JP2004532854A5 - - Google Patents

Info

Publication number

JP2004532854A5

JP2004532854A5 JP2002586941A JP2002586941A JP2004532854A5 JP 2004532854 A5 JP2004532854 A5 JP 2004532854A5 JP 2002586941 A JP2002586941 A JP 2002586941A JP 2002586941 A JP2002586941 A JP 2002586941A JP 2004532854 A5 JP2004532854 A5 JP 2004532854A5

Authority

JP

Japan

Prior art keywords

pharmaceutically acceptable

acceptable salt

substituted

solvate

prodrug

Prior art date

2002-05-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

• 150000003839 salts Chemical class 0.000 claims 25
• -1 dimethoxymethyl Chemical group 0.000 claims 24
• 239000012453 solvate Substances 0.000 claims 21
• 150000001875 compounds Chemical class 0.000 claims 19
• 239000002207 metabolite Substances 0.000 claims 19
• 125000000217 alkyl group Chemical group 0.000 claims 17
• 239000000651 prodrug Substances 0.000 claims 15
• 229940002612 prodrug Drugs 0.000 claims 15
• 229910052739 hydrogen Inorganic materials 0.000 claims 14
• 239000001257 hydrogen Substances 0.000 claims 14
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 8
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 7
• 229910052799 carbon Inorganic materials 0.000 claims 7
• 125000001072 heteroaryl group Chemical group 0.000 claims 7
• 239000001301 oxygen Substances 0.000 claims 7
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
• 125000000753 cycloalkyl group Chemical group 0.000 claims 6
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
• 229910052757 nitrogen Inorganic materials 0.000 claims 6
• 125000003118 aryl group Chemical group 0.000 claims 5
• 150000002431 hydrogen Chemical class 0.000 claims 5
• 208000012902 Nervous system disease Diseases 0.000 claims 4
• 125000003342 alkenyl group Chemical group 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
• 230000006378 damage Effects 0.000 claims 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 claims 2
• 125000002252 acyl group Chemical group 0.000 claims 2
• 150000001412 amines Chemical class 0.000 claims 2
• 125000004429 atom Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
• ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
• 150000004820 halides Chemical class 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 2
• 201000001119 neuropathy Diseases 0.000 claims 2
• 230000007823 neuropathy Effects 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• 208000033808 peripheral neuropathy Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
• 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 claims 1
• 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 claims 1
• 125000004361 3,4,5-trifluorophenyl group Chemical group [H]C1=C(F)C(F)=C(F)C([H])=C1* 0.000 claims 1
• 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 1
• 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 claims 1
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
• 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 1
• 125000004801 4-cyanophenyl group Chemical group [H]C1=C([H])C(C#N)=C([H])C([H])=C1* 0.000 claims 1
• 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
• 201000004384 Alopecia Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 206010011878 Deafness Diseases 0.000 claims 1
• GMPKIPWJBDOURN-UHFFFAOYSA-N Methoxyamine Chemical compound CON GMPKIPWJBDOURN-UHFFFAOYSA-N 0.000 claims 1
• 108010025020 Nerve Growth Factor Proteins 0.000 claims 1
• 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
• 208000025966 Neurological disease Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 206010047571 Visual impairment Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 231100000360 alopecia Toxicity 0.000 claims 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
• 235000010290 biphenyl Nutrition 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 230000006931 brain damage Effects 0.000 claims 1
• 231100000874 brain damage Toxicity 0.000 claims 1
• 208000029028 brain injury Diseases 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 230000010370 hearing loss Effects 0.000 claims 1
• 231100000888 hearing loss Toxicity 0.000 claims 1
• 208000016354 hearing loss disease Diseases 0.000 claims 1
• 208000014674 injury Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 206010027175 memory impairment Diseases 0.000 claims 1
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 230000004770 neurodegeneration Effects 0.000 claims 1
• 239000003900 neurotrophic factor Substances 0.000 claims 1
• 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
• 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 210000000278 spinal cord Anatomy 0.000 claims 1
• 208000029257 vision disease Diseases 0.000 claims 1
• 230000004393 visual impairment Effects 0.000 claims 1