JPWO2021033750A1 - - Google Patents

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Publication number
JPWO2021033750A1
JPWO2021033750A1 JP2021540980A JP2021540980A JPWO2021033750A1 JP WO2021033750 A1 JPWO2021033750 A1 JP WO2021033750A1 JP 2021540980 A JP2021540980 A JP 2021540980A JP 2021540980 A JP2021540980 A JP 2021540980A JP WO2021033750 A1 JPWO2021033750 A1 JP WO2021033750A1
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Japan
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JP2021540980A
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
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    • G01N15/1434Optical arrangements
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    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
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    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • G01N2015/1497Particle shape

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Fluid Mechanics (AREA)
  • Electromagnetism (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Signal Processing (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2021540980A 2019-08-21 2020-08-20 Pending JPWO2021033750A1 (ja)

Applications Claiming Priority (2)

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JP2019151212 2019-08-21
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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
US20210364496A1 (en) * 2020-05-21 2021-11-25 Nantbio, Inc. Interferometry Based Systems To Detect Small Mass Changes Of An Object In a Solution
US11788949B2 (en) * 2020-12-14 2023-10-17 Life Technologies Corporation Systems and methods for improved imaging and fluorescence in flow cytometry and other applications
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US20240027310A1 (en) * 2022-07-22 2024-01-25 Beckman Coulter, Inc. Biological sample staining module and biological analysis systems and methods
TWI825881B (zh) * 2022-07-29 2023-12-11 國立清華大學 細胞辨識方法
CN116698679B (zh) * 2023-07-27 2023-12-19 中国食品药品检定研究院 一种实时的微粒过滤效果测量装置及系统
CN117214068B (zh) * 2023-11-08 2024-01-26 季华实验室 一种运动微粒成像探测系统

Family Cites Families (16)

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JPS5136517A (en) 1974-09-24 1976-03-27 Tokyo Shibaura Electric Co Museiryuushidendoki no seigyosochi
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US20050085708A1 (en) * 2002-04-19 2005-04-21 University Of Washington System and method for preparation of cells for 3D image acquisition
JP3898103B2 (ja) 2002-08-26 2007-03-28 独立行政法人科学技術振興機構 細胞分析分離装置
EP1645621A4 (en) 2003-05-19 2009-08-05 Japan Science & Tech Corp APPARATUS FOR SEPARATING CELLS
JP4630015B2 (ja) 2004-08-03 2011-02-09 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞分離回収方法および細胞分離チップおよび細胞分離装置
JP4677254B2 (ja) 2005-03-07 2011-04-27 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞分離方法、細胞識別方法ならびに細胞検査方法
EP1807506B1 (en) * 2004-10-08 2013-04-17 Georgia Tech Research Corporation Microencapsulation of cells in hydrogels using electrostatic potentials
JP5170647B2 (ja) 2008-02-05 2013-03-27 国立大学法人 東京医科歯科大学 微粒子画像計測装置
US8143600B2 (en) * 2008-02-18 2012-03-27 Visiongate, Inc. 3D imaging of live cells with ultraviolet radiation
JP5580117B2 (ja) 2010-06-08 2014-08-27 公益財団法人神奈川科学技術アカデミー 細胞分析装置
WO2013147114A1 (ja) * 2012-03-30 2013-10-03 公益財団法人神奈川科学技術アカデミー イメージングセルソーター
JPWO2015053393A1 (ja) * 2013-10-10 2017-03-09 公益財団法人神奈川科学技術アカデミー イメージングセルソーター
GB201402591D0 (en) * 2014-02-14 2014-04-02 Memo Therapeutics Ag Method for recovering two or more genes, or gene products, encoding an immunoreceptor
JP2015188442A (ja) * 2014-03-31 2015-11-02 公益財団法人サントリー生命科学財団 セサミン生産用植物培養細胞およびそれを用いるセサミン製造方法
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