JPWO2020132232A5 - - Google Patents

Info

Publication number

JPWO2020132232A5

JPWO2020132232A5 JP2021536253A JP2021536253A JPWO2020132232A5 JP WO2020132232 A5 JPWO2020132232 A5 JP WO2020132232A5 JP 2021536253 A JP2021536253 A JP 2021536253A JP 2021536253 A JP2021536253 A JP 2021536253A JP WO2020132232 A5 JPWO2020132232 A5 JP WO2020132232A5

Authority

JP

Japan

Prior art keywords

antibody

cdr2

cdr3

cdr1

linker

Prior art date

2022-12-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 125000005647 linker group Chemical group 0.000 claims 13
• 125000000539 amino acid group Chemical group 0.000 claims 7
• 239000000611 antibody drug conjugate Substances 0.000 claims 7
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 7
• 210000004027 cell Anatomy 0.000 claims 7
• 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 claims 5
• 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 101100458666 Homo sapiens MCAM gene Proteins 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• 239000013598 vector Substances 0.000 claims 4
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 229940127089 cytotoxic agent Drugs 0.000 claims 2
• 239000002254 cytotoxic agent Substances 0.000 claims 2
• 231100000599 cytotoxic agent Toxicity 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 1
• 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 1
• HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
• NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical group C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 1
• 108010024636 Glutathione Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 241000288906 Primates Species 0.000 claims 1
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 1
• NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
• 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 229960002173 citrulline Drugs 0.000 claims 1
• 210000004748 cultured cell Anatomy 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical group C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 229960003180 glutathione Drugs 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• PGLTVOMIXTUURA-UHFFFAOYSA-N iodoacetamide Chemical group NC(=O)CI PGLTVOMIXTUURA-UHFFFAOYSA-N 0.000 claims 1
• 238000002372 labelling Methods 0.000 claims 1
• 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate group Chemical group C(C(=C)C)(=O)[O-] CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 108010093470 monomethyl auristatin E Proteins 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• 150000003568 thioethers Chemical class 0.000 claims 1
• 150000003852 triazoles Chemical class 0.000 claims 1