JPWO2020239999A5 - - Google Patents
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- Publication number
- JPWO2020239999A5 JPWO2020239999A5 JP2021570919A JP2021570919A JPWO2020239999A5 JP WO2020239999 A5 JPWO2020239999 A5 JP WO2020239999A5 JP 2021570919 A JP2021570919 A JP 2021570919A JP 2021570919 A JP2021570919 A JP 2021570919A JP WO2020239999 A5 JPWO2020239999 A5 JP WO2020239999A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- ethynyl
- pyrimidin
- hydroxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855144P | 2019-05-31 | 2019-05-31 | |
| US62/855,144 | 2019-05-31 | ||
| US201962907833P | 2019-09-30 | 2019-09-30 | |
| US62/907,833 | 2019-09-30 | ||
| PCT/EP2020/065024 WO2020239999A1 (en) | 2019-05-31 | 2020-05-29 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022534302A JP2022534302A (ja) | 2022-07-28 |
| JPWO2020239999A5 true JPWO2020239999A5 (es) | 2023-06-05 |
Family
ID=71108552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021570919A Pending JP2022534302A (ja) | 2019-05-31 | 2020-05-29 | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11254673B2 (es) |
| EP (1) | EP3976597A1 (es) |
| JP (1) | JP2022534302A (es) |
| KR (1) | KR20220027871A (es) |
| CN (1) | CN114222737A (es) |
| AU (1) | AU2020282005A1 (es) |
| BR (1) | BR112021023796A2 (es) |
| CA (1) | CA3143350A1 (es) |
| CL (1) | CL2021003142A1 (es) |
| CO (1) | CO2021017838A2 (es) |
| CR (1) | CR20210587A (es) |
| DO (1) | DOP2021000244A (es) |
| EC (1) | ECSP21093623A (es) |
| IL (1) | IL288387A (es) |
| JO (1) | JOP20210318A1 (es) |
| MA (1) | MA56038A (es) |
| MX (1) | MX2021014679A (es) |
| PE (1) | PE20220768A1 (es) |
| SG (1) | SG11202112994WA (es) |
| TW (1) | TW202110842A (es) |
| UY (1) | UY38721A (es) |
| WO (1) | WO2020239999A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022534302A (ja) * | 2019-05-31 | 2022-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| WO2023217906A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidinone derivatives as inhibitors of nf kappa b inducing kinase |
| WO2023217879A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidione derivatives as inhibitors of nf kappa b inducing kinase |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US7132428B2 (en) | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| EP1773781A2 (en) * | 2004-08-03 | 2007-04-18 | Wyeth | Indazoles useful in treating cardiovascular diseases |
| WO2006053277A2 (en) | 2004-11-12 | 2006-05-18 | Chippac, Inc. | Wire bond interconnection |
| WO2009158011A1 (en) * | 2008-06-26 | 2009-12-30 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| WO2010042337A1 (en) | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| EP2686314A1 (en) * | 2011-03-16 | 2014-01-22 | F.Hoffmann-La Roche Ag | 6,5-heterocyclic propargylic alcohol compounds and uses therefor |
| RU2014136578A (ru) * | 2012-02-17 | 2016-04-10 | Ф. Хоффманн-Ля Рош Аг | Трициклические соединения и способы их применения |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| MX2016002241A (es) | 2013-08-22 | 2016-05-31 | Hoffmann La Roche | Alcoholes de alquinilo y metodos de uso. |
| JP2016533385A (ja) * | 2013-08-22 | 2016-10-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルキニルアルコール及び使用方法 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| BR112017008045A2 (pt) | 2014-10-23 | 2017-12-19 | Janssen Pharmaceutica Nv | compostos como inibidores de nik |
| MX371151B (es) | 2014-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK). |
