. ] or the wearable system according to [92].
[94] The home automation system includes a display, and the electronic message is configured to instruct the first electronic system to display the user's medical information. 93]. The wearable system according to any one of [93].
[95] The wearable system according to [94] above, wherein the medical information includes medication information and/or compliance with a medication prescription.
[96] The home automation system according to [91] above, wherein the home automation system includes a display, and the electronic message is configured to instruct the first electronic system to display a stroke treatment user interface. wearable system.
[97] The home automation system includes a speaker system, and the electronic message is configured to instruct the first electronic system to initiate an audible alarm using the speaker system. The wearable system according to any one of [91] to [96].
[98] The hardware processor is further configured to issue an alert to a third party computing system in response to the determination of the abnormal biological event, as described in [54] above. Wearable system described in.
[99] The wearable system according to [98] above, wherein the third party computing system includes an emergency services system.
[100] The wearable system according to [98] above, wherein the third party computing system includes a clinician computing system.
[101] The wearable system of [54] above, wherein the hardware processor is further configured to initiate a treatment protocol in response to the detection of the abnormal biological event.
[102] The wearable system according to [101] above, further comprising a wearable treatment system, wherein the treatment protocol is configured to activate the wearable treatment system.
[103] The wearable system according to [102] above, wherein the wearable treatment system includes an ultrasonic helmet.
[104] The wearable system according to [102] above, wherein the wearable treatment system includes a cooling gas supply system.
[105] The wearable system according to [102] above, wherein the wearable treatment system includes a cooling helmet.
[106] A system for detecting abnormal biological events in humans, comprising:
a first stimulation source configured to stimulate a first tissue site located on the right side of the person's body at a first time;
a second stimulation source configured to stimulate a second tissue site located on the left side of the person's body at a second time;
one or more hardware processors,
determining a first vasodilatory response based on the stimulation of the first tissue site;
determining a second vasodilatory response based on the stimulation of the second tissue site;
determining one or more differences between the first vasodilatory response and the second vasodilatory response;
one or more hardware configured to detect an abnormal biological event based on the one or more differences determined with respect to the first vasodilator response and the second vasodilator response; A system including a processor.
[107] The system according to [106] above, wherein the first stimulation source includes at least one or more of a heating source, a cooling source, or a power source.
[108] The system according to [106] above, wherein the second stimulation source includes at least one or more of a heating source, a cooling source, or a power source.
[109] The system according to [106] above, wherein the first time is synchronized with the second time.
[110] The system according to [106] above, wherein the first vasodilation response is determined based on a parameter in response to a measurement from a first blood volume sensor.
[111] The system according to [106] above, wherein the second vasodilation response is determined based on a parameter in response to a measurement from a second blood volume sensor.
[112] The system according to [106] above, wherein the first vasodilation response is determined based on a parameter in response to a measurement from an electrical activity sensor.
[113] The system according to [106] above, wherein the second vasodilation response is determined based on a parameter in response to a measurement from an electrical activity sensor.
[114] The one or more hardware processors are configured to determine a first baseline vasodilatory response prior to the stimulation at the first tissue site; The system of [106] above, further configured to determine a second baseline vasodilatory response beforehand.
[115] A wearable system for detecting stroke events in humans, comprising:
A first wearable device configured to contact a first skin surface of a person and further configured to be secured to a left limb of the person, the first wearable device comprising:
a first heat source in communication with the first skin surface and configured to heat the first skin surface to a first target temperature;
a first skin temperature sensor configured to measure a first temperature of the first skin surface;
a first wearable device comprising: a first blood volume sensor configured to measure a first blood volume at a first tissue site proximate to the first skin surface;
A second wearable device configured to contact a second skin surface of the person and further configured to be secured to a right limb of the person, the second wearable device comprising:
a second heat source in communication with the second skin surface and configured to heat the second skin surface to a second target temperature;
a second skin temperature sensor configured to measure a second temperature of the second skin surface;
a second blood volume sensor configured to measure a second blood volume at a second tissue site proximate to the second skin surface;
one or more hardware processors,
receiving a first baseline blood volume signal from the first blood volume sensor;
receiving a second baseline blood volume signal from the second blood volume sensor;
starting a first heating cycle of heating the first skin surface to the first target temperature by outputting a first heating signal to the first heating source;
receiving a first post-stimulus blood volume signal from the first blood volume sensor in response to the first skin surface reaching the first target temperature;
starting a second heating cycle for heating the second skin surface to the second target temperature by outputting a second heating signal to the second heat source;
receiving a second post-stimulus blood volume signal from the second blood volume sensor in response to the second skin surface reaching the second target temperature;
determining a stroke event based on the first baseline blood volume signal, the second baseline blood volume signal, the first post-stimulus blood volume signal, and the second post-stimulus blood volume signal; and one or more hardware processors configured with.
