JPWO2020158832A1 - - Google Patents

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Publication number
JPWO2020158832A1
JPWO2020158832A1 JP2020569703A JP2020569703A JPWO2020158832A1 JP WO2020158832 A1 JPWO2020158832 A1 JP WO2020158832A1 JP 2020569703 A JP2020569703 A JP 2020569703A JP 2020569703 A JP2020569703 A JP 2020569703A JP WO2020158832 A1 JPWO2020158832 A1 JP WO2020158832A1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020569703A
Other languages
Japanese (ja)
Other versions
JPWO2020158832A5 (https=
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPWO2020158832A1 publication Critical patent/JPWO2020158832A1/ja
Publication of JPWO2020158832A5 publication Critical patent/JPWO2020158832A5/ja
Priority to JP2024062470A priority Critical patent/JP7788174B2/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0845—Filaments, strings, fibres, i.e. not hollow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0858—Side walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0896—Nanoscaled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Biomedical Technology (AREA)
  • Fluid Mechanics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2020569703A 2019-01-30 2020-01-29 Pending JPWO2020158832A1 (https=)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024062470A JP7788174B2 (ja) 2019-01-30 2024-04-09 生体分子回収デバイス並びに方法、生体分子分析デバイス並びに方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019014906 2019-01-30
PCT/JP2020/003284 WO2020158832A1 (ja) 2019-01-30 2020-01-29 生体分子回収デバイス並びに方法、生体分子分析デバイス並びに方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024062470A Division JP7788174B2 (ja) 2019-01-30 2024-04-09 生体分子回収デバイス並びに方法、生体分子分析デバイス並びに方法

Publications (2)

Publication Number Publication Date
JPWO2020158832A1 true JPWO2020158832A1 (https=) 2020-08-06
JPWO2020158832A5 JPWO2020158832A5 (https=) 2023-02-03

Family

ID=71841347

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020569703A Pending JPWO2020158832A1 (https=) 2019-01-30 2020-01-29
JP2024062470A Active JP7788174B2 (ja) 2019-01-30 2024-04-09 生体分子回収デバイス並びに方法、生体分子分析デバイス並びに方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024062470A Active JP7788174B2 (ja) 2019-01-30 2024-04-09 生体分子回収デバイス並びに方法、生体分子分析デバイス並びに方法

Country Status (5)

Country Link
US (1) US20220143613A1 (https=)
EP (1) EP3919917B1 (https=)
JP (2) JPWO2020158832A1 (https=)
CN (1) CN113597559A (https=)
WO (1) WO2020158832A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020092688A (ja) 2018-12-12 2020-06-18 国立大学法人東海国立大学機構 マイクロｒｎａを含む体液抽出物
JP7195538B2 (ja) * 2019-03-15 2022-12-26 国立大学法人東海国立大学機構 デバイスの製造方法、および、デバイス
EP4029940A4 (en) * 2019-09-09 2024-02-28 Craif Inc. Body fluid extract containing micro rna
WO2022059762A1 (ja) * 2020-09-18 2022-03-24 国立大学法人東海国立大学機構 生体分子の抽出方法
CN115318349B (zh) * 2022-08-11 2024-10-18 华中科技大学 集成二氧化钛纳米材料微流控芯片及制备与应用

Citations (9)

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JP2008275523A (ja) * 2007-05-01 2008-11-13 Matsushita Electric Ind Co Ltd 液体試料分析装置
JP2009187025A (ja) * 2002-10-30 2009-08-20 Hitachi Ltd 柱状微小突起群を備えた機能性基板とその製造方法
JP5171812B2 (ja) * 2006-04-27 2013-03-27 ユニベルシテ ドゥ モントリオール 移植片対宿主病のリスクの評価および低減
US20130225416A1 (en) * 2011-11-29 2013-08-29 Gabriela Altmann Electronic sequencing
JP5637953B2 (ja) * 2011-07-26 2014-12-10 株式会社日立ハイテクノロジーズ 核酸分析用反応デバイス
WO2015137427A1 (ja) * 2014-03-12 2015-09-17 国立大学法人名古屋大学 生体分子抽出用チップ、及び生体分子抽出用チップの製造方法
CN107085107A (zh) * 2017-04-17 2017-08-22 无锡准因生物科技有限公司 一种检测食管鳞状细胞癌循环肿瘤细胞的微流体系统及其应用
WO2017154614A1 (ja) * 2016-03-09 2017-09-14 国立大学法人名古屋大学 ナノワイヤデバイス、該ナノワイヤデバイスを含む分析装置、サンプルの加熱処理方法及びサンプルの分離方法
JP2017203763A (ja) * 2016-05-09 2017-11-16 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法

