JP7420402B2 - 免疫チェックポイント分子の発現抑制剤 - Google Patents

免疫チェックポイント分子の発現抑制剤 Download PDF

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JP7420402B2
JP7420402B2 JP2021551413A JP2021551413A JP7420402B2 JP 7420402 B2 JP7420402 B2 JP 7420402B2 JP 2021551413 A JP2021551413 A JP 2021551413A JP 2021551413 A JP2021551413 A JP 2021551413A JP 7420402 B2 JP7420402 B2 JP 7420402B2
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pai
carbon atoms
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潔 安藤
崇 八幡
敏男 宮田
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RenaScience Co Ltd
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    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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JP2021551413A 2019-09-30 2020-09-30 免疫チェックポイント分子の発現抑制剤 Active JP7420402B2 (ja)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113022A1 (ja) 2009-03-31 2010-10-07 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター－1阻害剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507297A (ja) 2002-05-13 2006-03-02 チルドレンズ・ホスピタル・ロサンジェルス ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防
US7951806B2 (en) 2007-07-25 2011-05-31 Renascience Co., Ltd. Plasminogen activator inhibitor-1 inhibitor
WO2009033095A2 (en) * 2007-09-07 2009-03-12 Cisthera, Incorporated Humanized pai-1 antibodies
EP2272822A4 (en) 2008-03-31 2012-01-18 Renascience Co Ltd PLASMINOG ACTIVATOR-1 HEMMER
JP5840324B2 (ja) * 2013-04-15 2016-01-06 株式会社レナサイエンス Ｐａｉ−１阻害剤の新規用途
HK1221725A1 (zh) 2013-08-13 2017-06-09 Sanofi 纤溶酶原激活剂抑制剂-1(pai-1)的抗体及其用途
JP2015147744A (ja) 2014-02-06 2015-08-20 国立大学法人浜松医科大学 Ｐａｉ−１阻害剤
PL3109320T3 (pl) 2014-02-21 2019-08-30 Astellas Pharma Inc. Nowe przeciwciało anty-ludzki PAI-1
JP2020088416A (ja) 2018-11-15 2020-06-04 シャープ株式会社 電子機器および制御装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010113022A1 (ja) 2009-03-31 2010-10-07 株式会社レナサイエンス プラスミノーゲンアクチベーターインヒビター－1阻害剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
VERONICA R Placencio, et al.，Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing.，Cancer Res.，2015年，Vol.75 No.15，p.2969-74.，doi: 10.1158/0008-5472.CAN-15-0876.
YADAV, P. et al.，Plasminogen activator inhibitor-1 promotes immunosuppression in cancer by modulating immune componen，Annals of Oncology，Vol.29 Supp.6，2018年，p.vi35-vi36. Abstract Number: 113P.，ISSN: 1569-8041、DOI 10.1093/annonc/mdy319
段孝, 他，ＰＡＩ－１阻害剤の新展開 －がん治療への臨床応用－，血栓止血誌，2018年，Vol.29 No.5，p.487-494.

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