[116] The second post-stimulation blood volume signal is obtained by repeatedly measuring the second blood volume on the second skin surface before, during, and after the heating cycle by the second heat source. In particular, the wearable system according to [115] above, comprising a set of a plurality of blood volume signals.
[117] The second post-stimulation blood volume signal is obtained by continuously measuring the second blood volume on the second skin surface before, during, and after a heating cycle by the second heat source. The wearable system according to [115] above, which includes a plurality of blood volume signals for the purpose of determining the blood volume.
[118] The one or more hardware processors are configured to determine a first baseline ratio of alternating current (AC) to direct current (DC) with respect to the first baseline blood volume signal and with respect to the second blood volume signal. [115], further configured to compare the first baseline ratio with the second baseline ratio to calculate a second baseline ratio between AC and DC. wearable system.
[119] The wearable system according to [115], wherein the first wearable device further includes an environmental temperature sensor.
[120] The wearable system according to [115], further comprising a remote computing device communicatively coupled to the first wearable device and the second wearable device.
[121] The remote computing device includes one of a laptop, a cellular device, a workstation, a server, a desktop computer, a personal digital assistant, a second wearable system or device, or a netbook. The wearable system described in ].
[122] The wearable system according to [115] above, further comprising one or more electrodermal activity sensors.
[123] The one or more electrodermal activity sensors are about 0.25 inches to about 4 inches (about 6.35 mm to about 101 mm) from at least one of the first heating source or the second heating source. 6 mm), the wearable system according to [122] above.
[124] The method of [115] above, wherein at least one of the first wearable device or the second wearable device further comprises one or more motion sensors configured to measure movement of a coupled body part. The wearable system described.
[125] The wearable system according to [115] above, further comprising at least one tightenable band coupled to the main body.
[126] The wearable system according to [115], wherein the first heat source is arranged concentrically in one or both of the first blood volume sensor and the first skin temperature sensor.
[127] The wearable system according to [115], wherein the second heat source is arranged concentrically in one or both of the second blood volume sensor and the second skin temperature sensor.
[128] The wearable system according to [115], wherein the first blood volume sensor includes a photoelectric pulse wave sensor or an impedance pulse wave sensor.
[129] The wearable system according to [115], wherein the second blood volume sensor includes a photoelectric pulse wave sensor or an impedance pulse wave sensor.
[130] The wearable system according to [115], wherein the first skin temperature sensor includes a thermocouple, a resistance temperature detector, a thermistor, or an infrared temperature sensor.
[131] The wearable system according to [115], wherein the second skin temperature sensor includes a thermocouple, a resistance temperature detector, a thermistor, or an infrared temperature sensor.
[132] The wearable system according to [115], wherein the first blood volume sensor is further configured to measure one or more of heart rate, heart rate variability, or oxygen saturation.
[133] The wearable system according to [115], wherein the second blood volume sensor is further configured to measure one or more of heart rate, heart rate variability, or oxygen saturation.
[134] The wearable system according to [115] above, wherein at least one of the first target temperature or the second target temperature is individualized for the user.
[135] The wearable system of [115] above, wherein the determination of the stroke event is further based on reference data stored corresponding to a healthy individual.
[136] A wearable system for detecting stroke events in humans, comprising:
A first wearable device configured to contact a first skin surface of a person and further configured to be secured to a left limb of the person, the first wearable device comprising:
a first stimulation source in communication with the first skin surface and configured to apply a first stimulation to the first skin surface;
a first sensor configured to measure a first response at a first tissue site proximate to the first skin surface;
A second wearable device configured to contact a second skin surface of the person and further configured to be secured to a right limb of the person, the second wearable device comprising:
a second stimulation source in communication with the second skin surface and configured to apply a second stimulation to the second skin surface;
a second sensor configured to measure a second response at a second tissue site proximate to the second skin surface;
one or more hardware processors,
starting the application of the first stimulation at a first time by outputting a first stimulation signal to the first stimulation source;
receiving the first response after the application of the first stimulus;
starting the application of the second stimulation at a second time by outputting a second stimulation signal to the second stimulation source;
receiving the second response after the application of the second stimulus;
one or more hardware processors configured to determine a stroke event based on the first response and the second response.
[137] A method for detecting a stroke event in a person, comprising:
securing a first wearable device to a left leg of the person configured to contact a first skin surface of the person and including a first stimulation source and a first sensor;
securing a second wearable device to the person's right leg, the second wearable device being configured to contact a second skin surface of the person and including a second stimulation source and a second sensor;
starting the application of the first stimulation at a first time by outputting a first stimulation signal to the first stimulation source;
receiving a first response measured by the first sensor after the application of the first stimulus;
starting the application of the second stimulation at a second time by outputting a second stimulation signal to the second stimulation source;
receiving a second response measured by the second sensor after the application of the second stimulus;
determining a stroke event based on the first response and the second response.
