JP2015526447A5 - - Google Patents
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- Publication number
- JP2015526447A5 JP2015526447A5 JP2015527749A JP2015527749A JP2015526447A5 JP 2015526447 A5 JP2015526447 A5 JP 2015526447A5 JP 2015527749 A JP2015527749 A JP 2015527749A JP 2015527749 A JP2015527749 A JP 2015527749A JP 2015526447 A5 JP2015526447 A5 JP 2015526447A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched alkyl
- linear
- pharmaceutically acceptable
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000004432 carbon atom Chemical group C* 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 230000004770 neurodegeneration Effects 0.000 claims 6
- 208000015122 neurodegenerative disease Diseases 0.000 claims 6
- 210000004556 brain Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000029483 Acquired immunodeficiency Diseases 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000003902 lesion Effects 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- CKYLCNCYPUJLOL-MOPGFXCFSA-N propan-2-yl (2r)-4-methyl-2-[[(3r)-4-(4-methylphenyl)sulfonylthiomorpholine-3-carbonyl]amino]pentanoate Chemical compound CC(C)OC(=O)[C@@H](CC(C)C)NC(=O)[C@@H]1CSCCN1S(=O)(=O)C1=CC=C(C)C=C1 CKYLCNCYPUJLOL-MOPGFXCFSA-N 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 230000000638 stimulation Effects 0.000 claims 2
- GFEHACHKMVZGNQ-CVEARBPZSA-N (2R)-4-methyl-2-[[(3R)-4-(4-methylphenyl)sulfonylthiomorpholine-3-carbonyl]amino]pentanoic acid Chemical compound CC(C[C@H](C(=O)O)NC(=O)[C@H]1N(CCSC1)S(=O)(=O)C1=CC=C(C=C1)C)C GFEHACHKMVZGNQ-CVEARBPZSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- KGLIRZRDGPAQQA-MSOLQXFVSA-N ethyl (2r)-4-methyl-2-[[(3r)-4-(4-methylphenyl)sulfonylthiomorpholine-3-carbonyl]amino]pentanoate Chemical compound CCOC(=O)[C@@H](CC(C)C)NC(=O)[C@@H]1CSCCN1S(=O)(=O)C1=CC=C(C)C=C1 KGLIRZRDGPAQQA-MSOLQXFVSA-N 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- WIKIRFYVGOETGS-MOPGFXCFSA-N propyl (2r)-4-methyl-2-[[(3r)-4-(4-methylphenyl)sulfonylthiomorpholine-3-carbonyl]amino]pentanoate Chemical compound CCCOC(=O)[C@@H](CC(C)C)NC(=O)[C@@H]1CSCCN1S(=O)(=O)C1=CC=C(C)C=C1 WIKIRFYVGOETGS-MOPGFXCFSA-N 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/080539 WO2014029102A1 (zh) | 2012-08-24 | 2012-08-24 | 噻嗪酰胺衍生物及其药物组合物和用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526447A JP2015526447A (ja) | 2015-09-10 |
| JP2015526447A5 true JP2015526447A5 (https=) | 2015-10-29 |
| JP6078153B2 JP6078153B2 (ja) | 2017-02-08 |
Family
ID=50149362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527749A Active JP6078153B2 (ja) | 2012-08-24 | 2012-08-24 | チアンジンアミド誘導体、並びにその医薬組成物及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9359314B2 (https=) |
| EP (1) | EP2889293B1 (https=) |
| JP (1) | JP6078153B2 (https=) |
| KR (1) | KR101899777B1 (https=) |
| CA (1) | CA2882289C (https=) |
| ES (1) | ES2629019T3 (https=) |
| WO (1) | WO2014029102A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106316982B (zh) * | 2015-06-30 | 2020-08-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻嗪酰胺衍生物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1173960C (zh) * | 2001-12-06 | 2004-11-03 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代六元氮杂环类化合物及其作为神经调节剂的用途 |
| US9623000B2 (en) * | 2008-07-31 | 2017-04-18 | Dekel Pharmaceuticals Ltd | Compositions and methods for treating inflammatory disorders |
| CN102675244B (zh) * | 2011-03-16 | 2016-03-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻嗪酰胺衍生物及其在制备神经退行性疾病防治药物的用途 |
-
2012
- 2012-08-24 ES ES12883262.3T patent/ES2629019T3/es active Active
- 2012-08-24 WO PCT/CN2012/080539 patent/WO2014029102A1/zh not_active Ceased
- 2012-08-24 CA CA2882289A patent/CA2882289C/en not_active Expired - Fee Related
- 2012-08-24 KR KR1020157007305A patent/KR101899777B1/ko active Active
- 2012-08-24 JP JP2015527749A patent/JP6078153B2/ja active Active
- 2012-08-24 US US14/423,205 patent/US9359314B2/en active Active
- 2012-08-24 EP EP12883262.3A patent/EP2889293B1/en active Active
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