| BR112017007704B1 (pt) | 2014-10-23 | 2023-04-11 | Janssen Pharmaceutica N.V | Derivados de pirazolopirimidina como inibidores de nik, seu uso e composição farmacêutica que os compreende |
| AU2015334916B2 (en) | 2014-10-23 | 2020-02-06 | Janssen Pharmaceutica Nv | New pyrazole derivatives as NIK inhibitors |
| JP2018510140A (ja) | 2015-02-25 | 2018-04-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルキニルアルコール及び使用方法 |
| US11180487B2 (en) | 2016-01-22 | 2021-11-23 | Janssen Pharmaceutica Nv | Substituted cyanoindoline derivatives as NIK inhibitors |
| CA3012031C (en) | 2016-01-22 | 2024-03-26 | Janssen Pharmaceutica Nv | 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors |
| WO2018002217A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Heteroaromatic derivatives as nik inhibitors |
| KR102587619B1 (ko) | 2016-06-30 | 2023-10-11 | 잔센파마슈티카엔.브이. | Nik 억제제로서의 시아노인돌린 유도체 |
| CN109863142B (zh) * | 2016-08-24 | 2022-06-10 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| CN109641894B (zh) | 2016-08-24 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| IL271808B (en) | 2017-07-06 | 2022-08-01 | Janssen Pharmaceutica Nv | Novel mutated azaindoline histories as nik inhibitors |
| CN109810110B (zh) * | 2017-11-22 | 2023-01-24 | 中国科学院上海药物研究所 | 一种具有2-氨基嘧啶结构的化合物，其制备方法和用途 |
| MA56046A (fr) | 2019-05-31 | 2022-04-06 | Sage Therapeutics Inc | Stéroïdes neuroactifs et compositions associées |
| CN114269432B (zh) | 2019-05-31 | 2024-05-07 | 奇斯药制品公司 | 作为p2x3抑制剂的氨基喹唑啉衍生物 |
| WO2020243423A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| JP2022534302A (ja) * | 2019-05-31 | 2022-07-28 | ヤンセン ファーマシューティカ エヌ．ベー． | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
| KR20220030222A (ko) | 2019-05-31 | 2022-03-10 | 이케나 온콜로지, 인코포레이티드 | Tead 억제제 및 이의 용도 |
| KR20220075382A (ko) | 2019-09-30 | 2022-06-08 | 인사이트 코포레이션 | 면역조절제로서의 피리도[3,2-d]피리미딘 화합물 |
-
2020
- 2020-05-29 JP JP2021570919A patent/JP2022534302A/ja active Pending
- 2020-05-29 CA CA3143350A patent/CA3143350A1/en active Pending
- 2020-05-29 CR CR20210587A patent/CR20210587A/es unknown
- 2020-05-29 PE PE2021001987A patent/PE20220768A1/es unknown
- 2020-05-29 MX MX2021014679A patent/MX2021014679A/es unknown
- 2020-05-29 UY UY0001038721A patent/UY38721A/es unknown
- 2020-05-29 BR BR112021023796A patent/BR112021023796A2/pt unknown
- 2020-05-29 AU AU2020282005A patent/AU2020282005A1/en active Pending
- 2020-05-29 MA MA056038A patent/MA56038A/fr unknown
- 2020-05-29 TW TW109118004A patent/TW202110842A/zh unknown
- 2020-05-29 JO JOP/2021/0318A patent/JOP20210318A1/ar unknown
- 2020-05-29 SG SG11202112994WA patent/SG11202112994WA/en unknown
- 2020-05-29 WO PCT/EP2020/065024 patent/WO2020239999A1/en active Application Filing
- 2020-05-29 KR KR1020217042635A patent/KR20220027871A/ko unknown
- 2020-05-29 CN CN202080057418.XA patent/CN114222737A/zh active Pending
- 2020-05-29 EP EP20733688.4A patent/EP3976597A1/en active Pending
- 2020-05-29 US US16/887,889 patent/US11254673B2/en active Active
-
2021
- 2021-11-25 CL CL2021003142A patent/CL2021003142A1/es unknown
- 2021-11-25 IL IL288387A patent/IL288387A/en unknown
- 2021-11-26 DO DO2021000244A patent/DOP2021000244A/es unknown
- 2021-12-13 US US17/549,057 patent/US11827634B2/en active Active
- 2021-12-27 CO CONC2021/0017838A patent/CO2021017838A2/es unknown
- 2021-12-28 EC ECSENADI202193623A patent/ECSP21093623A/es unknown
-
2023
- 2023-09-27 US US18/475,499 patent/US20240199605A1/en active Pending
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