JPWO2020245283A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020245283A5
JPWO2020245283A5 JP2021572333A JP2021572333A JPWO2020245283A5 JP WO2020245283 A5 JPWO2020245283 A5 JP WO2020245283A5 JP 2021572333 A JP2021572333 A JP 2021572333A JP 2021572333 A JP2021572333 A JP 2021572333A JP WO2020245283 A5 JPWO2020245283 A5 JP WO2020245283A5
Authority
JP
Japan
Prior art keywords
antibody
conjugate
seq
represented
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021572333A
Other languages
English (en)
Japanese (ja)
Other versions
JP7260677B2 (ja
JP2022535276A (ja
Publication date
Priority claimed from GBGB1908128.0A external-priority patent/GB201908128D0/en
Application filed filed Critical
Publication of JP2022535276A publication Critical patent/JP2022535276A/ja
Publication of JPWO2020245283A5 publication Critical patent/JPWO2020245283A5/ja
Application granted granted Critical
Publication of JP7260677B2 publication Critical patent/JP7260677B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021572333A 2019-06-07 2020-06-04 ピロロベンゾジアゼピン-抗体複合体 Active JP7260677B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1908128.0A GB201908128D0 (en) 2019-06-07 2019-06-07 Pyrrolobenzodiazepine-antibody conjugates
GB1908128.0 2019-06-07
PCT/EP2020/065506 WO2020245283A1 (en) 2019-06-07 2020-06-04 Pyrrolobenzodiazepine-antibody conjugates

Publications (3)

Publication Number Publication Date
JP2022535276A JP2022535276A (ja) 2022-08-05
JPWO2020245283A5 true JPWO2020245283A5 (he) 2022-11-16
JP7260677B2 JP7260677B2 (ja) 2023-04-18

Family

ID=67386092

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021572333A Active JP7260677B2 (ja) 2019-06-07 2020-06-04 ピロロベンゾジアゼピン-抗体複合体

Country Status (15)

Country Link
US (1) US11484606B2 (he)
EP (1) EP3980077A1 (he)
JP (1) JP7260677B2 (he)
KR (1) KR102495245B1 (he)
CN (1) CN114375204B (he)
AR (1) AR119086A1 (he)
AU (1) AU2020287248A1 (he)
BR (1) BR112021024646A2 (he)
CA (1) CA3142448A1 (he)
GB (1) GB201908128D0 (he)
IL (1) IL288681A (he)
MX (1) MX2021015101A (he)
SG (1) SG11202112821XA (he)
WO (1) WO2020245283A1 (he)
ZA (1) ZA202109660B (he)

