JPWO2020188288A5 - - Google Patents

Info

Publication number

JPWO2020188288A5

JPWO2020188288A5 JP2022504738A JP2022504738A JPWO2020188288A5 JP WO2020188288 A5 JPWO2020188288 A5 JP WO2020188288A5 JP 2022504738 A JP2022504738 A JP 2022504738A JP 2022504738 A JP2022504738 A JP 2022504738A JP WO2020188288 A5 JPWO2020188288 A5 JP WO2020188288A5

Authority

JP

Japan

Prior art keywords

pain

compound

pharmaceutical composition

composition according

isomer

Prior art date

2023-03-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 208000002193 Pain Diseases 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 5
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
• 208000012902 Nervous system disease Diseases 0.000 claims 3
• 206010006002 Bone pain Diseases 0.000 claims 2
• 208000030886 Traumatic Brain injury Diseases 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 230000009529 traumatic brain injury Effects 0.000 claims 2
• 201000011452 Adrenoleukodystrophy Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 206010058019 Cancer Pain Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 206010012289 Dementia Diseases 0.000 claims 1
• 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
• 208000000059 Dyspnea Diseases 0.000 claims 1
• 206010013975 Dyspnoeas Diseases 0.000 claims 1
• 206010072132 Fracture pain Diseases 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• 208000001953 Hypotension Diseases 0.000 claims 1
• 206010021143 Hypoxia Diseases 0.000 claims 1
• 102000009030 Member 1 Subfamily D ATP Binding Cassette Transporter Human genes 0.000 claims 1
• 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 claims 1
• 201000009906 Meningitis Diseases 0.000 claims 1
• 208000000112 Myalgia Diseases 0.000 claims 1
• 208000005890 Neuroma Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 208000004983 Phantom Limb Diseases 0.000 claims 1
• 201000011252 Phenylketonuria Diseases 0.000 claims 1
• 102000002067 Protein Subunits Human genes 0.000 claims 1
• 108010001267 Protein Subunits Proteins 0.000 claims 1
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 230000036471 bradycardia Effects 0.000 claims 1
• 208000006218 bradycardia Diseases 0.000 claims 1
• 206010008129 cerebral palsy Diseases 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 230000002526 effect on cardiovascular system Effects 0.000 claims 1
• 206010014599 encephalitis Diseases 0.000 claims 1
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• 230000036543 hypotension Effects 0.000 claims 1
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• 230000002757 inflammatory effect Effects 0.000 claims 1
• 206010022437 insomnia Diseases 0.000 claims 1
• 208000028867 ischemia Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000012241 membrane hyperpolarization Effects 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 208000013465 muscle pain Diseases 0.000 claims 1
• 230000002981 neuropathic effect Effects 0.000 claims 1
• 230000003040 nociceptive effect Effects 0.000 claims 1
• 230000002093 peripheral effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 230000001242 postsynaptic effect Effects 0.000 claims 1
• 208000023504 respiratory system disease Diseases 0.000 claims 1
• 201000000980 schizophrenia Diseases 0.000 claims 1
• 208000019116 sleep disease Diseases 0.000 claims 1
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• 208000020431 spinal cord injury Diseases 0.000 claims 1
• 230000009278 visceral effect Effects 0.000 claims 1