JPWO2020169736A5 - - Google Patents
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- JPWO2020169736A5 JPWO2020169736A5 JP2021549407A JP2021549407A JPWO2020169736A5 JP WO2020169736 A5 JPWO2020169736 A5 JP WO2020169736A5 JP 2021549407 A JP2021549407 A JP 2021549407A JP 2021549407 A JP2021549407 A JP 2021549407A JP WO2020169736 A5 JPWO2020169736 A5 JP WO2020169736A5
- Authority
- JP
- Japan
- Prior art keywords
- crystalline form
- temperature
- syndrome
- disorder
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 201000010099 disease Diseases 0.000 claims description 14
- 208000011580 syndromic disease Diseases 0.000 claims description 14
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 12
- 229940126062 Compound A Drugs 0.000 claims description 10
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 101150113681 MALT1 gene Proteins 0.000 claims description 6
- 102000057613 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Human genes 0.000 claims description 6
- 108700026676 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Proteins 0.000 claims description 6
- 230000005764 inhibitory process Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000002244 precipitate Substances 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000010899 nucleation Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- APWRZPQBPCAXFP-UHFFFAOYSA-N 1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]pyrazole-4-carboxamide Chemical compound O=C1NC=CC2=C(C=CC=C12)N1N=CC(=C1C(F)(F)F)C(=O)NC1=CC(=NC=C1)C(F)(F)F APWRZPQBPCAXFP-UHFFFAOYSA-N 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000013078 crystal Substances 0.000 claims description 2
- 238000000113 differential scanning calorimetry Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- -1 elixir Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 150000004682 monohydrates Chemical class 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 238000001757 thermogravimetry curve Methods 0.000 claims description 2
- 230000000877 morphologic effect Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019075834 | 2019-02-22 | ||
| CNPCT/CN2019/075834 | 2019-02-22 | ||
| PCT/EP2020/054485 WO2020169736A1 (en) | 2019-02-22 | 2020-02-20 | Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-n-(2-(trifluoromethyl)pyridin-4-yl)-1h-pyrazole-4-carboxamide monohydrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022523368A JP2022523368A (ja) | 2022-04-22 |
| JPWO2020169736A5 true JPWO2020169736A5 (enExample) | 2023-02-28 |
Family
ID=69723907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021549407A Pending JP2022523368A (ja) | 2019-02-22 | 2020-02-20 | １－（１－オキソ－１，２－ジヒドロイソキノリン－５－イル）－５－（トリフルオロメチル）－ｎ－［２－（トリフルオロメチル）ピリジン－４－イル］－１ｈ－ピラゾール－４－カルボキサミド一水和物の結晶形態 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12269813B2 (enExample) |
| EP (1) | EP3927696B1 (enExample) |
| JP (1) | JP2022523368A (enExample) |
| KR (1) | KR20210131371A (enExample) |
| CN (1) | CN113474339B (enExample) |
| AU (1) | AU2020226723B2 (enExample) |
| BR (1) | BR112021016400A2 (enExample) |
| CA (1) | CA3129623A1 (enExample) |
| EA (1) | EA202192320A1 (enExample) |
| EC (1) | ECSP21067828A (enExample) |
| ES (1) | ES2966132T3 (enExample) |
| IL (1) | IL285675A (enExample) |
| JO (1) | JOP20210227A1 (enExample) |
| MA (1) | MA55019A (enExample) |
| MX (1) | MX2021010133A (enExample) |
| PE (1) | PE20212067A1 (enExample) |
| PH (1) | PH12021552018A1 (enExample) |
| SG (1) | SG11202108909SA (enExample) |
| TW (1) | TW202045495A (enExample) |
| UY (1) | UY38592A (enExample) |
| WO (1) | WO2020169736A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| US12404260B2 (en) | 2019-04-11 | 2025-09-02 | Janssen Pharmaceutica Nv | Pyridine rings containing derivatives as MALT1 inhibitors |
| BR112023003106A2 (pt) | 2020-08-21 | 2023-04-04 | Janssen Pharmaceutica Nv | Forma amorfa de um inibidor de malt1 e formulações do mesmo |
| BR112023017689A2 (pt) | 2021-03-03 | 2023-11-14 | Janssen Pharmaceutica Nv | Método de tratamento de uma condição com o uso de uma dose terapeuticamente eficaz do inibidor de malt1 jnj-67856633 (1-(1-oxo-1,2-di-hidroisoquinolin-5-il)-5-(trifluorometil)-n(2-(trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida) |
| EP4301365A1 (en) | 2021-03-03 | 2024-01-10 | Janssen Pharmaceutica NV | Combination therapy using a malt1 inhibitor and a btk inhibitor |
