JPWO2020104649A5 - - Google Patents
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- JPWO2020104649A5 JPWO2020104649A5 JP2021528936A JP2021528936A JPWO2020104649A5 JP WO2020104649 A5 JPWO2020104649 A5 JP WO2020104649A5 JP 2021528936 A JP2021528936 A JP 2021528936A JP 2021528936 A JP2021528936 A JP 2021528936A JP WO2020104649 A5 JPWO2020104649 A5 JP WO2020104649A5
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- JP
- Japan
- Prior art keywords
- dsrna
- seq
- nos
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- sense
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18306562 | 2018-11-23 | ||
| EP18306562.2 | 2018-11-23 | ||
| PCT/EP2019/082216 WO2020104649A2 (en) | 2018-11-23 | 2019-11-22 | Novel rna compositions and methods for inhibiting angptl8 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022513111A JP2022513111A (ja) | 2022-02-07 |
| JP2022513111A5 JP2022513111A5 (https=) | 2022-11-29 |
| JPWO2020104649A5 true JPWO2020104649A5 (https=) | 2022-11-29 |
| JP7707065B2 JP7707065B2 (ja) | 2025-07-14 |
Family
ID=64564803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021528936A Active JP7707065B2 (ja) | 2018-11-23 | 2019-11-22 | Ａｎｇｐｔｌ８を阻害するための新規のｒｎａ組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US12416004B2 (https=) |
| EP (1) | EP3884051A2 (https=) |
| JP (1) | JP7707065B2 (https=) |
| CN (1) | CN113166760A (https=) |
| WO (1) | WO2020104649A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3884051A2 (en) | 2018-11-23 | 2021-09-29 | Sanofi | Novel rna compositions and methods for inhibiting angptl8 |
| JP7667775B2 (ja) * | 2019-09-05 | 2025-04-23 | サノフイ | ヌクレオチド類似体を含有するオリゴヌクレオチド |
| CA3224145A1 (en) | 2021-06-24 | 2022-12-29 | Melissa Ann Bellinger | Novel rna therapeutics and uses thereof |
| WO2024138111A1 (en) | 2022-12-23 | 2024-06-27 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| CN118421622A (zh) * | 2023-02-01 | 2024-08-02 | 北京福元医药股份有限公司 | 抑制血管生成素样蛋白8基因表达的siRNA、其缀合物和药物组合物及用途 |
| WO2024227059A2 (en) * | 2023-04-27 | 2024-10-31 | Aligos Therapeutics, Inc. | Short interfering nucleic acid (sina) molecules targeting angptl 3 and angptl 8 and methods of using the same |
| WO2025264952A2 (en) | 2024-06-21 | 2025-12-26 | Eli Lilly And Company | Novel rna therapeutics and uses thereof |
| CN119367545B (zh) * | 2025-01-02 | 2025-04-08 | 山东第一医科大学(山东省医学科学院) | 靶向干预ANGPTL8 mRNA在制备治疗高同型半胱氨酸血症药物中的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5665710A (en) | 1990-04-30 | 1997-09-09 | Georgetown University | Method of making liposomal oligodeoxynucleotide compositions |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| WO1994002595A1 (en) | 1992-07-17 | 1994-02-03 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of animal diseases |
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US6054299A (en) | 1994-04-29 | 2000-04-25 | Conrad; Charles A. | Stem-loop cloning vector and method |
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| ATE285477T1 (de) | 1995-06-07 | 2005-01-15 | Inex Pharmaceutical Corp | Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| WO2000003683A2 (en) | 1998-07-20 | 2000-01-27 | Inex Pharmaceuticals Corporation | Liposomal encapsulated nucleic acid-complexes |
| MXPA01003642A (es) | 1998-10-09 | 2003-07-21 | Ingene Inc | Sintesis enzimatica de adnss. |
| BR9914773A (pt) | 1998-10-09 | 2002-02-05 | Ingene Inc | Conjunto de elementos genéricos, método para a produção de dna de cordão único, transcrição de mrna, construção de ácido nucléico, transcrição de ssdna, vetor, sistema vetor, célula hospedeira, conjunto para a produção de uma sequência de ácido nucléico de cordão único, método para a produção in vivo ou in vitro de uma sequência de ácido nucléico de cordão único, transcrição de cdna de cordão único, ácido nucléico inibidor, molécula heteroduplex, e composição farmacêutica |
| US8137695B2 (en) * | 2006-08-18 | 2012-03-20 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| EP2305812A3 (en) | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| ES2641272T3 (es) * | 2006-04-28 | 2017-11-08 | Children's Hospital Medical Center | Composiciones que comprenden proteínas o polipéptidos fusogénicos derivados de la prosaposina para aplicación en sistemas de suministro de fármacos transmembrana |
| ES2428009T3 (es) * | 2007-07-05 | 2013-11-05 | Novartis Ag | ARNds para tratar infecciones virales |
| WO2009082607A2 (en) | 2007-12-04 | 2009-07-02 | Alnylam Pharmaceuticals, Inc. | Targeting lipids |
| US20100249214A1 (en) | 2009-02-11 | 2010-09-30 | Dicerna Pharmaceuticals | Multiplex dicer substrate rna interference molecules having joining sequences |
| AU2013299717B2 (en) * | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| DK2991656T3 (da) | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| KR20180132843A (ko) * | 2016-04-08 | 2018-12-12 | 리제너론 파아마슈티컬스, 인크. | Angptl8 억제제 및 angptl3 억제제로 고지혈증을 치료하는 방법 |
| EP3762395A1 (en) | 2018-03-07 | 2021-01-13 | Sanofi | Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same |
| EP3884051A2 (en) | 2018-11-23 | 2021-09-29 | Sanofi | Novel rna compositions and methods for inhibiting angptl8 |
| US20220290156A1 (en) | 2019-08-27 | 2022-09-15 | Sanofi | Compositions and methods for inhibiting pcsk9 |
| JP7667775B2 (ja) | 2019-09-05 | 2025-04-23 | サノフイ | ヌクレオチド類似体を含有するオリゴヌクレオチド |
| JP2023546103A (ja) | 2020-10-16 | 2023-11-01 | サノフイ | Ａｎｇｐｔｌ３を阻害するための新規のｒｎａ組成物および方法 |
| US20240035029A1 (en) | 2020-10-16 | 2024-02-01 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
| EP4232455A2 (en) | 2020-10-20 | 2023-08-30 | Sanofi | Novel ligands for asialoglycoprotein receptor |
-
2019
- 2019-11-22 EP EP19805337.3A patent/EP3884051A2/en active Pending
- 2019-11-22 CN CN201980077074.6A patent/CN113166760A/zh active Pending
- 2019-11-22 US US17/296,530 patent/US12416004B2/en active Active
- 2019-11-22 WO PCT/EP2019/082216 patent/WO2020104649A2/en not_active Ceased
- 2019-11-22 JP JP2021528936A patent/JP7707065B2/ja active Active
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