JPWO2020205409A5 - - Google Patents

Info

Publication number

JPWO2020205409A5

JPWO2020205409A5 JP2021559232A JP2021559232A JPWO2020205409A5 JP WO2020205409 A5 JPWO2020205409 A5 JP WO2020205409A5 JP 2021559232 A JP2021559232 A JP 2021559232A JP 2021559232 A JP2021559232 A JP 2021559232A JP WO2020205409 A5 JPWO2020205409 A5 JP WO2020205409A5

Authority

JP

Japan

Prior art keywords

composition

anion

cation

ionic liquid

acid

Prior art date

2023-03-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 24
• 150000001450 anions Chemical class 0.000 claims 18
• 150000001768 cations Chemical class 0.000 claims 13
• GJWSUKYXUMVMGX-UHFFFAOYSA-N citronellic acid Chemical compound OC(=O)CC(C)CCC=C(C)C GJWSUKYXUMVMGX-UHFFFAOYSA-N 0.000 claims 13
• 239000002608 ionic liquid Substances 0.000 claims 11
• 229930008398 Citronellate Natural products 0.000 claims 7
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 7
• 229960001231 choline Drugs 0.000 claims 7
• 150000001875 compounds Chemical class 0.000 claims 6
• WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
• 239000002253 acid Substances 0.000 claims 2
• OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 claims 2
• 239000002775 capsule Substances 0.000 claims 2
• ZHYZQXUYZJNEHD-VQHVLOKHSA-M geranate Chemical compound CC(C)=CCC\C(C)=C\C([O-])=O ZHYZQXUYZJNEHD-VQHVLOKHSA-M 0.000 claims 2
• ZHYZQXUYZJNEHD-VQHVLOKHSA-N geranic acid Chemical compound CC(C)=CCC\C(C)=C\C(O)=O ZHYZQXUYZJNEHD-VQHVLOKHSA-N 0.000 claims 2
• 229930008392 geranic acid Natural products 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 125000001453 quaternary ammonium group Chemical group 0.000 claims 2
• ZHYZQXUYZJNEHD-UHFFFAOYSA-N trans-geranic acid Natural products CC(C)=CCCC(C)=CC(O)=O ZHYZQXUYZJNEHD-UHFFFAOYSA-N 0.000 claims 2
• XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims 1
• 206010016654 Fibrosis Diseases 0.000 claims 1
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 239000002144 L01XE18 - Ruxolitinib Substances 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 208000025865 Ulcer Diseases 0.000 claims 1
• 229960002632 acarbose Drugs 0.000 claims 1
• XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims 1
• 150000001336 alkenes Chemical class 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 150000001735 carboxylic acids Chemical class 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000004761 fibrosis Effects 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 230000002601 intratumoral effect Effects 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 238000005016 nuclear Overhauser enhanced spectroscopy Methods 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
• -1 octenoate Chemical compound 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• HFNKQEVNSGCOJV-OAHLLOKOSA-N ruxolitinib Chemical compound C1([C@@H](CC#N)N2N=CC(=C2)C=2C=3C=CNC=3N=CN=2)CCCC1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 0.000 claims 1
• 229960000215 ruxolitinib Drugs 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• 231100000397 ulcer Toxicity 0.000 claims 1
• 230000004584 weight gain Effects 0.000 claims 1
• 235000019786 weight gain Nutrition 0.000 claims 1