JPWO2020132218A5 - - Google Patents

Info

Publication number

JPWO2020132218A5

JPWO2020132218A5 JP2021535081A JP2021535081A JPWO2020132218A5 JP WO2020132218 A5 JPWO2020132218 A5 JP WO2020132218A5 JP 2021535081 A JP2021535081 A JP 2021535081A JP 2021535081 A JP2021535081 A JP 2021535081A JP WO2020132218 A5 JPWO2020132218 A5 JP WO2020132218A5

Authority

JP

Japan

Prior art keywords

parasiticidal

formulation according

parasiticidal formulation

group

benzyl alcohol

Prior art date

2022-12-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 31
• 238000009472 formulation Methods 0.000 claims 29
• WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 27
• 230000000590 parasiticidal Effects 0.000 claims 26
• 150000002596 lactones Chemical class 0.000 claims 14
• 239000002904 solvent Substances 0.000 claims 14
• 229960004217 benzyl alcohol Drugs 0.000 claims 9
• 235000019445 benzyl alcohol Nutrition 0.000 claims 9
• YZBLFMPOMVTDJY-RWJZGKSFSA-N Moxidectin Chemical compound O1[C@H](C(\C)=C\C(C)C)[C@@H](C)C(=N/OC)\C[C@@]11O[C@H](C\C=C(C)\C[C@@H](C)C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YZBLFMPOMVTDJY-RWJZGKSFSA-N 0.000 claims 6
• 229960004816 Moxidectin Drugs 0.000 claims 6
• RUOJZAUFBMNUDX-UHFFFAOYSA-N Propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 6
• 230000000240 adjuvant Effects 0.000 claims 5
• 239000002671 adjuvant Substances 0.000 claims 5
• 239000003963 antioxidant agent Substances 0.000 claims 5
• 229940095259 Butylated Hydroxytoluene Drugs 0.000 claims 4
• 239000004322 Butylated hydroxytoluene Substances 0.000 claims 4
• NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 4
• 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 4
• 239000006184 cosolvent Substances 0.000 claims 4
• 241001465754 Metazoa Species 0.000 claims 3
• 230000003078 antioxidant Effects 0.000 claims 3
• 150000005676 cyclic carbonates Chemical class 0.000 claims 3
• 150000004040 pyrrolidinones Chemical class 0.000 claims 3
• QLFZZSKTJWDQOS-YDBLARSUSA-N Doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 claims 2
• WPNHOHPRXXCPRA-TVXIRPTOSA-N Eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 claims 2
• 229960002245 Selamectin Drugs 0.000 claims 2
• 230000000111 anti-oxidant Effects 0.000 claims 2
• RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims 2
• ZFUKERYTFURFGA-PVVXTEPVSA-N avermectin B1b Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C ZFUKERYTFURFGA-PVVXTEPVSA-N 0.000 claims 2
• 239000003086 colorant Substances 0.000 claims 2
• 229960003997 doramectin Drugs 0.000 claims 2
• 244000079386 endoparasites Species 0.000 claims 2
• 229960002346 eprinomectin Drugs 0.000 claims 2
• 239000004611 light stabiliser Substances 0.000 claims 2
• 230000002335 preservative Effects 0.000 claims 2
• 239000003755 preservative agent Substances 0.000 claims 2
• AFJYYKSVHJGXSN-XHKIUTQPSA-N selamectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1C(/C)=C/C[C@@H](O[C@]2(O[C@@H]([C@@H](C)CC2)C2CCCCC2)C2)C[C@@H]2OC(=O)[C@@H]([C@]23O)C=C(C)C(=N/O)/[C@H]3OC\C2=C/C=C/[C@@H]1C AFJYYKSVHJGXSN-XHKIUTQPSA-N 0.000 claims 2
• 239000004544 spot-on Substances 0.000 claims 2
• -1 tackifiers Substances 0.000 claims 2
• 239000002562 thickening agent Substances 0.000 claims 2
• 241000282326 Felis catus Species 0.000 claims 1
• 210000003491 Skin Anatomy 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 244000144972 livestock Species 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1