JPWO2020252294A5 - - Google Patents
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- Publication number
- JPWO2020252294A5 JPWO2020252294A5 JP2021573841A JP2021573841A JPWO2020252294A5 JP WO2020252294 A5 JPWO2020252294 A5 JP WO2020252294A5 JP 2021573841 A JP2021573841 A JP 2021573841A JP 2021573841 A JP2021573841 A JP 2021573841A JP WO2020252294 A5 JPWO2020252294 A5 JP WO2020252294A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyldiyl
- peg
- immunoconjugate
- pep
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962861139P | 2019-06-13 | 2019-06-13 | |
US62/861,139 | 2019-06-13 | ||
US202062963884P | 2020-01-21 | 2020-01-21 | |
US62/963,884 | 2020-01-21 | ||
PCT/US2020/037477 WO2020252294A1 (en) | 2019-06-13 | 2020-06-12 | Aminobenzazepine compounds, immunoconjugates, and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022537158A JP2022537158A (ja) | 2022-08-24 |
JPWO2020252294A5 true JPWO2020252294A5 (es) | 2023-06-16 |
Family
ID=71608047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021573841A Pending JP2022537158A (ja) | 2019-06-13 | 2020-06-12 | アミノベンズアゼピン化合物、イムノコンジュゲート、及びそれらの使用 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20200390899A1 (es) |
EP (1) | EP3983082A1 (es) |
JP (1) | JP2022537158A (es) |
KR (1) | KR20220034784A (es) |
CN (1) | CN114585390A (es) |
AU (1) | AU2020291014A1 (es) |
BR (1) | BR112021025034A2 (es) |
CA (1) | CA3142887A1 (es) |
IL (1) | IL288816A (es) |
MX (1) | MX2021015221A (es) |
TW (1) | TW202112752A (es) |
WO (1) | WO2020252294A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3484518A4 (en) | 2016-07-07 | 2020-04-22 | The Board of Trustees of the Leland Stanford Junior University | ANTIBODY ADJUVANT CONJUGATES |
WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
WO2021081407A1 (en) | 2019-10-25 | 2021-04-29 | Bolt Biotherapeutics, Inc. | Thienoazepine immunoconjugates, and uses thereof |
EP4093510A1 (en) * | 2020-01-21 | 2022-11-30 | Bolt Biotherapeutics, Inc. | Anti-pd-l1 antibodies |
EP4106819A1 (en) | 2020-02-21 | 2022-12-28 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
JP2023524271A (ja) * | 2020-05-08 | 2023-06-09 | ボルト バイオセラピューティクス、インコーポレーテッド | エラスターゼ-基質ペプチドリンカーイムノコンジュゲート、及びそれらの使用 |
WO2022006327A1 (en) | 2020-07-01 | 2022-01-06 | Silverback Therapeutics, Inc. | Anti-asgr1 antibody conjugates and uses thereof |
WO2022036101A1 (en) * | 2020-08-13 | 2022-02-17 | Bolt Biotherapeutics, Inc. | Pyrazoloazepine immunoconjugates, and uses thereof |
CN116897054A (zh) * | 2020-12-11 | 2023-10-17 | 博尔特生物治疗药物有限公司 | 抗her2免疫缀合物及其用途 |
US20220195066A1 (en) * | 2020-12-11 | 2022-06-23 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
WO2022125891A2 (en) * | 2020-12-11 | 2022-06-16 | Bolt Biotherapeutics, Inc. | Anti-cea immunoconjugates, and uses thereof |
US20240091370A1 (en) * | 2020-12-11 | 2024-03-21 | Bolt Biotherapeutics, Inc. | Anti-her2 immunoconjugates, and uses thereof |
IL303491A (en) * | 2020-12-11 | 2023-08-01 | Bolt Biotherapeutics Inc | Anti-PD-L1 immunoconjugates and uses thereof |
EP4277925A1 (en) * | 2021-01-14 | 2023-11-22 | Gritstone bio, Inc. | Multi-specific antibodies and methods of use |
JP2024512056A (ja) * | 2021-03-26 | 2024-03-18 | ボルト バイオセラピューティクス、インコーポレーテッド | 2-アミノ-4-カルボキサミド-ベンゾアゼピン免疫複合体、及びその使用 |
EP4313162A1 (en) * | 2021-03-26 | 2024-02-07 | Bolt Biotherapeutics, Inc. | 2-amino-4-carboxamide-benzazepine immunoconjugates, and uses thereof |
WO2023076599A1 (en) | 2021-10-29 | 2023-05-04 | Bolt Biotherapeutics, Inc. | Tlr agonist immunoconjugates with cysteine-mutant antibodies, and uses thereof |
TW202333737A (zh) * | 2021-12-16 | 2023-09-01 | 大陸商映恩生物製藥(蘇州)有限公司 | Tlr調節劑及其用途 |
TW202339806A (zh) * | 2022-02-09 | 2023-10-16 | 美商博特生物治療公司 | 8—磺醯基—苯并氮呯免疫結合物及其用途 |
WO2023154302A1 (en) * | 2022-02-09 | 2023-08-17 | Bolt Biotherapeutics, Inc. | Macromolecule-supported 8-sulfonyl-benzazepine compounds and their uses |
WO2023232142A1 (zh) * | 2022-06-02 | 2023-12-07 | 映恩生物制药(苏州)有限公司 | 一种药物化合物及其用途 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US723288A (en) | 1901-10-26 | 1903-03-24 | Harry South Lewis | Cipher-key for cryptographic codes. |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5874540A (en) | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
DE69907439T3 (de) | 1998-05-06 | 2014-01-02 | Genentech, Inc. | Reinigung von proteinen durch ionenaustauschchromatographie |
US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
