JPWO2020138487A5 - - Google Patents
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- JPWO2020138487A5 JPWO2020138487A5 JP2020562545A JP2020562545A JPWO2020138487A5 JP WO2020138487 A5 JPWO2020138487 A5 JP WO2020138487A5 JP 2020562545 A JP2020562545 A JP 2020562545A JP 2020562545 A JP2020562545 A JP 2020562545A JP WO2020138487 A5 JPWO2020138487 A5 JP WO2020138487A5
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- amino acid
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- bispecific antibody
- acid sequence
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- 210000004027 cell Anatomy 0.000 claims 5
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- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 4
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024096802A JP2024119984A (ja) | 2018-12-28 | 2024-06-14 | ＴｆＲに結合するバイスペシフィック抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018248334 | 2018-12-28 | ||
| JP2018248334 | 2018-12-28 | ||
| PCT/JP2019/051594 WO2020138487A1 (ja) | 2018-12-28 | 2019-12-27 | ＴｆＲに結合するバイスペシフィック抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024096802A Division JP2024119984A (ja) | 2018-12-28 | 2024-06-14 | ＴｆＲに結合するバイスペシフィック抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020138487A1 JPWO2020138487A1 (ja) | 2021-11-11 |
| JPWO2020138487A5 true JPWO2020138487A5 (https=) | 2023-08-28 |
| JP7506607B2 JP7506607B2 (ja) | 2024-06-26 |
Family
ID=71125764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020562545A Active JP7506607B2 (ja) | 2018-12-28 | 2019-12-27 | ＴｆＲに結合するバイスペシフィック抗体 |
| JP2024096802A Pending JP2024119984A (ja) | 2018-12-28 | 2024-06-14 | ＴｆＲに結合するバイスペシフィック抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024096802A Pending JP2024119984A (ja) | 2018-12-28 | 2024-06-14 | ＴｆＲに結合するバイスペシフィック抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12258413B2 (https=) |
| EP (1) | EP3903816A4 (https=) |
| JP (2) | JP7506607B2 (https=) |
| KR (1) | KR20210108961A (https=) |
| CN (1) | CN113226371B (https=) |
| AU (1) | AU2019413278B2 (https=) |
| BR (1) | BR112021012569A2 (https=) |
| CA (1) | CA3125316A1 (https=) |
| MX (1) | MX2021007797A (https=) |
| MY (1) | MY210422A (https=) |
| SG (1) | SG11202106990PA (https=) |
| TW (2) | TWI907249B (https=) |
| WO (1) | WO2020138487A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113563473A (zh) * | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
| WO2023083381A1 (zh) | 2021-11-15 | 2023-05-19 | 成都百利多特生物药业有限责任公司 | 双特异性抗体-喜树碱类药物偶联物及其医药用途 |
| KR20250162888A (ko) * | 2023-03-24 | 2025-11-19 | 바이오악틱 에이비 | 인간 트랜스페린 수용체 htfr1의 프로테아제-유사 도메인에 결합하는 이중특이적 항체 |
| AU2024299328A1 (en) | 2023-07-21 | 2026-01-22 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
| TW202517685A (zh) * | 2023-10-26 | 2025-05-01 | 美商百健Ｍａ公司 | 抗運鐵蛋白受體抗體及其用途 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US570561A (en) | 1896-11-03 | S peters co | ||
| US2808035A (en) | 1953-04-23 | 1957-10-01 | Riley Stoker Corp | Burning wet materials |
| JPS5623587A (en) | 1979-08-03 | 1981-03-05 | Mitsuwa Seiki Co Ltd | Vane type compressor |
| JPS58110600A (ja) | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
| WO1985003934A1 (fr) | 1984-03-06 | 1985-09-12 | Takeda Chemical Industries, Ltd. | Proteine modifiee chimiquement et son procede de preparation |
