JPWO2020252589A5 - - Google Patents
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- JPWO2020252589A5 JPWO2020252589A5 JP2021574974A JP2021574974A JPWO2020252589A5 JP WO2020252589 A5 JPWO2020252589 A5 JP WO2020252589A5 JP 2021574974 A JP2021574974 A JP 2021574974A JP 2021574974 A JP2021574974 A JP 2021574974A JP WO2020252589 A5 JPWO2020252589 A5 JP WO2020252589A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- independently
- alkynyl
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962864064P | 2019-06-20 | 2019-06-20 | |
| US62/864,064 | 2019-06-20 | ||
| US201962877536P | 2019-07-23 | 2019-07-23 | |
| US62/877,536 | 2019-07-23 | ||
| US202063009104P | 2020-04-13 | 2020-04-13 | |
| US63/009,104 | 2020-04-13 | ||
| PCT/CA2020/050854 WO2020252589A1 (en) | 2019-06-20 | 2020-06-19 | Ionizable lipids for nucleic acid delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022537305A JP2022537305A (ja) | 2022-08-25 |
| JPWO2020252589A5 true JPWO2020252589A5 (enExample) | 2023-06-26 |
| JP7416096B2 JP7416096B2 (ja) | 2024-01-17 |
Family
ID=74036881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021574974A Active JP7416096B2 (ja) | 2019-06-20 | 2020-06-19 | 核酸送達のためのイオン化可能な脂質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12503432B2 (enExample) |
| EP (1) | EP3986866B1 (enExample) |
| JP (1) | JP7416096B2 (enExample) |
| KR (1) | KR102568997B1 (enExample) |
| CN (1) | CN114746401B (enExample) |
| CA (1) | CA3143577C (enExample) |
| DK (1) | DK3986866T3 (enExample) |
| ES (1) | ES2973521T3 (enExample) |
| WO (1) | WO2020252589A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7555123B2 (ja) | 2018-10-09 | 2024-09-24 | ザ ユニヴァーシティ オブ ブリティッシュ コロンビア | 有機溶媒不含かつ劣化剤不含のトランスフェクション・コンピテント・ベシクルを含む組成物及びシステム並びにそれらに関連する方法 |
| CN112888451A (zh) * | 2018-10-19 | 2021-06-01 | 川斯勒佰尔公司 | 信使rna的无泵包封 |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| US11591544B2 (en) | 2020-11-25 | 2023-02-28 | Akagera Medicines, Inc. | Ionizable cationic lipids |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| WO2023008793A1 (ko) | 2021-07-27 | 2023-02-02 | 에스케이바이오사이언스(주) | 단백질 발현을 위한 mrna와 이를 위한 주형 |
| CN115772089B (zh) * | 2021-09-07 | 2025-06-10 | 广州谷森制药有限公司 | 阳离子脂质化合物 |
| US11510975B1 (en) | 2021-11-29 | 2022-11-29 | Replicate Bioscience, Inc. | Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses |
| KR20250031230A (ko) | 2022-05-25 | 2025-03-06 | 아카제라 메디신즈, 인크. | 핵산 전달을 위한 지질 나노입자 및 이의 사용 방법 |
| WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
| KR20250120406A (ko) | 2022-12-12 | 2025-08-08 | 글로벌 라이프 사이언시즈 솔루션즈 캐나다 유엘씨 | 지질 나노입자 동결건조 방법 및 조성물 |
| KR102921785B1 (ko) * | 2022-12-19 | 2026-02-03 | 주식회사 녹십자 | 핵산 전달용 사이클로알칸계 지질 화합물 및 이를 포함하는 지질 나노입자 |
| WO2024133635A1 (en) | 2022-12-23 | 2024-06-27 | Biontech Delivery Technologies Gmbh | Composition |
| CN121666232A (zh) | 2023-05-31 | 2026-03-13 | 开普斯坦治疗公司 | 脂质纳米颗粒制剂和组合物 |
| AU2023457883A1 (en) | 2023-06-28 | 2025-12-18 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticle formulations for cell therapy and related methods |
| WO2025040724A1 (en) | 2023-08-21 | 2025-02-27 | Global Life Sciences Solutions Canada Ulc | Method and apparatus for ion flux lipid nanoparticle manufacture |
| WO2025049579A1 (en) | 2023-08-31 | 2025-03-06 | Global Life Sciences Solutions Canada Ulc | Intranasal formulation for pulmonary delivery of nanoparticles, compositions, uses, and manufacturing methods thereof |
