JPWO2020150439A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020150439A5 JPWO2020150439A5 JP2021541215A JP2021541215A JPWO2020150439A5 JP WO2020150439 A5 JPWO2020150439 A5 JP WO2020150439A5 JP 2021541215 A JP2021541215 A JP 2021541215A JP 2021541215 A JP2021541215 A JP 2021541215A JP WO2020150439 A5 JPWO2020150439 A5 JP WO2020150439A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently selected
- optionally substituted
- ring
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 183
- 229910052757 nitrogen Inorganic materials 0.000 claims description 144
- 125000006413 ring segment Chemical group 0.000 claims description 131
- 229910020008 S(O) Inorganic materials 0.000 claims description 116
- 125000005842 heteroatom Chemical group 0.000 claims description 109
- 150000001875 compounds Chemical class 0.000 claims description 108
- 125000001072 heteroaryl group Chemical group 0.000 claims description 83
- 229910052760 oxygen Inorganic materials 0.000 claims description 76
- 125000005843 halogen group Chemical group 0.000 claims description 46
- 229910052799 carbon Inorganic materials 0.000 claims description 44
- 125000000623 heterocyclic group Chemical group 0.000 claims description 38
- 229910052717 sulfur Inorganic materials 0.000 claims description 38
- 125000003545 alkoxy group Chemical group 0.000 claims description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 31
- 125000003118 aryl group Chemical group 0.000 claims description 29
- 125000004432 carbon atom Chemical group C* 0.000 claims description 29
- 125000001424 substituent group Chemical group 0.000 claims description 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 26
- 125000002947 alkylene group Chemical group 0.000 claims description 20
- 201000010099 disease Diseases 0.000 claims description 20
- -1 —OH Chemical group 0.000 claims description 20
- 150000001721 carbon Chemical group 0.000 claims description 17
- 125000005309 thioalkoxy group Chemical group 0.000 claims description 13
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims description 11
- 125000002619 bicyclic group Chemical group 0.000 claims description 11
- 208000035475 disorder Diseases 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 230000011664 signaling Effects 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- 125000002837 carbocyclic group Chemical group 0.000 claims description 3
- 230000007170 pathology Effects 0.000 claims description 3
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 6
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 1
- 125000006651 (C3-C20) cycloalkyl group Chemical group 0.000 claims 1
- 101100277337 Arabidopsis thaliana DDM1 gene Proteins 0.000 claims 1
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 claims 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 claims 1
- 101150113676 chr1 gene Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 155
- 125000001188 haloalkyl group Chemical group 0.000 description 20
- 206010028980 Neoplasm Diseases 0.000 description 19
- 125000004438 haloalkoxy group Chemical group 0.000 description 17
- 239000003446 ligand Substances 0.000 description 16
- 201000011510 cancer Diseases 0.000 description 15
- 125000000753 cycloalkyl group Chemical group 0.000 description 14
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 12
- 101000884270 Homo sapiens Natural killer cell receptor 2B4 Proteins 0.000 description 12
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 description 12
- 101710183280 Topoisomerase Proteins 0.000 description 12
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 11
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 10
- 206010044412 transitional cell carcinoma Diseases 0.000 description 10
- 206010009944 Colon cancer Diseases 0.000 description 9
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 9
- 108010074708 B7-H1 Antigen Proteins 0.000 description 8
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 8
- 229940045513 CTLA4 antagonist Drugs 0.000 description 8
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 8
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 8
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 8
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 8
- 102000037978 Immune checkpoint receptors Human genes 0.000 description 8
- 108091008028 Immune checkpoint receptors Proteins 0.000 description 8
- 102000000588 Interleukin-2 Human genes 0.000 description 8
