JPWO2020264201A5 - - Google Patents
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- Publication number
- JPWO2020264201A5 JPWO2020264201A5 JP2021577157A JP2021577157A JPWO2020264201A5 JP WO2020264201 A5 JPWO2020264201 A5 JP WO2020264201A5 JP 2021577157 A JP2021577157 A JP 2021577157A JP 2021577157 A JP2021577157 A JP 2021577157A JP WO2020264201 A5 JPWO2020264201 A5 JP WO2020264201A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- oral dosage
- lemborexant
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006186 oral dosage form Substances 0.000 claims 57
- MUGXRYIUWFITCP-PGRDOPGGSA-N (1r,2s)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-n-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide Chemical compound CC1=NC(C)=NC=C1OC[C@]1(C=2C=C(F)C=CC=2)[C@H](C(=O)NC=2N=CC(F)=CC=2)C1 MUGXRYIUWFITCP-PGRDOPGGSA-N 0.000 claims 46
- 229950003528 lemborexant Drugs 0.000 claims 46
- 150000003839 salts Chemical class 0.000 claims 44
- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 24
- 206010022437 insomnia Diseases 0.000 claims 24
- 239000000902 placebo Substances 0.000 claims 12
- 229940068196 placebo Drugs 0.000 claims 12
- 206010062519 Poor quality sleep Diseases 0.000 claims 11
- 238000002203 pretreatment Methods 0.000 claims 11
- 230000004620 sleep latency Effects 0.000 claims 9
- 230000003247 decreasing effect Effects 0.000 claims 6
- 230000007423 decrease Effects 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 230000004044 response Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 230000000422 nocturnal effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025076606A JP2025116005A (ja) | 2019-06-26 | 2025-05-02 | 睡眠問題の治療のためのレンボレキサント |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2019/003933 | 2019-06-26 | ||
| US2019003933 | 2019-06-26 | ||
| PCT/US2019/067955 WO2020263331A1 (en) | 2019-06-26 | 2019-12-20 | Lemborexant for treating sleep issues |
| USPCT/US2019/067955 | 2019-12-20 | ||
| PCT/US2020/039674 WO2020264201A1 (en) | 2019-06-26 | 2020-06-25 | Lemborexant for treating sleep issues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025076606A Division JP2025116005A (ja) | 2019-06-26 | 2025-05-02 | 睡眠問題の治療のためのレンボレキサント |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022538170A JP2022538170A (ja) | 2022-08-31 |
| JPWO2020264201A5 true JPWO2020264201A5 (enExample) | 2023-06-21 |
Family
ID=83059912
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021577157A Pending JP2022538170A (ja) | 2019-06-26 | 2020-06-25 | 睡眠問題の治療のためのレンボレキサント |
| JP2025076606A Pending JP2025116005A (ja) | 2019-06-26 | 2025-05-02 | 睡眠問題の治療のためのレンボレキサント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025076606A Pending JP2025116005A (ja) | 2019-06-26 | 2025-05-02 | 睡眠問題の治療のためのレンボレキサント |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP2022538170A (enExample) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015336463B2 (en) * | 2014-10-23 | 2020-06-18 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
| MX379318B (es) * | 2016-05-12 | 2025-03-10 | Eisai R&D Man Co Ltd | Metodos para tratar trastornos de sueño de ritmo circadiano. |
-
2020
- 2020-06-25 JP JP2021577157A patent/JP2022538170A/ja active Pending
-
2025
- 2025-05-02 JP JP2025076606A patent/JP2025116005A/ja active Pending
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