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US7290667B1 (en) * 2002-07-03 2007-11-06 The Regents Of The University Of California Microfluidic sieve using intertwined, free-standing carbon nanotube mesh as active medium
FR2885898B1 (fr) * 2005-05-17 2007-07-06 Commissariat Energie Atomique Composant microfluidique comprenant au moins un canal rempli de nanotubes et procede de fabrication d'un tel composant microfluidique.
JP2007155398A (ja) * 2005-12-01 2007-06-21 Canon Inc 濃縮素子、及び、それを用いた化学分析装置
US8813777B2 (en) * 2007-04-17 2014-08-26 Nxp, B.V. Fluid separation structure and a method of manufacturing a fluid separation structure
DE102008015333B4 (de) * 2008-03-20 2021-05-12 Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh Nanodraht-Strukturelement, Verfahren zu dessen Herstellung, Mikroreaktorsystem und Katalysatorsystem
FR2930900B1 (fr) * 2008-05-06 2010-09-10 Commissariat Energie Atomique Dispositif de separation de biomolecules d'un fluide
WO2012129527A2 (en) * 2011-03-24 2012-09-27 Cornell University Biofunctional nanofibers for analyte separation in microchannels
US9139416B2 (en) * 2012-08-01 2015-09-22 University Of South Carolina Microfluidic devices for the generation of nano-vapor bubbles and their methods of manufacture and use
JP6181562B2 (ja) * 2014-01-20 2017-08-16 グンゼ株式会社 下半身用衣類
TWI635041B (zh) * 2017-06-09 2018-09-11 國立臺灣師範大學 微流道晶片及其製作方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009187025A (ja) * 2002-10-30 2009-08-20 Hitachi Ltd 柱状微小突起群を備えた機能性基板とその製造方法
JP5171812B2 (ja) * 2006-04-27 2013-03-27 ユニベルシテ ドゥ モントリオール 移植片対宿主病のリスクの評価および低減
JP2008275523A (ja) * 2007-05-01 2008-11-13 Matsushita Electric Ind Co Ltd 液体試料分析装置
JP5637953B2 (ja) * 2011-07-26 2014-12-10 株式会社日立ハイテクノロジーズ 核酸分析用反応デバイス
US20130225416A1 (en) * 2011-11-29 2013-08-29 Gabriela Altmann Electronic sequencing
WO2015137427A1 (ja) * 2014-03-12 2015-09-17 国立大学法人名古屋大学 生体分子抽出用チップ、及び生体分子抽出用チップの製造方法
WO2017154614A1 (ja) * 2016-03-09 2017-09-14 国立大学法人名古屋大学 ナノワイヤデバイス、該ナノワイヤデバイスを含む分析装置、サンプルの加熱処理方法及びサンプルの分離方法
JP2017203763A (ja) * 2016-05-09 2017-11-16 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
CN107085107A (zh) * 2017-04-17 2017-08-22 无锡准因生物科技有限公司 一种检测食管鳞状细胞癌循环肿瘤细胞的微流体系统及其应用

Also Published As

Publication number Publication date
JP7788174B2 (ja) 2025-12-18
EP3919917A4 (en) 2022-11-02
EP3919917B1 (en) 2025-09-17
CN113597559A (zh) 2021-11-02
EP3919917C0 (en) 2025-09-17
WO2020158832A1 (ja) 2020-08-06
US20220143613A1 (en) 2022-05-12
EP3919917A1 (en) 2021-12-08
JP2024088754A (ja) 2024-07-02

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