| JPS60221091A (ja) | 1983-12-21 | 1985-11-05 | Kyowa Hakko Kogyo Co Ltd | 新規プロモ−タ− |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| JP2564268B2 (ja) | 1985-08-28 | 1996-12-18 | 協和醗酵工業株式会社 | 融合抗原ポリペプチド |
| ZA872705B (en) | 1986-04-22 | 1987-10-05 | Immunex Corporation | Human g-csf protein expression |
| JP2958019B2 (ja) | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
| JP2928287B2 (ja) | 1988-09-29 | 1999-08-03 | 協和醗酵工業株式会社 | 新規ポリペプチド |
| JPH02257891A (ja) | 1989-03-31 | 1990-10-18 | Kyowa Hakko Kogyo Co Ltd | 組換え動物細胞による蛋白質の製造 |
| JPH0322979A (ja) | 1989-06-19 | 1991-01-31 | Kyowa Hakko Kogyo Co Ltd | 新規プラスミノーゲン活性化因子 |
| JP3131322B2 (ja) | 1991-12-17 | 2001-01-31 | 協和醗酵工業株式会社 | 新規α２→３シアリルトランスフェラーゼ |
| US6042828A (en) | 1992-09-07 | 2000-03-28 | Kyowa Hakko Kogyo Co., Ltd. | Humanized antibodies to ganglioside GM2 |
| JP3756946B2 (ja) | 1993-03-29 | 2006-03-22 | 協和醗酵工業株式会社 | α１，３−フコシルトランスフェラーゼ |
| US5705614A (en) | 1993-04-09 | 1998-01-06 | Chiron Corporation | Methods of producing antigen forks |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| ES2233974T3 (es) | 1995-09-11 | 2005-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Anticuerpo contra la cadena alfa del receptor de la interleucina 5 humana. |
| US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| ATE299938T1 (de) | 1997-05-02 | 2005-08-15 | Genentech Inc | Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PL209392B1 (pl) | 1999-01-15 | 2011-08-31 | Genentech Inc | Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała |
| CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
| JP2003531588A (ja) | 2000-04-11 | 2003-10-28 | ジェネンテック・インコーポレーテッド | 多価抗体とその用途 |
| DK2990420T3 (en) * | 2000-05-26 | 2017-04-03 | Immunex Corp | USE OF INTERLEUKIN-4 RECEPTOR ANTIBODIES AND COMPOSITIONS THEREOF |
| KR100919593B1 (ko) | 2000-06-29 | 2009-09-29 | 아보트 러보러터리즈 | 이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물 |
| CA2953239A1 (en) | 2000-10-06 | 2002-04-18 | Kyowa Hakko Kirin Co., Ltd. | Antibody composition-producing cell |
| US7262278B2 (en) | 2001-10-15 | 2007-08-28 | Kirin Beer Kabushiki Kaisha | Anti-HLA-DR antibody |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| JPWO2005035586A1 (ja) | 2003-10-08 | 2007-11-22 | 協和醗酵工業株式会社 | 融合蛋白質組成物 |
| EP1810979B1 (en) | 2004-09-22 | 2012-06-20 | Kyowa Hakko Kirin Co., Ltd. | STABILIZED HUMAN IgG4 ANTIBODIES |
| US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JP5522405B2 (ja) | 2008-04-25 | 2014-06-18 | 協和発酵キリン株式会社 | 安定な多価抗体 |
| CA2742969A1 (en) * | 2008-11-07 | 2010-05-14 | Fabrus Llc | Anti-dll4 antibodies and uses thereof |
| KR20120024763A (ko) * | 2009-05-15 | 2012-03-14 | 추가이 세이야쿠 가부시키가이샤 | 항ａｘｌ 항체 |
| ES2697535T3 (es) | 2009-06-11 | 2019-01-24 | Inter Univ Research Institute Corporation Research Organization Of Information And Systems | Procedimiento para la producción de proteína |
| WO2011116387A1 (en) | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
| CA2818173C (en) | 2010-11-30 | 2022-05-03 | Genentech, Inc. | Low affinity blood brain barrier receptor antibodies and uses therefor |
| EP2699603B1 (en) | 2011-04-19 | 2016-03-02 | The United States of America As Represented by the Secretary Department of Health and Human Services | Human monoclonal antibodies specific for glypican-3 and use thereof |
