JPWO2020138491A5 - - Google Patents
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- Publication number
- JPWO2020138491A5 JPWO2020138491A5 JP2020562548A JP2020562548A JPWO2020138491A5 JP WO2020138491 A5 JPWO2020138491 A5 JP WO2020138491A5 JP 2020562548 A JP2020562548 A JP 2020562548A JP 2020562548 A JP2020562548 A JP 2020562548A JP WO2020138491 A5 JPWO2020138491 A5 JP WO2020138491A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- preventive
- neurodevelopmental
- disorder
- cognitive impairment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 27
- 229940124597 therapeutic agent Drugs 0.000 claims 27
- 230000003449 preventive effect Effects 0.000 claims 19
- 208000010877 cognitive disease Diseases 0.000 claims 16
- 208000028698 Cognitive impairment Diseases 0.000 claims 13
- 230000003247 decreasing effect Effects 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 230000000069 prophylactic effect Effects 0.000 claims 8
- YQEZLKZALYSWHR-ZDUSSCGKSA-N (S)-ketamine Chemical compound C=1C=CC=C(Cl)C=1[C@@]1(NC)CCCCC1=O YQEZLKZALYSWHR-ZDUSSCGKSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 230000001771 impaired effect Effects 0.000 claims 4
- 229960003299 ketamine Drugs 0.000 claims 4
- 239000003826 tablet Substances 0.000 claims 4
- -1 troche Substances 0.000 claims 4
- 230000001755 vocal effect Effects 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000020358 Learning disease Diseases 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 208000029560 autism spectrum disease Diseases 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 201000003723 learning disability Diseases 0.000 claims 2
- 229940040145 liniment Drugs 0.000 claims 2
- 239000000865 liniment Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000014759 maintenance of location Effects 0.000 claims 2
- 230000008774 maternal effect Effects 0.000 claims 2
- 230000015654 memory Effects 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 239000000829 suppository Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 230000003936 working memory Effects 0.000 claims 2
- 208000007415 Anhedonia Diseases 0.000 claims 1
- 206010005885 Blunted affect Diseases 0.000 claims 1
- 206010021703 Indifference Diseases 0.000 claims 1
- 206010041243 Social avoidant behaviour Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018245688 | 2018-12-27 | ||
| JP2018245688 | 2018-12-27 | ||
| PCT/JP2019/051605 WO2020138491A1 (ja) | 2018-12-27 | 2019-12-27 | 神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020138491A1 JPWO2020138491A1 (https=) | 2020-07-02 |
| JPWO2020138491A5 true JPWO2020138491A5 (https=) | 2023-01-11 |
| JP7483630B2 JP7483630B2 (ja) | 2024-05-15 |
Family
ID=71127068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020562548A Active JP7483630B2 (ja) | 2018-12-27 | 2019-12-27 | 神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220110889A1 (https=) |
| EP (1) | EP3903775A4 (https=) |
| JP (1) | JP7483630B2 (https=) |
| WO (1) | WO2020138491A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE056378T2 (hu) | 2013-09-13 | 2022-02-28 | Univ Chiba Nat Univ Corp | R-Ketamin és sójának alkalmazása gyógyszerekként |
| US11980595B2 (en) | 2018-02-15 | 2024-05-14 | National University Corporation Chiba University | Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases |
| WO2019213551A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| IL312041A (en) | 2021-10-12 | 2024-06-01 | Perception Neuroscience Inc | R-ketamine salts and methods of using them |
| EP4493155A1 (en) | 2022-03-14 | 2025-01-22 | Perception Neuroscience, Inc. | Pharmaceutical formulations of r-ketamine |
| JP2023152104A (ja) * | 2022-04-01 | 2023-10-16 | 株式会社エル・エスコーポレーション | 認知機能の評価方法、及び、認知機能の評価装置 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619665C2 (de) | 1996-05-15 | 2001-03-08 | Goedecke Ag | Racemattrennung von Ketamin |
| US20120225949A1 (en) * | 2009-08-14 | 2012-09-06 | Demitri Papalos | Compositions and methods for treating bipolar disorder |
| US9737531B2 (en) * | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| HUE056378T2 (hu) * | 2013-09-13 | 2022-02-28 | Univ Chiba Nat Univ Corp | R-Ketamin és sójának alkalmazása gyógyszerekként |
| EP3094312B1 (en) * | 2014-01-14 | 2019-03-13 | Children's Hospital Medical Center | Compositions comprising ketamine for treating an autism spectrum disorder |
| EP3085366A1 (en) * | 2015-04-22 | 2016-10-26 | Institut du Cerveau et de la Moelle Epiniere-ICM | Nmda antagonists for the treatment of mental disorders with occurrence of aggressive and/or impulsive behavior |
| EP3442940A1 (en) * | 2016-04-11 | 2019-02-20 | Clexio Biosciences Ltd. | Deuterated ketamine derivatives |
| AU2018215056A1 (en) * | 2017-01-31 | 2019-08-08 | Charles E. Inturrisi | D-methadone and its derivatives for use in the treatment of disorders of the nervous system |
| US20200405663A1 (en) * | 2017-09-27 | 2020-12-31 | National University Corporation Chiba University | R-ketamine and derivative thereof as prophylactic or therapeutic agent for neurodegeneration disease or recognition functional disorder |
-
2019
- 2019-12-27 WO PCT/JP2019/051605 patent/WO2020138491A1/ja not_active Ceased
- 2019-12-27 US US17/417,557 patent/US20220110889A1/en active Pending
- 2019-12-27 EP EP19906114.4A patent/EP3903775A4/en active Pending
- 2019-12-27 JP JP2020562548A patent/JP7483630B2/ja active Active
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