JPWO2021066062A5 - - Google Patents
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- Publication number
- JPWO2021066062A5 JPWO2021066062A5 JP2021551413A JP2021551413A JPWO2021066062A5 JP WO2021066062 A5 JPWO2021066062 A5 JP WO2021066062A5 JP 2021551413 A JP2021551413 A JP 2021551413A JP 2021551413 A JP2021551413 A JP 2021551413A JP WO2021066062 A5 JPWO2021066062 A5 JP WO2021066062A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- substituent
- alkylene
- expression inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 17
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 17
- 125000004432 carbon atom Chemical group C* 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 11
- 239000003112 inhibitor Substances 0.000 claims 10
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 claims 6
- 102100039418 Plasminogen activator inhibitor 1 Human genes 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 2
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 2
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 2
- 210000005008 immunosuppressive cell Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 claims 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
- 125000005571 adamantylene group Chemical group 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 238000003782 apoptosis assay Methods 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 229940047091 other immunostimulants in atc Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005522 programmed cell death Effects 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019181014 | 2019-09-30 | ||
| JP2019181014 | 2019-09-30 | ||
| PCT/JP2020/037285 WO2021066062A1 (ja) | 2019-09-30 | 2020-09-30 | 免疫チェックポイント分子の発現抑制剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021066062A1 JPWO2021066062A1 (https=) | 2021-04-08 |
| JPWO2021066062A5 true JPWO2021066062A5 (https=) | 2023-06-28 |
| JP7420402B2 JP7420402B2 (ja) | 2024-01-23 |
Family
ID=75338116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021551413A Active JP7420402B2 (ja) | 2019-09-30 | 2020-09-30 | 免疫チェックポイント分子の発現抑制剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220340665A1 (https=) |
| EP (1) | EP4039276A4 (https=) |
| JP (1) | JP7420402B2 (https=) |
| WO (1) | WO2021066062A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230355605A1 (en) * | 2020-05-20 | 2023-11-09 | Renascience Inc. | Drug for enhancing fibrinolytic system, and use therefor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006507297A (ja) | 2002-05-13 | 2006-03-02 | チルドレンズ・ホスピタル・ロサンジェルス | ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防 |
| US7951806B2 (en) | 2007-07-25 | 2011-05-31 | Renascience Co., Ltd. | Plasminogen activator inhibitor-1 inhibitor |
| WO2009033095A2 (en) * | 2007-09-07 | 2009-03-12 | Cisthera, Incorporated | Humanized pai-1 antibodies |
| EP2272822A4 (en) | 2008-03-31 | 2012-01-18 | Renascience Co Ltd | PLASMINOG ACTIVATOR-1 HEMMER |
| EP2415755A4 (en) | 2009-03-31 | 2012-09-19 | Renascience Co Ltd | INHIBITOR AGENT OF PLASMINOGEN ACTIVATOR INHIBITOR 1 |
| JP5840324B2 (ja) * | 2013-04-15 | 2016-01-06 | 株式会社レナサイエンス | Ｐａｉ−１阻害剤の新規用途 |
| HK1221725A1 (zh) | 2013-08-13 | 2017-06-09 | Sanofi | 纤溶酶原激活剂抑制剂-1(pai-1)的抗体及其用途 |
| JP2015147744A (ja) | 2014-02-06 | 2015-08-20 | 国立大学法人浜松医科大学 | Ｐａｉ−１阻害剤 |
| PL3109320T3 (pl) | 2014-02-21 | 2019-08-30 | Astellas Pharma Inc. | Nowe przeciwciało anty-ludzki PAI-1 |
| JP2020088416A (ja) | 2018-11-15 | 2020-06-04 | シャープ株式会社 | 電子機器および制御装置 |
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2020
- 2020-09-30 JP JP2021551413A patent/JP7420402B2/ja active Active
- 2020-09-30 US US17/764,312 patent/US20220340665A1/en active Pending
- 2020-09-30 EP EP20873304.8A patent/EP4039276A4/en active Pending
- 2020-09-30 WO PCT/JP2020/037285 patent/WO2021066062A1/ja not_active Ceased