Claims (20)
人の皮膚表面に対して接触する第２面と、この第２面とは反対側に位置した第１面と、を有する本体と、
前記皮膚表面と連通する加熱源であり、前記皮膚表面を目標温度に加熱するように構成された加熱源と、
前記第２面上に配置され、前記加熱源と接触している前記皮膚表面の温度を測定するように構成された皮膚温度センサと、
前記第２面上に配置され、前記人における関心のあるパラメータを測定するように構成されたセンサと、
前記加熱源と、前記センサと、前記皮膚温度センサと、前記ウェアラブルシステムの周囲の環境温度を測定するように構成された環境温度センサと、に対して通信可能に結合されたハードウェアプロセッサであって、
前記センサからベースラインセンサ信号を受信するように、
前記加熱源に対して加熱信号を出力することにより、前記皮膚表面を前記目標温度に加熱する加熱サイクルを開始するように、
前記皮膚表面が前記目標温度に到達したことに応答して、前記センサから第２センサ信号を受信するように、
前記第２センサ信号を、前記ベースラインセンサ信号と比較するように、
前記比較に基づいて、異常な生物学的事象が発生しているかどうかを決定するように、構成されたハードウェアプロセッサと、を含む、ウェアラブルシステム。 A wearable system for detecting abnormal biological events in humans, comprising:
a main body having a second surface in contact with a human skin surface and a first surface located on the opposite side of the second surface;
a heating source in communication with the skin surface and configured to heat the skin surface to a target temperature;
a skin temperature sensor disposed on the second surface and configured to measure the temperature of the skin surface in contact with the heat source;
a sensor disposed on the second surface and configured to measure a parameter of interest in the person;
a hardware processor communicatively coupled to the heating source, the sensor, the skin temperature sensor, and an environmental temperature sensor configured to measure an environmental temperature surrounding the wearable system; hand,
receiving a baseline sensor signal from the sensor;
starting a heating cycle for heating the skin surface to the target temperature by outputting a heating signal to the heating source;
receiving a second sensor signal from the sensor in response to the skin surface reaching the target temperature;
comparing the second sensor signal with the baseline sensor signal;
a hardware processor configured to determine whether an abnormal biological event is occurring based on the comparison.
人の皮膚表面に対して接触する第２面と、この第２面とは反対側に位置した第１面と、を有する本体と、
前記皮膚表面と連通し、前記皮膚表面に対して刺激を印加するように構成された刺激源と、
前記第２面上に配置され、前記皮膚表面の血液量を測定するように構成された血液量センサと、
前記刺激源と前記血液量センサとに対して通信可能に結合されたハードウェアプロセッサであって、
前記血液量センサからベースライン血液量信号を受信するように、
前記刺激源に対して刺激信号を出力することにより、刺激サイクルを開始するように、
前記刺激サイクルの前記開始に応答して、前記血液量センサから第２血液量信号を受信するように、
前記第２血液量信号を、前記ベースライン血液量信号と比較するように、
前記比較に基づいて、異常な生物学的事象が発生しているかどうかを決定するように、構成されたハードウェアプロセッサと、を含む、ウェアラブルシステム。 A wearable system for detecting abnormal biological events in humans, comprising:
a main body having a second surface in contact with a human skin surface and a first surface located on the opposite side of the second surface;
a stimulation source in communication with the skin surface and configured to apply stimulation to the skin surface;
a blood volume sensor disposed on the second surface and configured to measure blood volume on the skin surface;
a hardware processor communicatively coupled to the stimulation source and the blood volume sensor;
receiving a baseline blood volume signal from the blood volume sensor;
initiating a stimulation cycle by outputting a stimulation signal to the stimulation source;
receiving a second blood volume signal from the blood volume sensor in response to the initiation of the stimulation cycle;
comparing the second blood volume signal to the baseline blood volume signal;
a hardware processor configured to determine whether an abnormal biological event is occurring based on the comparison.