| AU2022326183A1 (en) * | 2021-08-09 | 2024-03-28 | Janssen Pharmaceutica Nv | Compositions for use in treating b-cell malignancies |
| WO2025073968A1 (en) | 2023-10-06 | 2025-04-10 | Ionctura Sa | Combination of roginolisib with a malt1-gls inhibitor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007525183A (ja) | 2003-04-30 | 2007-09-06 | アジェンシス， インコーポレイテッド | 癌の処置および検出において有用な１０９ｐ１ｄ４と称される、核酸および対応タンパク質 |
| WO2007111904A2 (en) * | 2006-03-22 | 2007-10-04 | Vertex Pharmaceuticals Incorporated | C-met protein kinase inhibitors for the treatment of proliferative disorders |
| WO2008092292A1 (en) | 2007-01-17 | 2008-08-07 | The Hong Kong University Of Science And Technology | Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2 |
| WO2011036885A1 (ja) * | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| US20120071497A1 (en) | 2010-06-03 | 2012-03-22 | Pharmacyclics, Inc. | Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase |
| KR101580714B1 (ko) | 2010-06-03 | 2016-01-04 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 인산화효소(ｂｔｋ)의 억제제의 용도 |
| CN102947270B (zh) | 2010-06-22 | 2015-04-08 | 巴斯夫欧洲公司 | 制备4-羟基吡啶的方法 |
| MX2014014531A (es) * | 2012-05-31 | 2015-04-08 | Hoffmann La Roche | Derivados de aminoquinazolina y piridopirimidina. |
| HUE044351T2 (hu) | 2014-05-28 | 2019-10-28 | Novartis Ag | Új pirazolo-pirimidin származékok és azok alkalmazása MALT1 inhibitorként |
| EP3177366A4 (en) | 2014-08-08 | 2018-04-04 | Pharmacyclics LLC | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
| US10835524B2 (en) * | 2015-06-24 | 2020-11-17 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of pancreatic cancer and uses thereof |
| CA3003820A1 (en) | 2015-11-13 | 2017-05-18 | Novartis Ag | Novel pyrazolo pyrimidine derivatives |
| EP3423452B1 (en) | 2016-03-01 | 2025-05-07 | University of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| TWI795381B (zh) * | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| EP3576744A1 (en) | 2017-02-01 | 2019-12-11 | Medivir Aktiebolag | Therapeutic applications of malt1 inhibitors |
| US11571427B2 (en) | 2017-12-28 | 2023-02-07 | The General Hospital Corporation | Targeting the CBM signalosome complex induces regulatory T cells to inflame the tumor microenvironment |
| WO2019161921A1 (de) | 2018-02-23 | 2019-08-29 | Industrieanlagen-Betriebsgesellschaft Mbh | Vorrichtung zum erzeugen eines magnetfelds, insbesondere für ein induktives ladesystem, und primäreinrichtung eines induktiven ladesystems zum dynamischen aufladen von fahrzeugen |
| WO2021138298A1 (en) | 2019-12-30 | 2021-07-08 | Rheos Medicines, Inc. | Malt1 modulators and uses thereof |
| BR112023003106A2 (pt) * | 2020-08-21 | 2023-04-04 | Janssen Pharmaceutica Nv | Forma amorfa de um inibidor de malt1 e formulações do mesmo |
-
2020
- 2020-02-20 AU AU2020226723A patent/AU2020226723B2/en not_active Expired - Fee Related
- 2020-02-20 SG SG11202108909SA patent/SG11202108909SA/en unknown
- 2020-02-20 JO JOP/2021/0227A patent/JOP20210227A1/ar unknown
- 2020-02-20 EP EP20707585.4A patent/EP3927696B1/en active Active
- 2020-02-20 EA EA202192320A patent/EA202192320A1/ru unknown
- 2020-02-20 KR KR1020217029765A patent/KR20210131371A/ko not_active Withdrawn
- 2020-02-20 WO PCT/EP2020/054485 patent/WO2020169736A1/en not_active Ceased
- 2020-02-20 MA MA055019A patent/MA55019A/fr unknown
- 2020-02-20 PH PH1/2021/552018A patent/PH12021552018A1/en unknown
- 2020-02-20 CN CN202080015968.5A patent/CN113474339B/zh active Active
- 2020-02-20 US US17/431,447 patent/US12269813B2/en active Active
- 2020-02-20 PE PE2021001372A patent/PE20212067A1/es unknown
- 2020-02-20 CA CA3129623A patent/CA3129623A1/en active Pending
- 2020-02-20 ES ES20707585T patent/ES2966132T3/es active Active
- 2020-02-20 JP JP2021549407A patent/JP2022523368A/ja active Pending
- 2020-02-20 MX MX2021010133A patent/MX2021010133A/es unknown
- 2020-02-20 BR BR112021016400-6A patent/BR112021016400A2/pt not_active Application Discontinuation
- 2020-02-21 UY UY0001038592A patent/UY38592A/es unknown
- 2020-02-21 TW TW109105620A patent/TW202045495A/zh unknown
-
2021
- 2021-08-17 IL IL285675A patent/IL285675A/en unknown
- 2021-09-14 EC ECSENADI202167828A patent/ECSP21067828A/es unknown
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