US7416726B2 (en) | 2000-04-13 | 2008-08-26 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
US7273608B2 (en) | 2004-03-11 | 2007-09-25 | City Of Hope | Humanized anti-CEA T84.66 antibody and uses thereof |
CN101065151B (zh) | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
JP5399712B2 (ja) | 2005-12-21 | 2014-01-29 | アムゲン リサーチ (ミュンヘン) ゲーエムベーハー | 可溶性ceaに対する抵抗性を有する医薬組成物 |
AU2008251608B2 (en) | 2007-05-08 | 2014-03-27 | Genentech, Inc. | Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates |
BRPI0818780A2 (pt) | 2007-10-19 | 2015-04-22 | Genentech Inc | Anticorpo anti-tenb2 planejados por cisteína e conjugados de medicamento com anticorpos |
CN102822199B (zh) | 2010-02-04 | 2014-10-15 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
CA2816426A1 (en) | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
PL2681244T3 (pl) | 2011-03-02 | 2018-04-30 | Roche Glycart Ag | Przeciwciała przeciwko antygenowi rakowo-płodowemu |
MX348578B (es) | 2011-08-04 | 2017-06-20 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion de cancer. |
PL2740793T3 (pl) | 2011-08-04 | 2018-04-30 | Toray Industries, Inc. | Kompozycja leku do leczenia i/lub zapobiegania nowotworowi |
WO2013018889A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
CA2844030C (en) | 2011-08-04 | 2019-09-03 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
AU2013223147B2 (en) | 2012-02-21 | 2017-10-05 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
IN2014KN01713A (es) | 2012-02-21 | 2015-10-23 | Toray Industries | |
AU2013223161B2 (en) | 2012-02-21 | 2017-10-19 | Toray Industries, Inc. | Medicinal composition for treating and/or preventing cancer |
AU2013223137B2 (en) | 2012-02-21 | 2017-10-19 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
US9753038B2 (en) | 2012-07-19 | 2017-09-05 | Toray Industries, Inc. | Method for detecting cancer via measurement of caprin-1 expression level |
CA2879304C (en) | 2012-07-19 | 2020-07-14 | Toray Industries, Inc. | Method for detecting cancer |
EA039377B1 (ru) | 2012-11-20 | 2022-01-20 | Санофи | Антитела к ceacam5 и их применения |
AU2014303375B2 (en) | 2013-08-09 | 2019-07-04 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
PE20210168A1 (es) | 2014-02-10 | 2021-01-28 | Merck Patent Gmbh | INHIBICION DIRIGIDA DEL FACTOR DE CRECIMIENTO TRANSFORMADOR ß (TGFß) |
PE20170782A1 (es) | 2014-11-21 | 2017-07-04 | Bristol Myers Squibb Co | Anticuerpos frente a cd73 y usos de los mismos |
CN107148417B (zh) * | 2014-12-18 | 2020-09-08 | 豪夫迈·罗氏有限公司 | 苯并氮杂*磺酰胺化合物 |
KR20190075921A (ko) | 2016-10-28 | 2019-07-01 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
EP3574018A4 (en) * | 2017-01-27 | 2020-10-07 | Silverback Therapeutics, Inc. | CONJUGATES TARGETING TUMORS AND THEIR METHODS OF USE |
SG10202110182PA (en) * | 2017-03-15 | 2021-10-28 | Silverback Therapeutics Inc | Benzazepine compounds, conjugates, and uses thereof |
WO2019084060A1 (en) * | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS |
WO2019118884A1 (en) * | 2017-12-15 | 2019-06-20 | Silverback Therapeutics, Inc. | Antibody construct-drug conjugate for the treatment of hepatitis |
KR20210081339A (ko) * | 2018-09-12 | 2021-07-01 | 실버백 테라퓨틱스, 인크. | 치환된 벤즈아제핀 화합물, 접합체, 및 이의 용도 |
WO2020056194A1 (en) * | 2018-09-12 | 2020-03-19 | Silverback Therapeutics, Inc. | Benzazepine compounds, conjugates, and uses thereof |
MX2021002764A (es) * | 2018-09-12 | 2021-05-12 | Silverback Therapeutics Inc | Composiciones para el tratamiento de enfermedades con conjugados inmunoestimuladores. |
-
2020
- 2020-06-12 AU AU2020291014A patent/AU2020291014A1/en active Pending
- 2020-06-12 CN CN202080053101.9A patent/CN114585390A/zh active Pending
- 2020-06-12 US US16/900,193 patent/US20200390899A1/en active Pending
- 2020-06-12 BR BR112021025034A patent/BR112021025034A2/pt unknown
- 2020-06-12 EP EP20740106.8A patent/EP3983082A1/en active Pending
- 2020-06-12 MX MX2021015221A patent/MX2021015221A/es unknown
- 2020-06-12 TW TW109119949A patent/TW202112752A/zh unknown
- 2020-06-12 KR KR1020227001083A patent/KR20220034784A/ko active Search and Examination
- 2020-06-12 CA CA3142887A patent/CA3142887A1/en active Pending
- 2020-06-12 WO PCT/US2020/037477 patent/WO2020252294A1/en unknown
- 2020-06-12 JP JP2021573841A patent/JP2022537158A/ja active Pending
-
2021
- 2021-12-09 IL IL288816A patent/IL288816A/en unknown
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