人の皮膚表面に接触するように構成され、外周を含む第１面と、a first surface configured to contact a human skin surface and including an outer periphery;
前記第１面の切り欠きであって、内周を含む形状を備え、前記外周内に完全に囲まれた切り欠きと、a notch in the first surface, the notch having a shape including an inner periphery and completely surrounded by the outer periphery;
前記皮膚表面と熱的に連通する熱刺激源であって、前記内周と前記外周との間の前記第１面上に形成された部分に延在する表面領域を備える熱刺激源と、a thermal stimulation source in thermal communication with the skin surface, the thermal stimulation source comprising a surface region extending over a portion formed on the first surface between the inner periphery and the outer periphery;
前記皮膚表面の温度を測定するように構成され、前記切り込み内に配置された皮膚温度センサと、a skin temperature sensor configured to measure the temperature of the skin surface and disposed within the incision;
を備える、デバイス。A device comprising:
人の第１皮膚表面を監視するように構成され、前記人の左側を追跡するように構成された第１デバイスであって、A first device configured to monitor a first skin surface of a person and configured to track a left side of the person, the first device comprising:
前記第１皮膚表面と熱的に連通する第１熱刺激源であって、前記第１デバイスの第１本体表面上に延びる第１表面領域を含み、前記第１本体表面が、前記第１皮膚表面に接触するように構成される、第１熱刺激源と、a first thermal stimulus source in thermal communication with the first skin surface, the first surface region extending on a first body surface of the first device, the first body surface being in thermal communication with the first skin surface; a first thermal stimulation source configured to contact the surface;
前記第１皮膚表面の第１温度を測定するように構成され、前記第１表面領域によって囲まれた第１開口内に配置された第１皮膚温度センサと、を備える第１デバイスと、a first skin temperature sensor configured to measure a first temperature of the first skin surface and disposed within a first opening surrounded by the first surface area;
前記人の第２皮膚表面を監視するように構成され、前記人の右側を追跡するように構成された第２デバイスであって、a second device configured to monitor a second skin surface of the person and configured to track a right side of the person;
前記第２皮膚表面と熱的に連通する第２熱刺激源であって、前記第２デバイスの第２本体表面上に延びる第２表面領域を含み、前記第２本体表面が、前記第２皮膚表面に接触するように構成される、第２熱刺激源と、a second thermal stimulation source in thermal communication with the second skin surface, the second surface region extending on a second body surface of the second device, the second body surface being in thermal communication with the second skin surface; a second thermal stimulus source configured to contact the surface;
前記第２皮膚表面の第２温度を測定するように構成され、前記第２表面領域によって囲まれた第２開口内に配置された第２皮膚温度センサと、を備える第２デバイスと、a second skin temperature sensor configured to measure a second temperature of the second skin surface and disposed within a second opening surrounded by the second surface area;
前記第１および第２デバイスに通信可能に結合され、communicatively coupled to the first and second devices;
前記第１皮膚温度センサから第１ベースライン温度信号を受信するように、receiving a first baseline temperature signal from the first skin temperature sensor;
前記第２皮膚温度センサから第２ベースライン温度信号を受信するように、receiving a second baseline temperature signal from the second skin temperature sensor;
前記第１熱刺激源に第１熱刺激信号を出力して、第１期間の第１時間に第１サイクルを開始するように、outputting a first thermal stimulation signal to the first thermal stimulation source to start a first cycle at a first time of a first period;
前記第１熱刺激信号に応答する前記第１皮膚表面の第１温度応答を受信し、前記第１温度応答が、前記第１皮膚温度センサによって測定されるように、receiving a first temperature response of the first skin surface in response to the first thermal stimulation signal, the first temperature response being measured by the first skin temperature sensor;
前記第２熱刺激源に第２熱刺激信号を出力して、第２期間の第２時間に第２サイクルを開始するように、ここで、前記第１時間は前記第２時間と同期している、outputting a second thermal stimulation signal to the second thermal stimulation source to initiate a second cycle at a second time of a second period, wherein the first time is synchronized with the second time; There is,
前記第２熱刺激信号に応答する前記第２皮膚表面の第２温度応答を受信し、前記第２温度応答が、前記第２皮膚温度センサによって測定されるように、receiving a second temperature response of the second skin surface in response to the second thermal stimulation signal, the second temperature response being measured by the second skin temperature sensor;
前記第１温度応答と前記第２温度応答とを比較して、前記第１温度応答と前記第２温度応答との間の差が、前記人の左側と前記人の右側との間の温度非対称性を示しているかどうかを判定するように、かつComparing the first temperature response and the second temperature response, the difference between the first temperature response and the second temperature response indicates a temperature asymmetry between the left side of the person and the right side of the person. and
決定された前記温度非対称の表示に基づいて、脳卒中事象を示す警告を生成するように、構成された１以上のハードウェアプロセッサと、を備える、システム。one or more hardware processors configured to generate an alert indicative of a stroke event based on the determined indication of temperature asymmetry.
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- 2020-10-14 EP EP20877443.0A patent/EP4044906A4/en active Pending
- 2020-10-14 CN CN202080009705.3A patent/CN113347916A/en active Pending
- 2020-10-14 US US17/070,832 patent/US11134859B2/en active Active
- 2020-10-14 WO PCT/US2020/055604 patent/WO2021076642A1/en unknown
- 2020-10-14 AU AU2020366348A patent/AU2020366348A1/en active Pending
- 2020-10-14 JP JP2022522792A patent/JP2022551988A/en active Pending
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2021
- 2021-08-20 US US17/407,852 patent/US11504020B2/en active Active
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2022
- 2022-08-08 US US17/818,281 patent/US20230072213A1/en active Pending
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