JPWO2020183245A5 - - Google Patents

Info

Publication number

JPWO2020183245A5

JPWO2020183245A5 JP2021553382A JP2021553382A JPWO2020183245A5 JP WO2020183245 A5 JPWO2020183245 A5 JP WO2020183245A5 JP 2021553382 A JP2021553382 A JP 2021553382A JP 2021553382 A JP2021553382 A JP 2021553382A JP WO2020183245 A5 JPWO2020183245 A5 JP WO2020183245A5

Authority

JP

Japan

Prior art keywords

antigen

binding fragment

bispecific antibody

seq

isolated

Prior art date

2023-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000427 antigen Substances 0.000 claims description 96
• 102000036639 antigens Human genes 0.000 claims description 96
• 108091007433 antigens Proteins 0.000 claims description 96
• 239000012634 fragment Substances 0.000 claims description 82
• 210000004027 cell Anatomy 0.000 claims description 33
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
• 206010028980 Neoplasm Diseases 0.000 claims description 21
• 201000011510 cancer Diseases 0.000 claims description 19
• 150000007523 nucleic acids Chemical class 0.000 claims description 16
• 102000039446 nucleic acids Human genes 0.000 claims description 16
• 108020004707 nucleic acids Proteins 0.000 claims description 16
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 13
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
• 238000000034 method Methods 0.000 claims description 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 238000012258 culturing Methods 0.000 claims description 4
• 230000003013 cytotoxicity Effects 0.000 claims description 4
• 231100000135 cytotoxicity Toxicity 0.000 claims description 4
• 230000001419 dependent effect Effects 0.000 claims description 4
• 238000000338 in vitro Methods 0.000 claims description 4
• 238000004806 packaging method and process Methods 0.000 claims description 4
• 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
• 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• 210000000130 stem cell Anatomy 0.000 claims description 2
• 230000008685 targeting Effects 0.000 claims description 2
• 230000010261 cell growth Effects 0.000 claims 1
• 230000004663 cell proliferation Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2