| CA2835603A1 (en) | 2011-05-09 | 2012-11-15 | Perseus Proteomics Inc. | Antibody capable of specifically recognizing transferrin receptor |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| RS60499B1 (sr) | 2011-12-20 | 2020-08-31 | Medimmune Llc | Modifikovani polipeptidi za bispecifične skelete antitela |
| EP2825553B1 (en) | 2012-03-14 | 2018-07-25 | Regeneron Pharmaceuticals, Inc. | Multispecific antigen-binding molecules and uses thereof |
| WO2013177062A2 (en) | 2012-05-21 | 2013-11-28 | Genentech, Inc. | Methods for improving safety of blood-brain barrier transport |
| EP3594240B1 (en) | 2013-05-20 | 2023-12-06 | F. Hoffmann-La Roche AG | Anti-transferrin receptor antibodies and methods of use |
| US9388243B2 (en) | 2013-05-29 | 2016-07-12 | Samsung Electronics Co., Ltd. | Method of target membrane protein depletion |
| DK3078744T3 (da) * | 2013-12-04 | 2020-09-28 | Chugai Pharmaceutical Co Ltd | Antigen-bindende molekyler, antigen-bindingsaktiviteten af hvilke varierer i henhold til koncentrationen af forbindelser, og biblioteker af molekylerne |
| SG11201608253XA (en) | 2014-04-04 | 2016-10-28 | Kyowa Hakko Kirin Co Ltd | Anti-death receptor 3 (dr3) antagonistic antibodies with reduced agonistic activity |
| WO2016081640A1 (en) * | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
| US10508151B2 (en) * | 2014-11-19 | 2019-12-17 | Genentech, Inc. | Anti-transferrin receptor antibodies and methods of use |
| JPWO2016111344A1 (ja) * | 2015-01-08 | 2017-10-26 | 協和発酵キリン株式会社 | Ｔｒａｉｌｒ２とｐｓｍａに結合するバイスペシフィック抗体 |
| HUE057952T2 (hu) * | 2015-06-24 | 2022-06-28 | Hoffmann La Roche | Anti-transzferrin receptor antitestek testreszabott affinitással |
| KR20180030030A (ko) * | 2015-07-15 | 2018-03-21 | 교와 핫꼬 기린 가부시키가이샤 | 인간 crth2에 특이적으로 결합하는 항체 |
| CA3023667A1 (en) * | 2016-05-09 | 2017-11-16 | Annexon, Inc. | Compositions and methods for treating spinal muscular atrophy |
| KR102156626B1 (ko) | 2018-07-16 | 2020-09-17 | 주식회사 셀바스에이아이 | 운동 처방 정보를 제공하는 서버 및 컴퓨터 프로그램 |
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2019
- 2019-12-27 WO PCT/JP2019/051594 patent/WO2020138487A1/ja not_active Ceased
- 2019-12-27 CA CA3125316A patent/CA3125316A1/en active Pending
- 2019-12-27 MY MYPI2021003612A patent/MY210422A/en unknown
- 2019-12-27 CN CN201980086662.6A patent/CN113226371B/zh active Active
- 2019-12-27 US US17/418,447 patent/US12258413B2/en active Active
- 2019-12-27 BR BR112021012569-8A patent/BR112021012569A2/pt unknown
- 2019-12-27 JP JP2020562545A patent/JP7506607B2/ja active Active
- 2019-12-27 SG SG11202106990PA patent/SG11202106990PA/en unknown
- 2019-12-27 MX MX2021007797A patent/MX2021007797A/es unknown
- 2019-12-27 KR KR1020217019406A patent/KR20210108961A/ko active Pending
- 2019-12-27 EP EP19901837.5A patent/EP3903816A4/en active Pending
- 2019-12-27 AU AU2019413278A patent/AU2019413278B2/en active Active
- 2019-12-27 TW TW114101537A patent/TWI907249B/zh active
- 2019-12-27 TW TW108148133A patent/TWI873112B/zh active
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2024
- 2024-06-14 JP JP2024096802A patent/JP2024119984A/ja active Pending
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2025
- 2025-02-19 US US19/057,265 patent/US20250250352A1/en active Pending
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