JPWO2021062559A5 - - Google Patents

Info

Publication number

JPWO2021062559A5

JPWO2021062559A5 JP2022520062A JP2022520062A JPWO2021062559A5 JP WO2021062559 A5 JPWO2021062559 A5 JP WO2021062559A5 JP 2022520062 A JP2022520062 A JP 2022520062A JP 2022520062 A JP2022520062 A JP 2022520062A JP WO2021062559 A5 JPWO2021062559 A5 JP WO2021062559A5

Authority

JP

Japan

Prior art keywords

methyl

dihydroxy

biphenyl

pentyl

alkyl

Prior art date

2023-10-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 125000000217 alkyl group Chemical group 0.000 claims 110
• -1 C 1 -C 4 alkyl Chemical group 0.000 claims 99
• 229910052739 hydrogen Inorganic materials 0.000 claims 46
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 43
• 239000001257 hydrogen Substances 0.000 claims 41
• 150000001875 compounds Chemical class 0.000 claims 40
• 150000002431 hydrogen Chemical class 0.000 claims 28
• GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims 18
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 16
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 16
• 125000000753 cycloalkyl group Chemical group 0.000 claims 15
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 14
• 229910052757 nitrogen Inorganic materials 0.000 claims 13
• 125000004043 oxo group Chemical group O=* 0.000 claims 13
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 11
• 125000001072 heteroaryl group Chemical group 0.000 claims 11
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
• 239000002253 acid Substances 0.000 claims 10
• WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 10
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 10
• 239000004305 biphenyl Substances 0.000 claims 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 8
• 235000010290 biphenyl Nutrition 0.000 claims 8
• 125000003118 aryl group Chemical group 0.000 claims 7
• 229910052760 oxygen Inorganic materials 0.000 claims 7
• 229910052717 sulfur Inorganic materials 0.000 claims 7
• 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 6
• 229910052799 carbon Inorganic materials 0.000 claims 6
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 5
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 5
• 125000002393 azetidinyl group Chemical group 0.000 claims 5
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 4
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
• 125000005843 halogen group Chemical group 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
• 239000002207 metabolite Substances 0.000 claims 4
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
• 239000001301 oxygen Substances 0.000 claims 4
• OVPLZYJGTGDFNB-UHFFFAOYSA-N propan-2-yl carbamate Chemical compound CC(C)OC(N)=O OVPLZYJGTGDFNB-UHFFFAOYSA-N 0.000 claims 4
• 229920006395 saturated elastomer Polymers 0.000 claims 4
• 239000011593 sulfur Substances 0.000 claims 4
• JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 3
• RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
• KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims 3
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
• 125000002950 monocyclic group Chemical group 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 2
• 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 2
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
• 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 claims 2
• 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
• WSAFUNVSMWVPPV-UHFFFAOYSA-N CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3=C(C=CC(=C3)C)C(=C)C)O Chemical compound CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3=C(C=CC(=C3)C)C(=C)C)O WSAFUNVSMWVPPV-UHFFFAOYSA-N 0.000 claims 2
• NXJSMBCFWIROOC-UHFFFAOYSA-N CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3=CC=CC(=C3)C)O Chemical compound CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3=CC=CC(=C3)C)O NXJSMBCFWIROOC-UHFFFAOYSA-N 0.000 claims 2