- 108010002350 Interleukin-2 Proteins 0.000 description 8
- 101710092458 Lymphocyte activation gene 3 protein Proteins 0.000 description 8
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 description 8
- 229930012538 Paclitaxel Natural products 0.000 description 8
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 8
- 102100040678 Programmed cell death protein 1 Human genes 0.000 description 8
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 8
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 8
- 239000002246 antineoplastic agent Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000002512 chemotherapy Methods 0.000 description 8
- 229940127089 cytotoxic agent Drugs 0.000 description 8
- 229960001743 golimumab Drugs 0.000 description 8
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 description 8
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 description 8
- 238000011275 oncology therapy Methods 0.000 description 8
- 229960001592 paclitaxel Drugs 0.000 description 8
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 8
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 7
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 7
- 238000011282 treatment Methods 0.000 description 6
- 206010005003 Bladder cancer Diseases 0.000 description 5
- 206010006187 Breast cancer Diseases 0.000 description 5
- 208000026310 Breast neoplasm Diseases 0.000 description 5
- 206010008342 Cervix carcinoma Diseases 0.000 description 5
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 5
- 206010062878 Gastrooesophageal cancer Diseases 0.000 description 5
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 5
- 208000008839 Kidney Neoplasms Diseases 0.000 description 5
- 206010025323 Lymphomas Diseases 0.000 description 5
- 208000034578 Multiple myelomas Diseases 0.000 description 5
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 5
- 206010029260 Neuroblastoma Diseases 0.000 description 5
- 206010033128 Ovarian cancer Diseases 0.000 description 5
- 206010061535 Ovarian neoplasm Diseases 0.000 description 5
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 5
- 206010035226 Plasma cell myeloma Diseases 0.000 description 5
- 206010060862 Prostate cancer Diseases 0.000 description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 5
- 206010038389 Renal cancer Diseases 0.000 description 5
- 206010039491 Sarcoma Diseases 0.000 description 5
- 206010041067 Small cell lung cancer Diseases 0.000 description 5
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 5
- 208000024313 Testicular Neoplasms Diseases 0.000 description 5
- 206010057644 Testis cancer Diseases 0.000 description 5
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 5
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 5
- 208000008383 Wilms tumor Diseases 0.000 description 5
- 201000010881 cervical cancer Diseases 0.000 description 5
- 201000006974 gastroesophageal cancer Diseases 0.000 description 5
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 description 5
- 201000010982 kidney cancer Diseases 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 208000006178 malignant mesothelioma Diseases 0.000 description 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 5
- 201000001441 melanoma Diseases 0.000 description 5
- 125000002950 monocyclic group Chemical group 0.000 description 5
- 201000008026 nephroblastoma Diseases 0.000 description 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 5
- 201000002528 pancreatic cancer Diseases 0.000 description 5
- 208000008443 pancreatic carcinoma Diseases 0.000 description 5
- 208000010626 plasma cell neoplasm Diseases 0.000 description 5
- 208000000587 small cell lung carcinoma Diseases 0.000 description 5
- 201000003120 testicular cancer Diseases 0.000 description 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 5
- 201000005112 urinary bladder cancer Diseases 0.000 description 5
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 4
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 4
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 4
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 4
- 102100022464 5'-nucleotidase Human genes 0.000 description 4
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 4
- 108010006654 Bleomycin Proteins 0.000 description 4
- 102100025429 Butyrophilin-like protein 2 Human genes 0.000 description 4
- 108010017533 Butyrophilins Proteins 0.000 description 4
