JPWO2021020362A5 - - Google Patents
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- Publication number
- JPWO2021020362A5 JPWO2021020362A5 JP2021535340A JP2021535340A JPWO2021020362A5 JP WO2021020362 A5 JPWO2021020362 A5 JP WO2021020362A5 JP 2021535340 A JP2021535340 A JP 2021535340A JP 2021535340 A JP2021535340 A JP 2021535340A JP WO2021020362 A5 JPWO2021020362 A5 JP WO2021020362A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- substituent
- ring
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 34
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 32
- 125000005843 halogen group Chemical group 0.000 claims 18
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 17
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000002950 monocyclic group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 125000005750 substituted cyclic group Chemical group 0.000 claims 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- FPJCZSVAGQWPJE-UHFFFAOYSA-N 2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxopyridazine-4-carboxamide Chemical compound FC(COC1=C(C=CC=C1)N1N=CC=C(C1=O)C(=O)NC1=CC=C(C=C1)C(C)(C)O)F FPJCZSVAGQWPJE-UHFFFAOYSA-N 0.000 claims 1
- OJTWEFXGDSAZLJ-UHFFFAOYSA-N 2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-3-oxopyridazine-4-carboxamide Chemical compound FC(COC1=C(C=CC=C1)N1N=C(C=C(C1=O)C(=O)NC1=CC=C(C=C1)C(C)(C)O)C)F OJTWEFXGDSAZLJ-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 208000006515 AB Variant Tay-Sachs Disease Diseases 0.000 claims 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 208000024720 Fabry Disease Diseases 0.000 claims 1
- 201000008892 GM1 Gangliosidosis Diseases 0.000 claims 1
- 208000015872 Gaucher disease Diseases 0.000 claims 1
- 201000002832 Lewy body dementia Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- CQAPXPSWLDAVEG-UHFFFAOYSA-N N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]pyridazine-4-carboxamide Chemical compound OC(C)(C)C1=CC=C(C=C1)NC(=O)C=1C(N(N=CC1)C1=C(C=CC=C1)OCC(F)(F)F)=O CQAPXPSWLDAVEG-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000021811 Sandhoff disease Diseases 0.000 claims 1
- 208000022292 Tay-Sachs disease Diseases 0.000 claims 1
- 239000003892 ceramide glucosyltransferase inhibitor Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229940125921 glucosylceramide synthase inhibitor Drugs 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019139174 | 2019-07-29 | ||
| JP2019139174 | 2019-07-29 | ||
| PCT/JP2020/028784 WO2021020362A1 (ja) | 2019-07-29 | 2020-07-28 | 複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021020362A1 JPWO2021020362A1 (https=) | 2021-02-04 |
| JPWO2021020362A5 true JPWO2021020362A5 (https=) | 2023-07-03 |
| JP7636326B2 JP7636326B2 (ja) | 2025-02-26 |
Family
ID=74228459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021535340A Active JP7636326B2 (ja) | 2019-07-29 | 2020-07-28 | 複素環化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220289679A1 (https=) |
| EP (1) | EP4005637A4 (https=) |
| JP (1) | JP7636326B2 (https=) |
| WO (1) | WO2021020362A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7539382B2 (ja) | 2019-07-29 | 2024-08-23 | 武田薬品工業株式会社 | 複素環化合物 |
| CN115925618A (zh) * | 2023-01-06 | 2023-04-07 | 河南省科学院化学研究所有限公司 | 一种2-(2,2,2-三氟乙氧基)-6-氯-3-氨基吡啶的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| WO2007103308A2 (en) | 2006-03-07 | 2007-09-13 | Array Biopharma Inc. | Heterobicyclic pyrazole compounds and methods of use |
| JPWO2009096435A1 (ja) * | 2008-01-29 | 2011-05-26 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| WO2009136663A1 (en) * | 2008-05-08 | 2009-11-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
| WO2010126914A1 (en) * | 2009-04-27 | 2010-11-04 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
| US20130109682A1 (en) * | 2010-07-06 | 2013-05-02 | Novartis Ag | Cyclic ether compounds useful as kinase inhibitors |
| EP2562174A1 (de) * | 2011-08-24 | 2013-02-27 | Bayer Cropscience AG | Herbizid wirksame 6-Oxo-1,6-dihydropyrimidin-5-carboxamide und 2-Oxo-1,2-dihydropyridin-3-carboxamide |
| UY34686A (es) * | 2012-03-20 | 2013-10-31 | Syngenta Ltd | ?compuestos herbicidas, sus usos, composiciones que los contienen y método para controlar malezas?. |
| MA37975B2 (fr) | 2012-09-11 | 2021-03-31 | Genzyme Corp | Inhibiteurs de synthase de glucosylcéramide |
| JP6493218B2 (ja) * | 2013-11-08 | 2019-04-03 | 小野薬品工業株式会社 | ピロロピリミジン誘導体 |
| EP3079695B1 (en) * | 2013-12-11 | 2021-03-17 | Genzyme Corporation | Glucosylceramide synthase inhibitors |
| CN106279147A (zh) * | 2015-05-21 | 2017-01-04 | 中国科学院上海药物研究所 | 一种吡啶并氮杂环化合物及其制备方法和用途 |
| KR102483020B1 (ko) * | 2016-03-28 | 2023-01-04 | 인사이트 코포레이션 | Tam 저해제로서의 피롤로트리아진 화합물 |
| AU2017269870A1 (en) | 2016-05-25 | 2018-12-06 | Bayer Pharma Aktiengesellschaft | 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides |
| WO2019151269A1 (ja) | 2018-01-31 | 2019-08-08 | 武田薬品工業株式会社 | 複素環化合物 |
| JP2019139174A (ja) | 2018-02-15 | 2019-08-22 | 三菱製紙株式会社 | 電子写真記録材料 |
-
2020
- 2020-07-28 US US17/630,442 patent/US20220289679A1/en active Pending
- 2020-07-28 EP EP20845923.0A patent/EP4005637A4/en active Pending
- 2020-07-28 WO PCT/JP2020/028784 patent/WO2021020362A1/ja not_active Ceased
- 2020-07-28 JP JP2021535340A patent/JP7636326B2/ja active Active
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