| WO2025219528A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Non-destructive plasmid delivery to immune cells |
| WO2025219491A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Method and composition for hdr template dna delivery |
| WO2025224267A1 (en) | 2024-04-25 | 2025-10-30 | Global Life Sciences Solutions Canada Ulc | Method for producing a liquid composition including a nanoparticle, and formulation thereof |
| WO2026035680A1 (en) | 2024-08-06 | 2026-02-12 | Kernal Biologics, Inc. | Compositions and methods for delivery of agents |
| WO2026052844A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
| WO2026052854A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1539268A (en) | 1976-12-23 | 1979-01-31 | Ici Ltd | Prostane derivatives |
| JPH0822830B2 (ja) | 1988-10-19 | 1996-03-06 | 長谷川香料株式会社 | ２（ｚ）−ペンテニル置換シクロペンタン類およびその新規中間体 |
| JP2743198B2 (ja) | 1989-09-26 | 1998-04-22 | 長谷川香料株式会社 | シクロペンタン類 |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US6734171B1 (en) | 1997-10-10 | 2004-05-11 | Inex Pharmaceuticals Corp. | Methods for encapsulating nucleic acids in lipid bilayers |
| WO2003011443A2 (en) | 2001-07-27 | 2003-02-13 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| WO2008109238A1 (en) * | 2007-03-02 | 2008-09-12 | Janssen Pharmaceutica N.V. | Substituted cyclopentyl piperidine ccr2 antagonists |
| EP2224912B1 (en) | 2008-01-02 | 2016-05-11 | TEKMIRA Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| DK2355851T3 (en) | 2008-11-10 | 2018-06-25 | Arbutus Biopharma Corp | Newly known lipids and compositions for release of therapeutic agents |
| CA2764609C (en) | 2009-06-10 | 2018-10-02 | Alnylam Pharmaceuticals, Inc. | Improved cationic lipid of formula i |
| EP2496700B1 (en) | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| JP2014001142A (ja) | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
| JP5902197B2 (ja) | 2011-01-11 | 2016-04-13 | アルニラム・ファーマシューティカルズ・インコーポレーテッド | Ｐｅｇ化脂質および薬剤送達のためのそれらの使用 |
| TW201309621A (zh) | 2011-02-08 | 2013-03-01 | Daiichi Sankyo Co Ltd | 新穎脂質 |
| EP3069785A1 (en) | 2011-10-25 | 2016-09-21 | The University Of British Columbia | Limit size lipid nanoparticles and related methods |
| CN105143456A (zh) | 2013-03-15 | 2015-12-09 | 不列颠哥伦比亚大学 | 用于转染的脂质纳米粒子和相关方法 |
| CN108778477B (zh) | 2016-01-06 | 2022-02-25 | 不列颠哥伦比亚大学 | 分叉混合器及其使用和制造方法 |
| EP3481539A4 (en) | 2016-07-06 | 2020-02-26 | Precision Nanosystems Inc | INTELLIGENT MICROFLUIDIC MIXING INSTRUMENT AND CARTRIDGES |
| US11964057B2 (en) | 2017-06-20 | 2024-04-23 | Rjh Biosciences Inc. | Transfection reagents for delivery of nucleic acids |
| WO2019182527A1 (en) * | 2018-03-21 | 2019-09-26 | T.C. Istanbul Medipol Universitesi | Methyl jasmonate derivatives as possible drug candidates for use in treatment of cancer |
-
2020
- 2020-06-19 CN CN202080045008.3A patent/CN114746401B/zh active Active
- 2020-06-19 EP EP20826513.2A patent/EP3986866B1/en active Active
- 2020-06-19 JP JP2021574974A patent/JP7416096B2/ja active Active
- 2020-06-19 CA CA3143577A patent/CA3143577C/en active Active
- 2020-06-19 ES ES20826513T patent/ES2973521T3/es active Active
- 2020-06-19 KR KR1020227002023A patent/KR102568997B1/ko active Active
- 2020-06-19 US US17/620,575 patent/US12503432B2/en active Active
- 2020-06-19 DK DK20826513.2T patent/DK3986866T3/da active
- 2020-06-19 WO PCT/CA2020/050854 patent/WO2020252589A1/en not_active Ceased
-
2025
- 2025-09-24 US US19/338,244 patent/US20260078085A1/en active Pending
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