JPWO2020219287A5 - - Google Patents
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- JPWO2020219287A5 JPWO2020219287A5 JP2021563605A JP2021563605A JPWO2020219287A5 JP WO2020219287 A5 JPWO2020219287 A5 JP WO2020219287A5 JP 2021563605 A JP2021563605 A JP 2021563605A JP 2021563605 A JP2021563605 A JP 2021563605A JP WO2020219287 A5 JPWO2020219287 A5 JP WO2020219287A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- gly
- val
- phe
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962839440P | 2019-04-26 | 2019-04-26 | |
US62/839,440 | 2019-04-26 | ||
US201962875169P | 2019-07-17 | 2019-07-17 | |
US62/875,169 | 2019-07-17 | ||
US202062978159P | 2020-02-18 | 2020-02-18 | |
US62/978,159 | 2020-02-18 | ||
PCT/US2020/027831 WO2020219287A1 (en) | 2019-04-26 | 2020-04-10 | Camptothecin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022529854A JP2022529854A (ja) | 2022-06-24 |
JPWO2020219287A5 true JPWO2020219287A5 (fi) | 2023-04-19 |
Family
ID=70465562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021563605A Pending JP2022529854A (ja) | 2019-04-26 | 2020-04-10 | カンプトテシン誘導体 |
Country Status (19)
Country | Link |
---|---|
US (2) | US11229639B2 (fi) |
EP (2) | EP3958977B1 (fi) |
JP (1) | JP2022529854A (fi) |
KR (1) | KR20220027828A (fi) |
CN (1) | CN113766954A (fi) |
AU (1) | AU2020263231A1 (fi) |
CA (1) | CA3137125A1 (fi) |
DK (1) | DK3958977T3 (fi) |
ES (1) | ES2966473T3 (fi) |
FI (1) | FI3958977T3 (fi) |
HR (1) | HRP20231619T1 (fi) |
IL (1) | IL286846A (fi) |
LT (1) | LT3958977T (fi) |
PL (1) | PL3958977T3 (fi) |
PT (1) | PT3958977T (fi) |
RS (1) | RS64961B1 (fi) |
SG (1) | SG11202110922QA (fi) |
TW (1) | TW202106691A (fi) |
WO (1) | WO2020219287A1 (fi) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210283125A1 (en) * | 2020-02-25 | 2021-09-16 | Mediboston, Inc. | Camptothecin derivatives and conjugates thereof |
EP4289851A1 (en) * | 2021-02-05 | 2023-12-13 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor, and application thereof |
EP4257154A1 (en) * | 2021-02-09 | 2023-10-11 | Medilink Therapeutics (Suzhou) Co., Ltd. | Bioactive substance conjugate, preparation method therefor and use thereof |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
CN117769555A (zh) | 2021-08-19 | 2024-03-26 | 先声再明医药有限公司 | 喜树碱衍生物、其药物组合物及其应用 |
CN117881431A (zh) * | 2021-08-24 | 2024-04-12 | 昆山新蕴达生物科技有限公司 | 一种由可断裂连接子偶联的抗体偶联药物 |
WO2023030364A1 (zh) * | 2021-09-01 | 2023-03-09 | 上海弼领生物技术有限公司 | 一种喜树碱类化合物、其制备方法和用途 |
WO2023131219A1 (en) * | 2022-01-06 | 2023-07-13 | Virtuoso Binco, Inc. | Conjugates, compositions and methods of use |
WO2023143208A1 (zh) * | 2022-01-26 | 2023-08-03 | 苏州宜联生物医药有限公司 | 一种药物连接体偶联物的制备方法 |
WO2023180490A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
WO2023180489A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
WO2023180485A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing trop-2 |
WO2023180484A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing ptk7 |
WO2023207773A1 (en) * | 2022-04-29 | 2023-11-02 | Shanghai Micurx Pharmaceutical Co., Ltd. | Ligand-drug conjugate of camptothecin analogs, intermediates, preparation method therefor, pharmaceutical composition and application thereof |
WO2023231988A1 (zh) * | 2022-05-30 | 2023-12-07 | 苏州宜联生物医药有限公司 | 一种药物连接体偶联物的制备方法及其中间体 |
EP4285935A1 (en) * | 2022-06-03 | 2023-12-06 | Emergence Therapeutics AG | Novel anti-nectin-4 antibody camptothecin derivative conjugates |
WO2024015830A1 (en) | 2022-07-12 | 2024-01-18 | Cytomx Therapeutics, Inc. | Epcam immunoconjugates and uses thereof |
