JPWO2021075423A1 - - Google Patents
Info
- Publication number
- JPWO2021075423A1 JPWO2021075423A1 JP2021552393A JP2021552393A JPWO2021075423A1 JP WO2021075423 A1 JPWO2021075423 A1 JP WO2021075423A1 JP 2021552393 A JP2021552393 A JP 2021552393A JP 2021552393 A JP2021552393 A JP 2021552393A JP WO2021075423 A1 JPWO2021075423 A1 JP WO2021075423A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019190698 | 2019-10-18 | ||
| JP2019190698 | 2019-10-18 | ||
| PCT/JP2020/038612 WO2021075423A1 (ja) | 2019-10-18 | 2020-10-13 | ホスホロアミダイト活性化剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021075423A1 true JPWO2021075423A1 (https=) | 2021-04-22 |
| JP7452549B2 JP7452549B2 (ja) | 2024-03-19 |
Family
ID=75538471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021552393A Active JP7452549B2 (ja) | 2019-10-18 | 2020-10-13 | ホスホロアミダイト活性化剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12202848B2 (https=) |
| EP (1) | EP4047004B1 (https=) |
| JP (1) | JP7452549B2 (https=) |
| KR (1) | KR102834624B1 (https=) |
| CN (1) | CN114555617B (https=) |
| WO (1) | WO2021075423A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116413359B (zh) * | 2023-03-08 | 2025-09-16 | 杭州诺泰诺和生物医药科技有限公司 | 一种亚磷酰胺单体液相色谱快速分析方法 |
| CN117233281B (zh) * | 2023-09-14 | 2024-11-05 | 上海奥锐特生物科技有限公司 | 2-氰乙基-n,n,n’,n’-四异丙基亚磷酰二胺的检测方法 |
| CN117233282B (zh) * | 2023-09-14 | 2024-12-20 | 上海奥锐特生物科技有限公司 | 2-氰乙基-n,n,n’,n’-四异丙基亚磷酰二胺的检测方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007531794A (ja) * | 2004-04-05 | 2007-11-08 | アルニラム ファーマスーティカルズ インコーポレイテッド | オリゴヌクレオチドの合成および精製に使用する方法および反応試薬 |
| JP2008530092A (ja) * | 2005-02-08 | 2008-08-07 | ハネウェル・インターナショナル・インコーポレーテッド | オリゴヌクレオチド合成のためのホスホルアミダイト活性化剤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5218088A (en) * | 1989-11-02 | 1993-06-08 | Purdue Research Foundation | Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates |
| AU2003269239A1 (en) * | 2002-10-15 | 2004-05-04 | Avecia Biotechnology Inc. | Phosphitylation process |
| JPWO2004052908A1 (ja) | 2002-12-09 | 2006-04-13 | 三井化学株式会社 | フォスフォロアミダイトの製造方法 |
| ES2386709T3 (es) * | 2004-08-26 | 2012-08-27 | Nippon Shinyaku Co., Ltd. | Compuesto de fosforamidita y método para producir un oligo-ARN |
| IL185439A0 (en) * | 2005-03-04 | 2008-01-06 | Girindus Ag | Synthesis of oligonucleotides |
| WO2006116476A1 (en) * | 2005-04-27 | 2006-11-02 | Sigma-Aldrich Co. | Activators for oligonucleotide and phosphoramidite synthesis |
| JPWO2007097447A1 (ja) * | 2006-02-27 | 2009-07-16 | 日本新薬株式会社 | 核酸保護基の脱離方法 |
| CA2671873C (en) * | 2006-12-12 | 2018-10-09 | Brian Stephen Sproat | Oligonucleotides containing high concentrations of guanine monomers |
| US7723528B2 (en) * | 2008-06-05 | 2010-05-25 | Am Chemicals Llc | Sulfur transfer reagents for oligonucleotide synthesis |
| EP2750768B1 (en) * | 2011-08-30 | 2018-10-03 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| NO2718257T3 (https=) * | 2014-05-30 | 2018-04-14 | ||
| AU2016287585B2 (en) * | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
| CN109311925B (zh) * | 2016-05-12 | 2022-06-03 | 罗氏创新中心哥本哈根有限公司 | 立体限定的氧杂氮杂磷杂环戊烷亚磷酰胺单体与核苷或寡核苷酸的增强的偶联 |
-
2020
- 2020-10-13 EP EP20877708.6A patent/EP4047004B1/en active Active
- 2020-10-13 US US17/768,354 patent/US12202848B2/en active Active
- 2020-10-13 WO PCT/JP2020/038612 patent/WO2021075423A1/ja not_active Ceased
- 2020-10-13 JP JP2021552393A patent/JP7452549B2/ja active Active
- 2020-10-13 CN CN202080072331.XA patent/CN114555617B/zh active Active
- 2020-10-13 KR KR1020227012543A patent/KR102834624B1/ko active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007531794A (ja) * | 2004-04-05 | 2007-11-08 | アルニラム ファーマスーティカルズ インコーポレイテッド | オリゴヌクレオチドの合成および精製に使用する方法および反応試薬 |
| JP2008530092A (ja) * | 2005-02-08 | 2008-08-07 | ハネウェル・インターナショナル・インコーポレーテッド | オリゴヌクレオチド合成のためのホスホルアミダイト活性化剤 |
Non-Patent Citations (2)
| Title |
|---|
| J. AM. CHEM. SOC., vol. 113(10), JPN6020049317, 1991, pages 3972 - 3980, ISSN: 0005255292 * |
| ORG. PROC. RES. DEV. ,, vol. 4(3), JPN7020004118, 2000, pages 175 - 181, ISSN: 0005255293 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4047004B1 (en) | 2024-03-06 |
| US20240166674A1 (en) | 2024-05-23 |
| CN114555617B (zh) | 2024-03-08 |
| KR20220083704A (ko) | 2022-06-20 |
| CN114555617A (zh) | 2022-05-27 |
| EP4047004A1 (en) | 2022-08-24 |
| WO2021075423A1 (ja) | 2021-04-22 |
| US12202848B2 (en) | 2025-01-21 |
| EP4047004A4 (en) | 2023-06-14 |
| JP7452549B2 (ja) | 2024-03-19 |
| KR102834624B1 (ko) | 2025-07-15 |
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