- 102000004555 Butyrophilins Human genes 0.000 description 4
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 4
- 102100024263 CD160 antigen Human genes 0.000 description 4
- 102100027207 CD27 antigen Human genes 0.000 description 4
- 102100038078 CD276 antigen Human genes 0.000 description 4
- 101710185679 CD276 antigen Proteins 0.000 description 4
- 108010029697 CD40 Ligand Proteins 0.000 description 4
- 102100032937 CD40 ligand Human genes 0.000 description 4
- 102100029382 CMRF35-like molecule 6 Human genes 0.000 description 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 108010092160 Dactinomycin Proteins 0.000 description 4
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 description 4
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 4
- 108700012941 GNRH1 Proteins 0.000 description 4
- 102000007563 Galectins Human genes 0.000 description 4
- 108010046569 Galectins Proteins 0.000 description 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 4
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 4
- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 4
- 108010069236 Goserelin Proteins 0.000 description 4
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 description 4
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 description 4
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 description 4
- 101000934738 Homo sapiens Butyrophilin-like protein 2 Proteins 0.000 description 4
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 description 4
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 4
- 101000990034 Homo sapiens CMRF35-like molecule 6 Proteins 0.000 description 4
- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 description 4
- 101000991061 Homo sapiens MHC class I polypeptide-related sequence B Proteins 0.000 description 4
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 4
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 4
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 description 4
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 description 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 4
- 101000764622 Homo sapiens Transmembrane and immunoglobulin domain-containing protein 2 Proteins 0.000 description 4
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 description 4
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 4
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 description 4
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 4
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 4
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 description 4
- 108060003951 Immunoglobulin Proteins 0.000 description 4
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 description 4
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 description 4
- 108020003285 Isocitrate lyase Proteins 0.000 description 4
- 101150069255 KLRC1 gene Proteins 0.000 description 4
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 description 4
- 102100030300 MHC class I polypeptide-related sequence B Human genes 0.000 description 4
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 description 4
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 description 4
- 229930192392 Mitomycin Natural products 0.000 description 4
- 108010008701 Mucin-3 Proteins 0.000 description 4
- 102000007295 Mucin-3 Human genes 0.000 description 4
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 4
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 description 4
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 4
- 102000002111 Neuropilin Human genes 0.000 description 4
- 108050009450 Neuropilin Proteins 0.000 description 4
- 101150012848 PVR gene Proteins 0.000 description 4
- 102100029740 Poliovirus receptor Human genes 0.000 description 4
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 4
- 206010070308 Refractory cancer Diseases 0.000 description 4
- 102000007073 Sialic Acid Binding Immunoglobulin-like Lectins Human genes 0.000 description 4
- 108010047827 Sialic Acid Binding Immunoglobulin-like Lectins Proteins 0.000 description 4
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 description 4
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 4
- 229940123237 Taxane Drugs 0.000 description 4
- 102100026224 Transmembrane and immunoglobulin domain-containing protein 2 Human genes 0.000 description 4
- 108010050144 Triptorelin Pamoate Proteins 0.000 description 4
