JPWO2021055835A5 - - Google Patents
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- Publication number
- JPWO2021055835A5 JPWO2021055835A5 JP2022518191A JP2022518191A JPWO2021055835A5 JP WO2021055835 A5 JPWO2021055835 A5 JP WO2021055835A5 JP 2022518191 A JP2022518191 A JP 2022518191A JP 2022518191 A JP2022518191 A JP 2022518191A JP WO2021055835 A5 JPWO2021055835 A5 JP WO2021055835A5
- Authority
- JP
- Japan
- Prior art keywords
- glycero
- compound according
- phosphocholine
- alkyl
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962902929P | 2019-09-19 | 2019-09-19 | |
| US62/902,929 | 2019-09-19 | ||
| PCT/US2020/051613 WO2021055835A1 (en) | 2019-09-19 | 2020-09-18 | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022549253A JP2022549253A (ja) | 2022-11-24 |
| JPWO2021055835A5 true JPWO2021055835A5 (hu) | 2023-09-26 |
Family
ID=72752506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022518191A Pending JP2022549253A (ja) | 2019-09-19 | 2020-09-18 | 治療薬の細胞内送達のためのカーボネート含有脂質化合物及び組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220411361A1 (hu) |
| EP (1) | EP4031521A1 (hu) |
| JP (1) | JP2022549253A (hu) |
| KR (1) | KR20220101076A (hu) |
| CN (1) | CN114728886B (hu) |
| AU (1) | AU2020351220A1 (hu) |
| BR (1) | BR112022004936A2 (hu) |
| CA (1) | CA3155015A1 (hu) |
| IL (1) | IL291339A (hu) |
| MX (1) | MX2022003285A (hu) |
| WO (1) | WO2021055835A1 (hu) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11969506B2 (en) | 2017-03-15 | 2024-04-30 | Modernatx, Inc. | Lipid nanoparticle formulation |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| US11066355B2 (en) | 2019-09-19 | 2021-07-20 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| EP4251170A1 (en) | 2020-11-25 | 2023-10-04 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| CN115197078B (zh) * | 2021-04-08 | 2024-06-04 | 厦门赛诺邦格生物科技股份有限公司 | 一种聚乙二醇化脂质及其修饰的脂质体、含该脂质体的药物组合物及其制剂和应用 |
| EP4342929A1 (en) * | 2021-06-30 | 2024-03-27 | Jenkem Technology Co. Ltd. (Tianjin) | Polyethylene glycol lipid and use thereof |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| MX2024002726A (es) | 2021-09-03 | 2024-03-20 | CureVac SE | Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos. |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| AR127892A1 (es) | 2021-12-10 | 2024-03-06 | Modernatx Inc | Compuestos y composiciones para la administración de agentes terapéuticos |
| US20230183168A1 (en) * | 2021-12-14 | 2023-06-15 | Massachusetts Institute Of Technology | Ionizable lipids and compositions and uses thereof |
| WO2023144330A1 (en) | 2022-01-28 | 2023-08-03 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| WO2023143601A1 (zh) * | 2022-01-30 | 2023-08-03 | 康希诺生物股份公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗 |
| WO2023143600A1 (zh) * | 2022-01-30 | 2023-08-03 | 康希诺生物股份公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗 |
| CN116554042A (zh) * | 2022-01-30 | 2023-08-08 | 康希诺生物股份公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物和疫苗 |
| TW202345863A (zh) | 2022-02-09 | 2023-12-01 | 美商現代公司 | 黏膜投與方法及調配物 |
| WO2023230587A2 (en) | 2022-05-25 | 2023-11-30 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2023227608A1 (en) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| WO2024022263A1 (zh) * | 2022-07-25 | 2024-02-01 | 苏州艾博生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