TW202404647A (zh) * | 2022-07-14 | 2024-02-01 | 大陸商蘇州宜聯生物醫藥有限公司 | 抗體藥物偶聯物及其製備方法和用途 |
EP4309676A1 (en) * | 2022-07-22 | 2024-01-24 | Emergence Therapeutics AG | Novel anti-nectin-4 antibody camptothecin derivative conjugates |
WO2024020734A1 (en) * | 2022-07-25 | 2024-02-01 | Immunogen, Inc. | Novel processes for preparing camptothecin derivatives |
CN117510515A (zh) * | 2022-07-28 | 2024-02-06 | 明慧医药(杭州)有限公司 | 适用于抗体-药物偶联物的毒素分子 |
WO2024054089A1 (ko) * | 2022-09-08 | 2024-03-14 | 주식회사 피노바이오 | 신규 캄토테신 유도체 및 이를 포함하는 운반체-약물 접합체 |
CN116253741B (zh) * | 2022-12-30 | 2024-02-02 | 上海禧耀医药科技有限公司 | 一种贝洛替康衍生物的合成方法 |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US20080152586A1 (en) | 1992-09-25 | 2008-06-26 | Avipep Pty Limited | High avidity polyvalent and polyspecific reagents |
US6355780B1 (en) | 1995-02-22 | 2002-03-12 | Yeda Research And Development Co. Ltd. | Antibodies to the death domain motifs of regulatory proteins |
DE19640207A1 (de) * | 1996-09-30 | 1998-04-02 | Bayer Ag | Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung) |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
ATE349438T1 (de) | 1999-11-24 | 2007-01-15 | Immunogen Inc | Cytotoxische wirkstoffe enthaltend taxane und deren therapeutische anwendung |
US6268375B1 (en) * | 1999-12-29 | 2001-07-31 | Research Triangle Institute | 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition |
ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
US8877901B2 (en) * | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
ATE499116T1 (de) | 2002-08-16 | 2011-03-15 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
AU2003285878B2 (en) | 2002-11-07 | 2011-04-28 | Immunogen, Inc. | Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
EP1718667B1 (en) | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
AU2006213662B2 (en) | 2005-02-11 | 2010-08-05 | Immunogen, Inc. | Process for preparing stable drug conjugates |
CA2614512C (en) | 2005-07-08 | 2014-01-07 | University Of Zuerich | Phage display using cotranslational translocation of fusion polypeptides |
ES2533992T3 (es) | 2005-08-24 | 2015-04-16 | Immunogen, Inc. | Procedimiento para preparar conjugados de anticuerpo maitansinoide |
EP1919931A4 (en) | 2005-08-31 | 2010-01-20 | Univ California | CELLULAR LIBRARIES OF PEPTIDE SEQUENCES (CLIPS) AND METHODS OF USE THEREOF |
WO2007062466A1 (en) | 2005-11-29 | 2007-06-07 | The University Of Sydney | Demibodies: dimerisation-activated therapeutic agents |
WO2007098611A1 (en) | 2006-03-03 | 2007-09-07 | Queen's University At Kingston | Compositions for treatment of cancer |
WO2007140371A2 (en) | 2006-05-30 | 2007-12-06 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
US8301398B2 (en) | 2006-06-22 | 2012-10-30 | Walter And Eliza Hall Institute Of Medical Research | Structure of the insulin receptor ectodomain |
CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
WO2009040338A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zürich | Designed armadillo repeat proteins |
EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
KR20230003298A (ko) | 2008-04-30 | 2023-01-05 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
KR101098335B1 (ko) | 2008-07-18 | 2011-12-26 | 성균관대학교산학협력단 | 신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 |
PL2356269T3 (pl) | 2008-10-31 | 2016-12-30 | Kompozycje białek rusztowania oparte na domenie fibronektyny typu III, sposoby i zastosowania | |
EP2385955B1 (en) | 2009-01-12 | 2020-08-12 | CytomX Therapeutics, Inc. | Modified antibody compositions, methods of making and using thereof |