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 4
- 102100022203 Tumor necrosis factor receptor superfamily member 25 Human genes 0.000 description 4
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 4
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 description 4
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 description 4
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 description 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 4
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 4
- 229940122803 Vinca alkaloid Drugs 0.000 description 4
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 description 4
- 229960000446 abciximab Drugs 0.000 description 4
- 229930183665 actinomycin Natural products 0.000 description 4
- 229960002964 adalimumab Drugs 0.000 description 4
- 208000009956 adenocarcinoma Diseases 0.000 description 4
- 229960005305 adenosine Drugs 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 229960000548 alemtuzumab Drugs 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 229940100198 alkylating agent Drugs 0.000 description 4
- 239000002168 alkylating agent Substances 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 4
- 229960001220 amsacrine Drugs 0.000 description 4
- 239000004037 angiogenesis inhibitor Substances 0.000 description 4
- 239000000921 anthelmintic agent Substances 0.000 description 4
- 229940045799 anthracyclines and related substance Drugs 0.000 description 4
- 230000000340 anti-metabolite Effects 0.000 description 4
- 230000001028 anti-proliverative effect Effects 0.000 description 4
- 229940100197 antimetabolite Drugs 0.000 description 4
- 239000002256 antimetabolite Substances 0.000 description 4
- 239000003972 antineoplastic antibiotic Substances 0.000 description 4
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 4
- 229960002170 azathioprine Drugs 0.000 description 4
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 4
- 229960004669 basiliximab Drugs 0.000 description 4
- 229960003270 belimumab Drugs 0.000 description 4
- 229960000397 bevacizumab Drugs 0.000 description 4
- 229960000997 bicalutamide Drugs 0.000 description 4
- 229960001561 bleomycin Drugs 0.000 description 4
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 4
- 229960001838 canakinumab Drugs 0.000 description 4
- 229960004562 carboplatin Drugs 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 229960003115 certolizumab pegol Drugs 0.000 description 4
- 229960005395 cetuximab Drugs 0.000 description 4
- 229960004630 chlorambucil Drugs 0.000 description 4
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 4
- 229960004316 cisplatin Drugs 0.000 description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 4
- 238000000315 cryotherapy Methods 0.000 description 4
- 229960004397 cyclophosphamide Drugs 0.000 description 4
- 229960002806 daclizumab Drugs 0.000 description 4
- 229960000975 daunorubicin Drugs 0.000 description 4
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 4
- 229960001251 denosumab Drugs 0.000 description 4
- 229960003668 docetaxel Drugs 0.000 description 4
- 229960004679 doxorubicin Drugs 0.000 description 4
- 229960002224 eculizumab Drugs 0.000 description 4
- 229960000284 efalizumab Drugs 0.000 description 4
- 229960001904 epirubicin Drugs 0.000 description 4
- 229960005420 etoposide Drugs 0.000 description 4
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 4
- LIQODXNTTZAGID-OCBXBXKTSA-N etoposide phosphate Chemical compound COC1=C(OP(O)(O)=O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 LIQODXNTTZAGID-OCBXBXKTSA-N 0.000 description 4
- 229960000752 etoposide phosphate Drugs 0.000 description 4
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 description 4
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 4
- 229960002074 flutamide Drugs 0.000 description 4
- 229960000578 gemtuzumab Drugs 0.000 description 4
- 238000001415 gene therapy Methods 0.000 description 4
- 229960002913 goserelin Drugs 0.000 description 4
- HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 description 4
- 108700020746 histrelin Proteins 0.000 description 4
- 229960002193 histrelin Drugs 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 229960001001 ibritumomab tiuxetan Drugs 0.000 description 4
- 229960000908 idarubicin Drugs 0.000 description 4
- 229960001101 ifosfamide Drugs 0.000 description 4
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 4
