JP7483630B2 - 神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 - Google Patents

神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 Download PDF

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JP7483630B2
JP7483630B2 JP2020562548A JP2020562548A JP7483630B2 JP 7483630 B2 JP7483630 B2 JP 7483630B2 JP 2020562548 A JP2020562548 A JP 2020562548A JP 2020562548 A JP2020562548 A JP 2020562548A JP 7483630 B2 JP7483630 B2 JP 7483630B2
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ketamine
neurodevelopmental disorder
therapeutic agent
cognitive dysfunction
acceptable salt
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JPWO2020138491A5 (https=
JPWO2020138491A1 (https=
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謙二 橋本
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Chiba University NUC
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Chiba University NUC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020562548A 2018-12-27 2019-12-27 神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体 Active JP7483630B2 (ja)

Applications Claiming Priority (3)

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JP2018245688 2018-12-27
JP2018245688 2018-12-27
PCT/JP2019/051605 WO2020138491A1 (ja) 2018-12-27 2019-12-27 神経発達障害の予防または治療剤としてのｒ－ケタミンおよびその誘導体

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JPWO2020138491A1 JPWO2020138491A1 (https=) 2020-07-02
JPWO2020138491A5 JPWO2020138491A5 (https=) 2023-01-11
JP7483630B2 true JP7483630B2 (ja) 2024-05-15

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US (1) US20220110889A1 (https=)
EP (1) EP3903775A4 (https=)
JP (1) JP7483630B2 (https=)
WO (1) WO2020138491A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE056378T2 (hu) 2013-09-13 2022-02-28 Univ Chiba Nat Univ Corp R-Ketamin és sójának alkalmazása gyógyszerekként
US11980595B2 (en) 2018-02-15 2024-05-14 National University Corporation Chiba University Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases
WO2019213551A1 (en) 2018-05-04 2019-11-07 Perception Neuroscience, Inc. Methods of treating substance abuse
IL312041A (en) 2021-10-12 2024-06-01 Perception Neuroscience Inc R-ketamine salts and methods of using them
EP4493155A1 (en) 2022-03-14 2025-01-22 Perception Neuroscience, Inc. Pharmaceutical formulations of r-ketamine
JP2023152104A (ja) * 2022-04-01 2023-10-16 株式会社エル・エスコーポレーション 認知機能の評価方法、及び、認知機能の評価装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150196501A1 (en) 2014-01-14 2015-07-16 Children's Hospital Medical Center Compositions and methods for treating an autism spectrum disorder

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19619665C2 (de) 1996-05-15 2001-03-08 Goedecke Ag Racemattrennung von Ketamin
US20120225949A1 (en) * 2009-08-14 2012-09-06 Demitri Papalos Compositions and methods for treating bipolar disorder
US9737531B2 (en) * 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
HUE056378T2 (hu) * 2013-09-13 2022-02-28 Univ Chiba Nat Univ Corp R-Ketamin és sójának alkalmazása gyógyszerekként
EP3085366A1 (en) * 2015-04-22 2016-10-26 Institut du Cerveau et de la Moelle Epiniere-ICM Nmda antagonists for the treatment of mental disorders with occurrence of aggressive and/or impulsive behavior
EP3442940A1 (en) * 2016-04-11 2019-02-20 Clexio Biosciences Ltd. Deuterated ketamine derivatives
AU2018215056A1 (en) * 2017-01-31 2019-08-08 Charles E. Inturrisi D-methadone and its derivatives for use in the treatment of disorders of the nervous system
US20200405663A1 (en) * 2017-09-27 2020-12-31 National University Corporation Chiba University R-ketamine and derivative thereof as prophylactic or therapeutic agent for neurodegeneration disease or recognition functional disorder

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150196501A1 (en) 2014-01-14 2015-07-16 Children's Hospital Medical Center Compositions and methods for treating an autism spectrum disorder

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JHONSON K. M. et al.，Phencyclidine: it ain’t excitin’, but it sure is toxic，13th International Congress on Amino Acids, peptides and proteins，2013年08月14日，Vol.45，pp.588-589
MOHAMMADI A. et al.，Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and susceptibility to Schizophren，Curr. Gene Ther.，2018年05月，Vol.18，pp.45-63
YANG C. et al.，R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects，Transl. Psychiatry，2015年09月01日，Vol.5，Article Number:e632, pp.1-11，doi: 10.1038/tp.2015.136

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WO2020138491A1 (ja) 2020-07-02
EP3903775A1 (en) 2021-11-03
EP3903775A4 (en) 2022-10-12
US20220110889A1 (en) 2022-04-14
JPWO2020138491A1 (https=) 2020-07-02

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