CN102596992B (zh) | 2009-02-12 | 2015-09-09 | 詹森生物科技公司 | 基于ⅲ型纤连蛋白结构域的支架组合物、方法及用途 |
SG181814A1 (en) | 2009-12-23 | 2012-07-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
SG10201501342UA (en) | 2010-02-24 | 2015-04-29 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
MX338932B (es) | 2010-03-12 | 2016-05-06 | Immunogen Inc | Moleculas de union cd37 y sus inmunoconjugados. |
EP3569256B1 (en) | 2010-04-30 | 2022-06-15 | Janssen Biotech, Inc. | Stabilized fibronectin domain compositions, methods and uses |
EA201390472A1 (ru) | 2010-10-29 | 2014-02-28 | Иммьюноджен, Инк. | Новые молекулы, связывающиеся с egfr, и их иммуноконъюгаты |
AU2011320318B9 (en) | 2010-10-29 | 2015-11-19 | Immunogen, Inc. | Non-antagonistic EGFR-binding molecules and immunoconjugates thereof |
RU2748733C2 (ru) | 2011-02-15 | 2021-05-31 | Иммуноджен, Инк. | Цитотоксические производные бензодиазепина |
SG193514A1 (en) | 2011-04-01 | 2013-10-30 | Immunogen Inc | Methods for increasing efficacy of folr1 cancer therapy |
EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
WO2014026136A2 (en) | 2012-08-10 | 2014-02-13 | Cytomx Therapeutics, Inc. | Protease-resistant systems for polypeptide display and methods of making and using thereof |
AU2014324884B2 (en) | 2013-09-25 | 2020-03-26 | Cytomx Therapeutics, Inc | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
KR102535900B1 (ko) * | 2013-12-25 | 2023-05-26 | 다이이찌 산쿄 가부시키가이샤 | 항 trop2 항체-약물 컨쥬게이트 |
WO2015116933A2 (en) | 2014-01-31 | 2015-08-06 | Cytomx Therapeutics, Inc. | Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof |
MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
EA201792414A1 (ru) | 2015-05-04 | 2018-06-29 | Сайтомкс Терапьютикс, Инк. | Антитела против cd166, активируемые антитела против cd166 и способы их применения |
HUE058664T2 (hu) | 2016-12-23 | 2022-09-28 | Immunogen Inc | ADAM9-et célzó immunkonjugátumok és eljárások azok felhasználására |
IL277748B1 (en) * | 2018-04-06 | 2024-03-01 | Seagen Inc | Camptothecin peptide conjugates |
-
2020
- 2020-04-10 FI FIEP20722197.9T patent/FI3958977T3/fi active
- 2020-04-10 RS RS20231182A patent/RS64961B1/sr unknown
- 2020-04-10 PT PT207221979T patent/PT3958977T/pt unknown
- 2020-04-10 WO PCT/US2020/027831 patent/WO2020219287A1/en active Application Filing
- 2020-04-10 TW TW109112170A patent/TW202106691A/zh unknown
- 2020-04-10 ES ES20722197T patent/ES2966473T3/es active Active
- 2020-04-10 CA CA3137125A patent/CA3137125A1/en active Pending
- 2020-04-10 HR HRP20231619TT patent/HRP20231619T1/hr unknown
- 2020-04-10 AU AU2020263231A patent/AU2020263231A1/en active Pending
- 2020-04-10 PL PL20722197.9T patent/PL3958977T3/pl unknown
- 2020-04-10 JP JP2021563605A patent/JP2022529854A/ja active Pending
- 2020-04-10 CN CN202080031665.2A patent/CN113766954A/zh active Pending
- 2020-04-10 SG SG11202110922QA patent/SG11202110922QA/en unknown
- 2020-04-10 EP EP20722197.9A patent/EP3958977B1/en active Active
- 2020-04-10 KR KR1020217038788A patent/KR20220027828A/ko active Search and Examination
- 2020-04-10 EP EP23196776.1A patent/EP4316524A3/en active Pending
- 2020-04-10 LT LTEPPCT/US2020/027831T patent/LT3958977T/lt unknown
- 2020-04-10 DK DK20722197.9T patent/DK3958977T3/da active
- 2020-09-25 US US17/032,219 patent/US11229639B2/en active Active
-
2021
- 2021-09-30 IL IL286846A patent/IL286846A/en unknown
- 2021-10-15 US US17/502,806 patent/US20220133711A1/en active Pending
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