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 description 4
- 102000018358 immunoglobulin Human genes 0.000 description 4
- 238000009169 immunotherapy Methods 0.000 description 4
- 229960000598 infliximab Drugs 0.000 description 4
- 229960005386 ipilimumab Drugs 0.000 description 4
- 229960004768 irinotecan Drugs 0.000 description 4
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 4
- 229960004961 mechlorethamine Drugs 0.000 description 4
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 4
- 229960001428 mercaptopurine Drugs 0.000 description 4
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 4
- 229960004857 mitomycin Drugs 0.000 description 4
- 229960003816 muromonab-cd3 Drugs 0.000 description 4
- 229960005027 natalizumab Drugs 0.000 description 4
- 229960002653 nilutamide Drugs 0.000 description 4
- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 4
- 229960002450 ofatumumab Drugs 0.000 description 4
- 229960000470 omalizumab Drugs 0.000 description 4
- 229960001756 oxaliplatin Drugs 0.000 description 4
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 4
- 229960000402 palivizumab Drugs 0.000 description 4
- 229960003171 plicamycin Drugs 0.000 description 4
- 108010048507 poliovirus receptor Proteins 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 229960003876 ranibizumab Drugs 0.000 description 4
- 208000016691 refractory malignant neoplasm Diseases 0.000 description 4
- 229960004641 rituximab Drugs 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 4
- 229960001278 teniposide Drugs 0.000 description 4
- 150000003505 terpenes Chemical class 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000001732 thrombotic effect Effects 0.000 description 4
- 229960003989 tocilizumab Drugs 0.000 description 4
- 229960000303 topotecan Drugs 0.000 description 4
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 4
- 229960005267 tositumomab Drugs 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 229960000575 trastuzumab Drugs 0.000 description 4
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 4
- 229960004824 triptorelin Drugs 0.000 description 4
- 229960000653 valrubicin Drugs 0.000 description 4
- ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 4
- 229960003048 vinblastine Drugs 0.000 description 4
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 4
- 229960004528 vincristine Drugs 0.000 description 4
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 4
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 4
- 229960004355 vindesine Drugs 0.000 description 4
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 4
- 229960002066 vinorelbine Drugs 0.000 description 4
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 3
- 206010047115 Vasculitis Diseases 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 206010025135 lupus erythematosus Diseases 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- UJZDIKVQFMCLBE-UHFFFAOYSA-N 1-(4-ethylphenyl)-3-(1h-indol-3-yl)urea Chemical compound C1=CC(CC)=CC=C1NC(=O)NC1=CNC2=CC=CC=C12 UJZDIKVQFMCLBE-UHFFFAOYSA-N 0.000 description 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 description 1
- 229940122113 STING antagonist Drugs 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962793623P | 2019-01-17 | 2019-01-17 | |
| US62/793,623 | 2019-01-17 | ||
| US201962861702P | 2019-06-14 | 2019-06-14 | |
| US62/861,702 | 2019-06-14 | ||
| PCT/US2020/013824 WO2020150439A1 (en) | 2019-01-17 | 2020-01-16 | Compounds and compositions for treating conditions associated with sting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022517797A JP2022517797A (ja) | 2022-03-10 |
| JP2022517797A5 JP2022517797A5 (https=) | 2023-01-20 |
| JPWO2020150439A5 true JPWO2020150439A5 (https=) | 2023-01-20 |
Family
ID=69593778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021541215A Pending JP2022517797A (ja) | 2019-01-17 | 2020-01-16 | Sting活性に関連する状態を治療するための化合物および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220388957A1 (https=) |
| EP (1) | EP3911314A1 (https=) |
| JP (1) | JP2022517797A (https=) |
| CN (1) | CN113874010A (https=) |
| MA (1) | MA54753A (https=) |
| WO (1) | WO2020150439A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112823036B (zh) | 2018-07-03 | 2024-11-08 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| CN112375027B (zh) * | 2020-12-07 | 2023-03-31 | 中国药科大学 | 吲哚磺酰胺类衍生物及其医药用途 |
| US20240060982A1 (en) | 2020-12-22 | 2024-02-22 | Ifm Due, Inc. | Methods of treating cancer |