• XCEKOCAXXNZYCY-UHFFFAOYSA-N CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3C=C(CCC3C(=C)C)C)O Chemical compound CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3C=C(CCC3C(=C)C)C)O XCEKOCAXXNZYCY-UHFFFAOYSA-N 0.000 claims 2
• LMDZKAPUBPPOQO-UHFFFAOYSA-N CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3CCCC(=C3)C)O Chemical compound CCCCCC1=CC(=C(C(=C1C(=O)N2CC2C)O)C3CCCC(=C3)C)O LMDZKAPUBPPOQO-UHFFFAOYSA-N 0.000 claims 2
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 2
• 102000018208 Cannabinoid Receptor Human genes 0.000 claims 2
• 108050007331 Cannabinoid receptor Proteins 0.000 claims 2
• RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
• 206010016654 Fibrosis Diseases 0.000 claims 2
• YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
• PIYRRMXSWNEWHL-UHFFFAOYSA-N N1(CC1)C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O Chemical compound N1(CC1)C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O PIYRRMXSWNEWHL-UHFFFAOYSA-N 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 206010057852 Nicotine dependence Diseases 0.000 claims 2
• JDSPXLLCHWPMEZ-UHFFFAOYSA-N OC1=C(C(=CC(=C1C(=O)N(C)CCOC)CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C Chemical compound OC1=C(C(=CC(=C1C(=O)N(C)CCOC)CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C JDSPXLLCHWPMEZ-UHFFFAOYSA-N 0.000 claims 2
• QQUSBXGWVRVMIL-UHFFFAOYSA-N OC1=C(C(=CC(=C1C(=O)N(C)OC)CCCCC)O)C1=CC(=CC=C1)C Chemical compound OC1=C(C(=CC(=C1C(=O)N(C)OC)CCCCC)O)C1=CC(=CC=C1)C QQUSBXGWVRVMIL-UHFFFAOYSA-N 0.000 claims 2
• XKFXTZLVCWQXQE-UHFFFAOYSA-N OC1=C(C(=CC(=C1C(=O)N(CC=1C=NC=CC=1)C)CCCCC)O)C1=CC(=CC=C1)C Chemical compound OC1=C(C(=CC(=C1C(=O)N(CC=1C=NC=CC=1)C)CCCCC)O)C1=CC(=CC=C1)C XKFXTZLVCWQXQE-UHFFFAOYSA-N 0.000 claims 2
• IKACXODQQZCULO-UHFFFAOYSA-N OC1=C(C(=CC(=C1C(=O)NC1=CC=C(C=C1)OC)CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C Chemical compound OC1=C(C(=CC(=C1C(=O)NC1=CC=C(C=C1)OC)CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C IKACXODQQZCULO-UHFFFAOYSA-N 0.000 claims 2
• 208000002193 Pain Diseases 0.000 claims 2
• GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
• NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
• 208000025569 Tobacco Use disease Diseases 0.000 claims 2
• 208000027418 Wounds and injury Diseases 0.000 claims 2
• 125000004069 aziridinyl group Chemical group 0.000 claims 2
• 208000019425 cirrhosis of liver Diseases 0.000 claims 2
• ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
• 208000014674 injury Diseases 0.000 claims 2
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
• KQNPFQTWMSNSAP-UHFFFAOYSA-M isobutyrate Chemical compound CC(C)C([O-])=O KQNPFQTWMSNSAP-UHFFFAOYSA-M 0.000 claims 2
• YNTOKMNHRPSGFU-UHFFFAOYSA-N n-Propyl carbamate Chemical compound CCCOC(N)=O YNTOKMNHRPSGFU-UHFFFAOYSA-N 0.000 claims 2
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• 125000006699 (C1-C3) hydroxyalkyl group Chemical group 0.000 claims 1
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
• 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 1
• 125000006455 1-cyclopentyl cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 125000006432 1-methyl cyclopropyl group Chemical group [H]C([H])([H])C1(*)C([H])([H])C1([H])[H] 0.000 claims 1
• UZNAUMYIUSSCLD-UHFFFAOYSA-N 2,4-dihydroxy-3-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)-6-pentylbenzamide Chemical compound C(CCCC1=CC(O)=C(C2C(C(=C)C)CCC(=C2)C)C(O)=C1C(=O)N)C UZNAUMYIUSSCLD-UHFFFAOYSA-N 0.000 claims 1
• 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
• 208000007848 Alcoholism Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 208000019901 Anxiety disease Diseases 0.000 claims 1
• 102000014461 Ataxins Human genes 0.000 claims 1
• 108010078286 Ataxins Proteins 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
• 206010003805 Autism Diseases 0.000 claims 1
• 208000020706 Autistic disease Diseases 0.000 claims 1
• 208000020925 Bipolar disease Diseases 0.000 claims 1