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58180487A (ja) 1982-04-16 1983-10-21 Kyowa Hakko Kogyo Co Ltd 抗生物質dc−81およびその製造法
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5583024A (en) 1985-12-02 1996-12-10 The Regents Of The University Of California Recombinant expression of Coleoptera luciferase
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
JPH08336393A (ja) 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
US6218519B1 (en) 1996-04-12 2001-04-17 Pro-Neuron, Inc. Compounds and methods for the selective treatment of cancer and bacterial infections
CA2264227A1 (en) 1996-09-27 1998-04-02 Raymond A. Firestone Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
US6759509B1 (en) 1996-11-05 2004-07-06 Bristol-Myers Squibb Company Branched peptide linkers
US6602677B1 (en) 1997-09-19 2003-08-05 Promega Corporation Thermostable luciferases and methods of production
AU3733399A (en) 1998-05-22 1999-12-13 Daiichi Pharmaceutical Co., Ltd. Drug composites
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
US6268488B1 (en) 1999-05-25 2001-07-31 Barbas, Iii Carlos F. Prodrug activation using catalytic antibodies
US20040052793A1 (en) 2001-02-22 2004-03-18 Carter Paul J. Caspase activivated prodrugs therapy
US20040018194A1 (en) 2000-11-28 2004-01-29 Francisco Joseph A. Recombinant anti-CD30 antibodies and uses thereof
EP1243276A1 (en) 2001-03-23 2002-09-25 Franciscus Marinus Hendrikus De Groot Elongated and multiple spacers containing activatible prodrugs
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
WO2003026577A2 (en) 2001-09-24 2003-04-03 Seattle Genetics, Inc. P-amidobenzylethers in drug delivery agents
US7091186B2 (en) 2001-09-24 2006-08-15 Seattle Genetics, Inc. p-Amidobenzylethers in drug delivery agents
WO2003043583A2 (en) 2001-11-20 2003-05-30 Seattle Genetics, Inc. Treatment of immunological disorders using anti-cd30 antibodies
US20050180972A1 (en) 2002-07-31 2005-08-18 Wahl Alan F. Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders
AU2003256038A1 (en) 2002-08-30 2004-03-19 Ramot At Tel Aviv University Ltd. Self-immolative dendrimers releasing many active moieties upon a single activating event
WO2004043493A1 (en) 2002-11-14 2004-05-27 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
WO2005079479A2 (en) 2004-02-17 2005-09-01 Absalus, Inc. Super-humanized antibodies against respiratory syncytial virus
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
BRPI0516284A (pt) 2004-09-23 2008-09-02 Genentech Inc anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto
EP1844074B1 (en) 2005-02-03 2013-04-24 Antitope Limited Human antibodies and proteins
CN109053523B (zh) 2005-10-07 2022-03-25 埃克塞利希斯股份有限公司 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
RS52060B (en) 2006-01-25 2012-04-30 Sanofi CYTOTOXIC AGENTS CONTAINING NEW TOMAIMYCIN DERIVATIVES
JP5290276B2 (ja) 2007-05-08 2013-09-18 ジェネンテック, インコーポレイテッド システイン改変抗muc16抗体および抗体−薬物結合体
WO2009052249A1 (en) 2007-10-19 2009-04-23 Genentech, Inc. Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
CN102176873A (zh) 2008-10-15 2011-09-07 捷迈有限公司 髓内钉
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
NZ602933A (en) 2010-04-15 2014-09-26 Seattle Genetics Inc Pyrrolobenzodiazepines used to treat proliferative diseases
MX2012011900A (es) 2010-04-15 2013-03-21 Seattle Genetics Inc Conjugados de pirrolobenzodiazepina diana.
EA024730B1 (ru) 2010-04-15 2016-10-31 Медимьюн Лимитед Пирролбензодиазепиновые соединения, их конъюгаты, фармацевтические композиции, содержащие указанные конъюгаты, и применение указанных конъюгатов
WO2011130615A2 (en) 2010-04-15 2011-10-20 Dr. Reddy's Laboratories Ltd. Preparation of lacosamide
CA2888908A1 (en) 2011-03-31 2012-10-04 Alethia Biotherapeutics Inc. Antibodies against kidney associated antigen 1 and antigen binding fragments thereof
JP6282597B2 (ja) 2012-01-09 2018-02-21 アー・デー・ツェー・セラピューティクス・エス・アー 乳癌を治療する方法
MX364326B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina - anti-psma.
PT2906251T (pt) 2012-10-12 2017-12-04 Medimmune Ltd Conjugados de pirrolobenzodiazepina-anticorpo anti-cd22
MX364329B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina.
EP2906252B1 (en) * 2012-10-12 2017-06-14 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-her2 antibody conjugates
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2014057118A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
SI2906296T1 (en) * 2012-10-12 2018-06-29 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US20160106861A1 (en) 2013-04-26 2016-04-21 Spirogen Sarl Axl antibody-drug conjugate and its use for the treatment of cancer
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
EP3054984A1 (en) 2013-10-11 2016-08-17 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates
CA2968447A1 (en) 2014-11-25 2016-06-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms
GB201506409D0 (en) 2015-04-15 2015-05-27 Williams David G And Berkel Patricius H C Van And Howard Philip W Humanized anti-axl antibodies and their conjugates
GB201506402D0 (en) * 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506394D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506389D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506399D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506405D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506393D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506388D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Cancer Res Technology Ltd And Howard Philip W Site-specific antibody-drug conjugates
GB201506407D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201507827D0 (en) 2015-05-07 2015-06-17 Adc Therapeutics Sarl Diagnostic test
GB201513607D0 (en) 2015-07-31 2015-09-16 Feingold Jay M Pyrrolobenzodiazepine-antibody conjugates
GB201602363D0 (en) 2016-02-10 2016-03-23 Adc Therapeutics Sa And Medimmune Ltd Pyrrolobenzodiazepine conjugates
UA123889C2 (uk) * 2017-02-08 2021-06-16 Ейдісі Терапьютікс Са Кон'югати піролобензодіазепін-антитіло
GB201702031D0 (en) * 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
DK3544636T3 (da) 2017-02-08 2021-05-10 Adc Therapeutics Sa Pyrrolobenzodiazepin-antistof-konjugater
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
MX2019012462A (es) 2017-04-20 2020-07-27 Adc Therapeutics Sa Terapia combinada.
BR112019021680A2 (pt) 2017-04-20 2020-05-12 Adc Therapeutics Sa Terapia de combinação com conjugado anticorpo-fármaco anti-cd25??
EP3612235A1 (en) 2017-04-20 2020-02-26 ADC Therapeutics SA Combination therapy with an anti-psma antibody-drug conjugate
MX2019014923A (es) 2017-06-14 2020-08-06 Adc Therapeutics Sa Régimen de dosificación.
UA127900C2 (uk) 2017-06-14 2024-02-07 Ейдісі Терапьютікс Са Схема дозування для введення adc до cd19
AU2019272838A1 (en) * 2018-05-23 2020-11-26 Adc Therapeutics Sa Molecular adjuvant
WO2020127573A1 (en) * 2018-12-19 2020-06-25 Adc Therapeutics Sa Pyrrolobenzodiazepine resistance

Similar Documents

Publication Publication Date Title
JP2023179713A5 (he)
JP2012522513A5 (he)
RU2483080C2 (ru) Антитела и иммуноконъюгаты и их применение
JP2022101693A5 (he)
JP2012522512A5 (he)
RU2011144119A (ru) АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2016098233A5 (he)
RU2011144141A (ru) АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2015509947A5 (he)
JP2020509027A5 (he)
JP2017514461A5 (he)
JP2021501162A5 (he)
JP2015533781A5 (he)
JP2006521286A5 (he)
JP2016538318A5 (he)
JP2010523469A5 (he)
JP2020500834A5 (he)
JP2010520290A5 (he)
JP2024016024A5 (he)
JP2023037000A5 (he)
US20190134215A1 (en) Combination of cd33 antibody drug conjugates with chemotherapeutic agents
JPWO2021213434A5 (he)
US20220387404A1 (en) Treatment of cancer using a combination comprising multi-tyrosine kinase inhibitor and immune checkpoint inhibitor
JPWO2019243159A5 (he)
JP2020531003A5 (he)