| WO2024023174A2 (en) | 2022-07-28 | 2024-02-01 | Aldexchem Kft. | Ionizable cationic lipids incorporating silicon |
| WO2024067639A1 (zh) * | 2022-09-30 | 2024-04-04 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| CN115784920B (zh) * | 2023-02-09 | 2023-05-12 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| CN116947669B (zh) * | 2022-09-30 | 2024-04-12 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| KR20240074652A (ko) | 2022-11-18 | 2024-05-28 | 한국생명공학연구원 | 활성 물질 전달을 위한 지질 화합물 및 조성물 |
| TW202428269A (zh) * | 2022-11-21 | 2024-07-16 | 西班牙商塞提斯生物技術公司 | 可離子化脂質及包含其的脂質奈米顆粒 |
| EP4371976A1 (en) * | 2022-11-21 | 2024-05-22 | Certest Biotec, S.L. | Ionizable lipids and lipid nanoparticles containing thereof |
| WO2024123978A1 (en) | 2022-12-08 | 2024-06-13 | Modernatx, Inc. | Ionizable lipids with malonate tails |
| CN118236344A (zh) * | 2022-12-15 | 2024-06-25 | 深圳瑞吉生物科技有限公司 | 一种核酸脂质纳米载体及其制备方法与应用 |
| WO2024140835A1 (zh) * | 2022-12-28 | 2024-07-04 | 仁景(苏州)生物科技有限公司 | 脂质化合物和脂质纳米颗粒组合物 |
| CN116178193B (zh) * | 2023-01-05 | 2023-07-28 | 北京悦康科创医药科技股份有限公司 | 高效低毒且稳定性表达的阳离子脂质化合物及其组合物 |
| WO2024165974A1 (en) * | 2023-02-09 | 2024-08-15 | Seqirus Inc. | Ionizable cationic compound |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024197307A1 (en) | 2023-03-23 | 2024-09-26 | Modernatx, Inc. | Peg targeting compounds for delivery of therapeutics |
| WO2024197310A1 (en) | 2023-03-23 | 2024-09-26 | Modernatx, Inc. | Peg targeting compounds for delivery of therapeutics |
| WO2024197309A1 (en) | 2023-03-23 | 2024-09-26 | Modernatx, Inc. | Peg targeting compounds for delivery of therapeutics |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3083579B1 (en) * | 2013-12-19 | 2022-01-26 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| HRP20221536T1 (hr) * | 2014-06-25 | 2023-02-17 | Acuitas Therapeutics Inc. | Novi lipidi i formulacije lipidnih nanočestica za isporuku nukleinskih kiselina |
| AU2016324463B2 (en) | 2015-09-17 | 2022-10-27 | Modernatx, Inc. | Polynucleotides containing a stabilizing tail region |
| JP6990176B2 (ja) | 2015-10-05 | 2022-02-03 | モデルナティエックス インコーポレイテッド | メッセンジャーリボ核酸薬物の治療投与のための方法 |
| FI3596041T3 (fi) * | 2017-03-15 | 2023-01-31 | Yhdiste ja koostumuksia terapeuttisten aineiden antamiseen solun sisään | |
| WO2018225871A1 (ja) * | 2017-06-09 | 2018-12-13 | 協和発酵キリン株式会社 | カチオン性脂質としての化合物 |
| WO2018232120A1 (en) * | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
-
2020
- 2020-09-18 AU AU2020351220A patent/AU2020351220A1/en not_active Abandoned
- 2020-09-18 KR KR1020227012366A patent/KR20220101076A/ko unknown
- 2020-09-18 BR BR112022004936A patent/BR112022004936A2/pt not_active Application Discontinuation
- 2020-09-18 CA CA3155015A patent/CA3155015A1/en active Pending
- 2020-09-18 EP EP20786367.1A patent/EP4031521A1/en active Pending
- 2020-09-18 CN CN202080080295.1A patent/CN114728886B/zh active Active
- 2020-09-18 WO PCT/US2020/051613 patent/WO2021055835A1/en unknown
- 2020-09-18 JP JP2022518191A patent/JP2022549253A/ja active Pending
- 2020-09-18 MX MX2022003285A patent/MX2022003285A/es unknown
- 2020-09-18 US US17/761,984 patent/US20220411361A1/en active Pending
-
2022
- 2022-03-14 IL IL291339A patent/IL291339A/en unknown
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