• GEJPSYJFOYZCRI-UHFFFAOYSA-N BrC1=C(CNC(=O)C=2C(=C(C(=CC=2CCCCC)O)C2=C(C=CC(=C2)C)C(=C)C)O)C=CC=C1 Chemical compound BrC1=C(CNC(=O)C=2C(=C(C(=CC=2CCCCC)O)C2=C(C=CC(=C2)C)C(=C)C)O)C=CC=C1 GEJPSYJFOYZCRI-UHFFFAOYSA-N 0.000 claims 1
• MEFBMWVPBIBUJZ-UHFFFAOYSA-N BrC1=C(CNC(=O)C=2C(=C(C(=CC=2CCCCC)O)C2=CC(=CC=C2)C)O)C=CC=C1 Chemical compound BrC1=C(CNC(=O)C=2C(=C(C(=CC=2CCCCC)O)C2=CC(=CC=C2)C)O)C=CC=C1 MEFBMWVPBIBUJZ-UHFFFAOYSA-N 0.000 claims 1
• SSOBPCYLRFFIBE-UHFFFAOYSA-N BrC1=C(CNC(=O)C=2C(=C(C(=CC=2CCCCC)O)C2C(CCC(=C2)C)C(=C)C)O)C=CC=C1 Chemical compound BrC1=C(CNC(=O)C=2C(=C(C(=CC=2CCCCC)O)C2C(CCC(=C2)C)C(=C)C)O)C=CC=C1 SSOBPCYLRFFIBE-UHFFFAOYSA-N 0.000 claims 1
• YVOMXAHEXLZGDQ-UHFFFAOYSA-N C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O)C Chemical compound C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O)C YVOMXAHEXLZGDQ-UHFFFAOYSA-N 0.000 claims 1
• NRMIXDLKMHNQJY-UHFFFAOYSA-N C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O)C Chemical compound C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O)C NRMIXDLKMHNQJY-UHFFFAOYSA-N 0.000 claims 1
• HKTANIHWZZBUBZ-UHFFFAOYSA-N C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O)C Chemical compound C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O)C HKTANIHWZZBUBZ-UHFFFAOYSA-N 0.000 claims 1
• JLBMREYGFGKFGH-UHFFFAOYSA-N C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1CCCC(=C1)C)O)C Chemical compound C(#N)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1CCCC(=C1)C)O)C JLBMREYGFGKFGH-UHFFFAOYSA-N 0.000 claims 1
• CGGUFJQDMNIMHQ-UHFFFAOYSA-N C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O Chemical compound C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O CGGUFJQDMNIMHQ-UHFFFAOYSA-N 0.000 claims 1
• UYYSHPIHHWRCDU-UHFFFAOYSA-N C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O Chemical compound C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O UYYSHPIHHWRCDU-UHFFFAOYSA-N 0.000 claims 1
• PRPXTJGIPHMHST-UHFFFAOYSA-N C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O Chemical compound C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O PRPXTJGIPHMHST-UHFFFAOYSA-N 0.000 claims 1
• GNQFZGHHGDNDNO-UHFFFAOYSA-N C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1CCCC(=C1)C)O Chemical compound C(C)(=O)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1CCCC(=C1)C)O GNQFZGHHGDNDNO-UHFFFAOYSA-N 0.000 claims 1
• BIQXCVSIOKZJHW-UHFFFAOYSA-N C(C)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O)CC Chemical compound C(C)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O)CC BIQXCVSIOKZJHW-UHFFFAOYSA-N 0.000 claims 1
• BXVQBJLRLNWJIL-UHFFFAOYSA-N C(C)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O)CC Chemical compound C(C)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O)CC BXVQBJLRLNWJIL-UHFFFAOYSA-N 0.000 claims 1
• BLAKJNDJNZNVGW-UHFFFAOYSA-N C(C)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O)CC Chemical compound C(C)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O)CC BLAKJNDJNZNVGW-UHFFFAOYSA-N 0.000 claims 1
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• AODZFEQWUZRPCV-UHFFFAOYSA-N C(C)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O Chemical compound C(C)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1C(CCC(=C1)C)C(=C)C)O AODZFEQWUZRPCV-UHFFFAOYSA-N 0.000 claims 1
• MOCQTMNJYCIESK-UHFFFAOYSA-N C(C)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1CCCC(=C1)C)O Chemical compound C(C)NC(=O)C=1C(=C(C(=CC=1CCCCC)O)C1CCCC(=C1)C)O MOCQTMNJYCIESK-UHFFFAOYSA-N 0.000 claims 1
• SEGVKOHCROJLNV-UHFFFAOYSA-N C(C1=CC=CC=C1)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O)C Chemical compound C(C1=CC=CC=C1)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=C(C=CC(=C1)C)C(=C)C)O)C SEGVKOHCROJLNV-UHFFFAOYSA-N 0.000 claims 1
• QRGMLNLKLDVUOS-UHFFFAOYSA-N C(C1=CC=CC=C1)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O)C Chemical compound C(C1=CC=CC=C1)N(C(=O)C=1C(=C(C(=CC=1CCCCC)O)C1=CC(=CC=C1)C)O)C QRGMLNLKLDVUOS-UHFFFAOYSA-N 0.000 claims 1
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