| WO2022140397A1 (en) | 2020-12-22 | 2022-06-30 | Ifm Due, Inc. | Methods of treating cancer |
| EP4267128A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4267129A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| TW202235073A (zh) | 2021-01-08 | 2022-09-16 | 美商Ifm Due有限公司 | 用於治療與sting活性相關的病狀之化合物及組合物 |
| UY39892A (es) | 2021-08-10 | 2023-03-31 | Novartis Pharma Ag | Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING |
| KR20250052376A (ko) * | 2022-08-26 | 2025-04-18 | 에프. 호프만-라 로슈 아게 | 신규 중수소화 피리미딘-2-일 설폰아미드 유도체 |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0511993A1 (en) * | 1990-01-22 | 1992-11-11 | E.I. Du Pont De Nemours And Company | Herbicidal sulfonylureas |
| US6521658B1 (en) * | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| AU2002306604B2 (en) * | 2001-02-28 | 2007-09-13 | Onconova Therapeutics, Inc. | N-(Aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
| CA2473803A1 (en) * | 2002-02-01 | 2003-08-07 | Robert Greenhouse | Substituted indoles as alpha-1 agonists |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| DK2142516T3 (da) * | 2007-03-30 | 2013-04-15 | Sanofi Sa | Pyrimidinhydrazidforbindelser i ders egenskab af pgds-inhibitorer |
| WO2012075380A1 (en) | 2010-12-03 | 2012-06-07 | The Trustees Of The University Of Pennsylvania | Tip60 inhibitors |
| CN109394752A (zh) | 2013-10-21 | 2019-03-01 | 德雷克塞尔大学 | 治疗慢性乙型肝炎病毒感染的sting激动剂的用途 |
| FR3017867A1 (fr) * | 2014-02-21 | 2015-08-28 | Inventiva | Nouveaux composes de type phenylazetidine carboxylate ou carboxamide |
| AR106018A1 (es) * | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
| WO2017153952A1 (en) * | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
| US10858344B2 (en) * | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| TWI754702B (zh) * | 2016-12-28 | 2022-02-11 | 德商Ucb製藥有限公司 | (氮雜)吲哚-和苯並呋喃-3-磺醯胺類 |
| CN112823036B (zh) * | 2018-07-03 | 2024-11-08 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| US20210236466A1 (en) * | 2018-07-03 | 2021-08-05 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP3883651A1 (en) * | 2018-11-19 | 2021-09-29 | IFM Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| US20230092163A1 (en) * | 2019-06-14 | 2023-03-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| EP3983384B1 (en) * | 2019-06-17 | 2023-10-11 | UCB Pharma GmbH | N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis |
| CN114761804A (zh) * | 2019-06-21 | 2022-07-15 | 艾福姆德尤股份有限公司 | 治疗癌症的方法 |
-
2020
- 2020-01-16 MA MA054753A patent/MA54753A/fr unknown
- 2020-01-16 JP JP2021541215A patent/JP2022517797A/ja active Pending
- 2020-01-16 US US17/422,397 patent/US20220388957A1/en not_active Abandoned
- 2020-01-16 EP EP20705838.9A patent/EP3911314A1/en not_active Withdrawn
- 2020-01-16 CN CN202080021980.7A patent/CN113874010A/zh active Pending
- 2020-01-16 WO PCT/US2020/013824 patent/WO2020150439A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021529833A5 (https=) | ||
| JP2021529834A5 (https=) | ||
| JPWO2020010092A5 (https=) | ||
| JP6839761B2 (ja) | 抗PD−L1抗体との組み合わせのための抗Tim−3抗体 | |
| JP6839772B2 (ja) | 抗PD−1抗体との組み合わせのための抗Tim−3抗体 | |
| ES2967467T3 (es) | Combinación de una terapia celular y un compuesto inmunomodulador | |
| US11623961B2 (en) | Antibodies and chimeric antigen receptors specific for B-cell maturation antigen | |
| US10973915B2 (en) | Anti-PD-1 antibodies and uses thereof | |
| TWI751979B (zh) | 抗garp抗體 | |
| BR112021014833A2 (pt) | Anticorpos e receptores antigênicos quiméricos específicos para receptor órfão 1 de tipo tirosina quinase de receptor (ror1) | |
| CN111566484A (zh) | 细胞外囊泡蛋白及其在癌症诊断、预测对疗法的反应和治疗中的用途 | |
| JP2019513809A5 (https=) | ||
| JPWO2020106736A5 (https=) | ||
| BR112020000209A2 (pt) | moléculas de ligação que modulam uma atividade biológica expressa por uma célula | |
| KR20240090979A (ko) | Nkg2d, cd16, 및 trop2를 표적화하는 다중특이적 결합 단백질 | |
| JP2024023228A (ja) | Manaボディおよび使用方法 | |
| JPWO2021138419A5 (https=) | ||
| JPWO2020010155A5 (https=) | ||
| KR102380150B1 (ko) | Gitr 항체, 방법, 및 용도 | |
| WO2019030377A1 (en) | CD96 BINDING AGENTS AS IMMUNOMODULATORS | |
| BR112020000227A2 (pt) | anticorpos biespecíficos anti pd1-anti tim3 | |
| KR20180016443A (ko) | (z)-4-(5-((3-벤질-4-옥소-2-티옥소티아졸리딘-5-일리덴)메틸)푸란-2-일)벤조산의 고체형 | |
| JPWO2020150439A5 (https=) | ||
| US20240302349A1 (en) | Methods of assessing or monitoring a response to a cell therapy | |
| CN108699000B (zh) | 用于抑制趋化因子活性及/或癌细胞生长的小分子 |