CN113166760A - 用于抑制angptl8的新型rna组合物和方法 - Google Patents

用于抑制angptl8的新型rna组合物和方法 Download PDF

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Publication number
CN113166760A
CN113166760A CN201980077074.6A CN201980077074A CN113166760A CN 113166760 A CN113166760 A CN 113166760A CN 201980077074 A CN201980077074 A CN 201980077074A CN 113166760 A CN113166760 A CN 113166760A
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dsrna
artificial sequence
sources
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rna
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B·布鲁纳
M·赫尔姆斯
A·霍夫迈斯特
K·杰恩-霍夫曼
C·梅斯-魏德曼
S·谢德勒
P·里弗
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Sanofi SA
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Sanofi SA
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2320/30—Special therapeutic applications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980077074.6A 2018-11-23 2019-11-22 用于抑制angptl8的新型rna组合物和方法 Pending CN113166760A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18306562 2018-11-23
EP18306562.2 2018-11-23
PCT/EP2019/082216 WO2020104649A2 (en) 2018-11-23 2019-11-22 Novel rna compositions and methods for inhibiting angptl8

Publications (1)

Publication Number Publication Date
CN113166760A true CN113166760A (zh) 2021-07-23

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CN201980077074.6A Pending CN113166760A (zh) 2018-11-23 2019-11-22 用于抑制angptl8的新型rna组合物和方法

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US (1) US12416004B2 (https=)
EP (1) EP3884051A2 (https=)
JP (1) JP7707065B2 (https=)
CN (1) CN113166760A (https=)
WO (1) WO2020104649A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119367545A (zh) * 2025-01-02 2025-01-28 山东第一医科大学(山东省医学科学院) 靶向干预ANGPTL8 mRNA在制备治疗高同型半胱氨酸血症药物中的应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3884051A2 (en) 2018-11-23 2021-09-29 Sanofi Novel rna compositions and methods for inhibiting angptl8
JP7667775B2 (ja) * 2019-09-05 2025-04-23 サノフイ ヌクレオチド類似体を含有するオリゴヌクレオチド
CA3224145A1 (en) 2021-06-24 2022-12-29 Melissa Ann Bellinger Novel rna therapeutics and uses thereof
WO2024138111A1 (en) 2022-12-23 2024-06-27 Eli Lilly And Company Novel rna therapeutics and uses thereof
CN118421622A (zh) * 2023-02-01 2024-08-02 北京福元医药股份有限公司 抑制血管生成素样蛋白8基因表达的siRNA、其缀合物和药物组合物及用途
WO2024227059A2 (en) * 2023-04-27 2024-10-31 Aligos Therapeutics, Inc. Short interfering nucleic acid (sina) molecules targeting angptl 3 and angptl 8 and methods of using the same
WO2025264952A2 (en) 2024-06-21 2025-12-26 Eli Lilly And Company Novel rna therapeutics and uses thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119367545A (zh) * 2025-01-02 2025-01-28 山东第一医科大学(山东省医学科学院) 靶向干预ANGPTL8 mRNA在制备治疗高同型半胱氨酸血症药物中的应用

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JP7707065B2 (ja) 2025-07-14
EP3884051A2 (en) 2021-09-29
US20220025367A1 (en) 2022-01-27
WO2020104649A2 (en) 2020-05-28
WO2020104649A3 (en) 2020-07-02
US12416004B2 (en) 2025-09-16
JP2022513111A (ja) 2022-02-07

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