JPWO2021049504A5 - - Google Patents
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- Publication number
- JPWO2021049504A5 JPWO2021049504A5 JP2021545555A JP2021545555A JPWO2021049504A5 JP WO2021049504 A5 JPWO2021049504 A5 JP WO2021049504A5 JP 2021545555 A JP2021545555 A JP 2021545555A JP 2021545555 A JP2021545555 A JP 2021545555A JP WO2021049504 A5 JPWO2021049504 A5 JP WO2021049504A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- biantennary
- pharmaceutically acceptable
- acceptable salt
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019164564 | 2019-09-10 | ||
| PCT/JP2020/034022 WO2021049504A1 (ja) | 2019-09-10 | 2020-09-09 | 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021049504A1 JPWO2021049504A1 (es) | 2021-03-18 |
| JPWO2021049504A5 true JPWO2021049504A5 (es) | 2023-08-14 |
Family
ID=74866171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021545555A Pending JPWO2021049504A1 (es) | 2019-09-10 | 2020-09-09 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220378920A1 (es) |
| EP (1) | EP4029520A4 (es) |
| JP (1) | JPWO2021049504A1 (es) |
| KR (1) | KR20220061972A (es) |
| CN (1) | CN114616332A (es) |
| AU (1) | AU2020345317A1 (es) |
| BR (1) | BR112022004461A2 (es) |
| CA (1) | CA3150715A1 (es) |
| IL (1) | IL291251A (es) |
| TW (1) | TW202123973A (es) |
| WO (1) | WO2021049504A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023176862A1 (ja) * | 2022-03-16 | 2023-09-21 | 第一三共株式会社 | トランスフェリン受容体２の発現を抑制するｓｉＲＮＡ |
| WO2024075760A1 (ja) * | 2022-10-05 | 2024-04-11 | 第一三共株式会社 | ２分岐型ｎ－アセチル－ｄ－ガラクトサミン構造を有する化合物の製造方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0787982A (ja) | 1993-01-29 | 1995-04-04 | Sankyo Co Ltd | 修飾オリゴデオキシリボヌクレオチド |
| US6096881A (en) | 1997-05-30 | 2000-08-01 | Hybridon, Inc. | Sulfur transfer reagents for oligonucleotide synthesis |
| DE04020014T1 (de) | 1997-09-12 | 2006-01-26 | Exiqon A/S | Bi-zyklische - Nukleosid,Nnukleotid und Oligonukleotid-Analoga |
| EP1152009B2 (en) | 1999-02-12 | 2017-09-06 | Daiichi Sankyo Company, Limited | Novel nucleosides and oligonucleotide analogues |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| ES2215494T5 (es) | 2000-12-01 | 2017-12-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Moléculas de RNA pequeñas que median la interferencia de RNA |
| PT1527176E (pt) | 2002-08-05 | 2007-04-30 | Atugen Ag | Novas formas de muléculas de arn de interferência |
| EP2530156B1 (en) | 2002-11-25 | 2015-11-18 | Masafumi Matsuo | ENA nucleic acid drugs modifying splicing in mRNA precursor |
| EP2231195B1 (en) | 2007-12-04 | 2017-03-29 | Arbutus Biopharma Corporation | Targeting lipids |
| TWI455944B (zh) | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| WO2010052715A2 (en) | 2008-11-07 | 2010-05-14 | Ramot At Tel Aviv University Ltd. | Devices and methods for local treatment of cardiovascular diseases |
| WO2011053614A1 (en) | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Crystalline cdm-nag and methods for producing same |
| WO2012037254A1 (en) | 2010-09-15 | 2012-03-22 | Alnylam Pharmaceuticals, Inc. | MODIFIED iRNA AGENTS |
| EP2647713B1 (en) | 2010-12-02 | 2018-02-21 | Daiichi Sankyo Company, Limited | Modified single-strand polynucleotide |
| CN104837996A (zh) | 2012-11-15 | 2015-08-12 | 罗氏创新中心哥本哈根有限公司 | 抗apob反义缀合物化合物 |
| WO2014089146A1 (en) * | 2012-12-04 | 2014-06-12 | Isis Pharmaceuticals, Inc. | Compositions and methods for in vivo delivery of antisense compounds |
| JP6270742B2 (ja) | 2013-01-10 | 2018-01-31 | 塩野義製薬株式会社 | 架橋型核酸誘導体の製造方法 |
| JP6387084B2 (ja) * | 2013-05-01 | 2018-09-05 | アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | アポリポタンパク質ｃ−ｉｉｉの発現を調節するための組成物および方法 |
| TW201534578A (zh) | 2013-07-08 | 2015-09-16 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| AU2014287002A1 (en) | 2013-07-11 | 2016-02-11 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| WO2015105083A1 (ja) | 2014-01-07 | 2015-07-16 | 塩野義製薬株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| AU2015329974B2 (en) | 2014-10-10 | 2019-06-20 | F. Hoffmann-La Roche Ag | GaINAc phosphoramidites, nucleic acid conjugates thereof and their use |
| WO2017023817A1 (en) | 2015-07-31 | 2017-02-09 | Arcturus Therapeutics, Inc. | Multiligand agent for drug delivery |
| KR102117172B1 (ko) | 2015-11-16 | 2020-06-01 | 에프. 호프만-라 로슈 아게 | GalNAc 클러스터 포스포라미다이트 |
| WO2017131236A1 (ja) * | 2016-01-29 | 2017-08-03 | 協和発酵キリン株式会社 | 核酸複合体 |
| EP3442983A1 (en) * | 2016-04-14 | 2019-02-20 | H. Hoffnabb-La Roche Ag | TRITYL-MONO-Ga1NAc COMPOUNDS AND THEIR USE |
| WO2018013999A1 (en) * | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
| CA3049133A1 (en) * | 2017-01-18 | 2018-07-26 | Alnylam Pharmaceuticals, Inc. | Endosomal cleavable linkers |
| TW201920668A (zh) | 2017-08-02 | 2019-06-01 | 日商協和醱酵麒麟有限公司 | 核酸複合體 |
| JP6884268B2 (ja) * | 2018-03-09 | 2021-06-09 | 第一三共株式会社 | 糖原病Ｉａ型治療薬 |
| BR112021008539A2 (pt) * | 2018-11-08 | 2021-08-03 | Aligos Therapeutics, Inc. | polímeros de oligonucleotídeos e métodos de inibição de transporte de antígeno s |
-
2020
- 2020-09-09 CN CN202080077913.7A patent/CN114616332A/zh active Pending
- 2020-09-09 JP JP2021545555A patent/JPWO2021049504A1/ja active Pending
- 2020-09-09 BR BR112022004461A patent/BR112022004461A2/pt unknown
- 2020-09-09 AU AU2020345317A patent/AU2020345317A1/en active Pending
- 2020-09-09 US US17/641,741 patent/US20220378920A1/en active Pending
- 2020-09-09 WO PCT/JP2020/034022 patent/WO2021049504A1/ja unknown
- 2020-09-09 TW TW109130882A patent/TW202123973A/zh unknown
- 2020-09-09 CA CA3150715A patent/CA3150715A1/en active Pending
- 2020-09-09 EP EP20863189.5A patent/EP4029520A4/en active Pending
- 2020-09-09 KR KR1020227007900A patent/KR20220061972A/ko unknown
-
2022
- 2022-03-09 IL IL291251A patent/IL291251A/en unknown
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